THE PRODUCTION AND TITRATION OF POTENT HORSE ANTIPNEUMOTOXIN.
Abstract: 1. The serum of horses immunized with increasing doses of certain anaerobically produced autolysates of pneumococci contain potent neutralizing antibodies for the pneumotoxin. 2. The method for the in vitro titration of these horse antipneumotoxic serums is given.
Publication Date: 1929-06-30 PubMed ID: 19869600PubMed Central: PMC2131611DOI: 10.1084/jem.50.1.103Google Scholar: Lookup
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- Journal Article
Summary
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This research focuses on the production and measurement of strong anti-toxin against pneumococcus from horses that have been immunized with certain autolysates of pneumococci, and the methodology for this process.
Production of Horse Antipneumotoxin
- Firstly, the research revolves around the production of what is referred to as horse antipneumotoxin. This is a neutralizing antibody created in the serum of horses.
- To stimulate the production of this antipneumotoxin, horses are immunized with increasing doses of certain autolysates of pneumococci. Autolysates are essentially self-digested cells, in this case, pneumococci – a type of bacteria that can cause illnesses like pneumonia, meningitis, and sepsis.
- The immunization of horses using these autolysates triggers their bodies to create a powerful response in the form of neutralizing antibodies. These antibodies are basically proteins produced by the immune system that can identify, neutralize, and help remove foreign threats like viruses, bacteria, and other harmful microorganisms. In this scenario, these antibodies are specifically designed to combat pneumococcus hence referred to as antipneumotoxin.
Titration of Horse Antipneumotoxin
- Next, the research explains a method for titrating the horse antipneumotoxic serums produced. In context, titration is a process used in laboratories to determine the concentration of a substance in a solution. Here, the ‘substance’ is the horse antipneumotoxin in the serum.
- This process would allow researchers to accurately measure the concentration of antipneumotoxin produced by the horses. Understanding this concentration is crucial for subsequent steps such as calculating the effective therapeutic dosage.
Importance of the Research
- The findings from this research could provide valuable insights into the potential use of horse-derived antipneumotoxin as a possible treatment for diseases caused by pneumococci, such as pneumonia and meningitis. The methodology used in this research could also guide future studies related to antibody production and titration.
Cite This Article
APA
Parker JT, McCoy MV.
(1929).
THE PRODUCTION AND TITRATION OF POTENT HORSE ANTIPNEUMOTOXIN.
J Exp Med, 50(1), 103-107.
https://doi.org/10.1084/jem.50.1.103 Publication
Researcher Affiliations
- Department of Pathology, College of Physicians and Surgeons, Columbia University, New York.
References
This article includes 2 references
- J Exp Med. 1928 Oct 31;48(5):695-707
- J Exp Med. 1929 Mar 31;49(4):695-700
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