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Home / Equine Research Bank / Can Vet J / The rapid and effective administration of a beta 2-agonist t...
The Canadian veterinary journal = La revue veterinaire canadienne1994; 35(3); 170-173;

The rapid and effective administration of a beta 2-agonist to horses with heaves using a compact inhalation device and metered-dose inhalers.

Abstract: The purpose of the study was to administer therapeutic aerosol generated by metered-dose inhalers to horses exhibiting clinical signs of heaves using a compact inhalation device developed for human medicine. It was fitted to a custom face mask in order to study the effect of an inhaled beta 2-agonist, fenoterol. Pulmonary function testing was performed on six horses following an acute exacerbation of heaves, characterized by tachypnea, wheezes, crackles, and spasmodic cough. Horses inhaled fenoterol in 1 mg increments administered as one 200 microgram puff every 5-10 s with the recording of data 5 min after the cessation of drug inhalation. A significant effect of fenoterol was shown for maximum change in transpulmonary pressure, dynamic compliance, lung resistance, and work of breathing, and the wheezes and crackles disappeared when auscultation was performed at the end of the test. This study demonstrates a novel, highly effective method for the rapid administration of inhaled medication in horses.
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Publication Date: 1994-03-01 PubMed ID: 8055432PubMed Central: PMC1686335
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research tested a new method to quickly deliver aerosol medication to horses suffering from heaves, using a compact inhalation device designed for humans. The medication, a beta 2-agonist called fenoterol, had a significant effect, improving lung function and reducing symptoms in the horses.

Research Objective

  • The research aimed to test the effectiveness of administering aerosol medication to horses showing symptoms of heaves, a respiratory disease, using a compact inhalation device typically utilized in human medicine. The medication used in this study was an inhaled beta 2-agonist, fenoterol.

Research Methodology

  • Six horses that had experienced an acute exacerbation of heaves (with symptoms such as tachypnea, wheezes, crackles, and spasmodic cough) were selected for the study.
  • The inhalation device was fitted to a custom face mask for each horse. The medication was then administered in 1 mg increments with each puff of the inhaler containing 200 micrograms of fenoterol.
  • Each administration was followed by a 5-10 seconds rest period, and data was recorded 5 minutes after the cessation of drug inhalation.

Results and Conclusion

  • The study showed a significant impact of fenoterol on several parameters – maximum change in transpulmonary pressure, dynamic compliance, lung resistance, and work of breathing. In addition, there was a disappearance of wheezes and crackles when auscultation was performed at the end of the test.
  • In conclusion, the study showed promising results for a new, more effective method for quickly delivering aerosol drugs to horses with heaves using a compact inhalation device. This device, usually used in human medicine, was adapted for use with horses and showed potential for improving treatment of respiratory diseases in equine veterinary practice.

Cite This Article

APA
Tesarowski DB, Viel L, McDonell WN, Newhouse MT. (1994). The rapid and effective administration of a beta 2-agonist to horses with heaves using a compact inhalation device and metered-dose inhalers. Can Vet J, 35(3), 170-173.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 35
Issue: 3
Pages: 170-173

Researcher Affiliations

Tesarowski, D B
  • Firestone Equine Respiratory Research Laboratory, Department of Clinical Studies, Ontario Veterinary College, University of Guelph.
Viel, L
    McDonell, W N
      Newhouse, M T

        MeSH Terms

        • Administration, Inhalation
        • Aerosols
        • Airway Obstruction / drug therapy
        • Airway Obstruction / veterinary
        • Analysis of Variance
        • Animals
        • Fenoterol / administration & dosage
        • Horse Diseases / drug therapy
        • Horses
        • Nebulizers and Vaporizers / veterinary
        • Respiratory Function Tests / veterinary

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        Citations

        This article has been cited 1 times.
        1. Mazan MR, Lascola K, Bruns SJ, Hoffman AM. Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol. Can J Vet Res 2014 Jul;78(3):214-20.
          pubmed: 24982553
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