The prevalence of apoptotic keratinocytes in equine epidermis: a retrospective light-microscopic study of skin-biopsy specimens from 253 horses with normal skin or inflammatory dermatoses.
Abstract: A retrospective study was performed to assess the prevalence of apoptotic epidermal keratinocytes in biopsy specimens from 226 horses with inflammatory dermatoses and from 27 normal specimens. One or more apoptotic keratinocytes were found in specimens from 28 of 226 (12%) horses with various dermatoses, and in one of 27 (4%) specimens from normal horses. The prevalence (proportion of cases with apoptotic epidermal keratinocytes) of apoptotic keratinocytes in the group composed of discoid lupus erythematosus, erythema multiforme, photodermatitis, and systemic lupus erythematosus was significantly greater (52% prevalence in these cases) than that in a grouping of all other dermatoses (prevalence 8%). There was no correlation between the number of apoptotic keratinocytes and the extent of epidermal hyperplasia or hyperkeratosis.
Publication Date: 2004-12-22 PubMed ID: 15610480DOI: 10.1111/j.1439-0442.2004.00665.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research is an examination of the prevalence of apoptotic (degenerative) epidermal keratinocytes (skin cells) in horse skin tissue, both normal and suffering from various skin inflammatory conditions. The study finds that skin samples from inflamed skin were more likely to show signs of cell degeneration than those from normal skin, particularly for certain skin conditions.
Study Subjects and Methods
- The study was a retrospective analysis, meaning that it used already available data, in this case, skin biopsy specimens from a total of 253 horses.
- Of these, 226 specimens were from horses diagnosed with various inflammatory skin conditions, known as dermatoses, while 27 were from horses with normal skin.
Findings
- Out of the 226 horses with dermatoses, 28 (or 12%) had skin samples showing one or more apoptotic keratinocytes.
- Just one (or 4%) of the 27 horses with normal skin also showed these apoptotic keratinocytes.
Apoptotic Keratinocytes and Specific Conditions
- The research went further to analyze the prevalence of apoptotic keratinocytes in connection with specific dermatoses.
- Certain conditions – discoid lupus erythematosus, erythema multiforme, photodermatitis, and systemic lupus erythematosus – showed a significantly higher prevalence (52%) than all other dermatoses put together (8%).
Absence of Correlation
- The study did not find any correlation between the number of apoptotic keratinocytes and the extent of two particular skin conditions – epidermal hyperplasia or hyperkeratosis.
Implications
- This research suggests that apoptotic keratinocytes might be more prevalently found in horses suffering from inflammatory skin conditions compared to those with normal skin.
- The higher incidence in certain skin conditions compared to others could prove useful in diagnosing and potentially treating these conditions.
Cite This Article
APA
Macleod KD, Scott DW, Erb HN.
(2004).
The prevalence of apoptotic keratinocytes in equine epidermis: a retrospective light-microscopic study of skin-biopsy specimens from 253 horses with normal skin or inflammatory dermatoses.
J Vet Med A Physiol Pathol Clin Med, 51(9-10), 400-404.
https://doi.org/10.1111/j.1439-0442.2004.00665.x Publication
Researcher Affiliations
- Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
MeSH Terms
- Animals
- Apoptosis
- Biopsy / veterinary
- Case-Control Studies
- Epidermal Cells
- Epidermis / pathology
- Horse Diseases / pathology
- Horses
- Keratinocytes / pathology
- Prevalence
- Retrospective Studies
- Skin / cytology
- Skin / pathology
- Skin Diseases / pathology
- Skin Diseases / veterinary
Citations
This article has been cited 2 times.- Griffin JS, Scott DW, Erb HN. Prevalence of apoptotic epidermal keratinocytes in eosinophilic dermatoses of the cat: a retrospective light-microscopic study of 145 skin-biopsy specimens. J Feline Med Surg 2010 Feb;12(2):86-90.
- Vogel JW, Scott DW, Erb HN. Frequency of apoptotic keratinocytes in the feline epidermis: a retrospective light-microscopic study of skin-biopsy specimens from 327 cats with normal skin or inflammatory dermatoses. J Feline Med Surg 2009 Dec;11(12):963-9.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
