The relationship between concentrations of vitamin D-binding protein (DBP) in serum and colostrum of mares and in serum of their foals in the neonatal period.
Abstract: Vitamin D-binding protein (DBP) participates in the actin scavenger system, it is a carrier of vitamin D and its derivatives, it manifests the capacity to bind mainly monounsaturated and saturated fatty acids, it binds to the surface of several cells and enhances chemotactic activity of C5a of the complement. The present study was aimed at answering the question whether serum DBP level in mares is related to levels of this protein in colostrum and in serum of its progeny. For this purpose, sera from 77 mares, colostra from 72 mares and sera from 69 Thoroughbred foals were collected. Mother's age, number of deliveries experienced in the past, month of delivery, feeding of foals with colostra were recorded. Blood of the foals was sampled from the umbilical vein during delivery (0h) and 36-48 h after delivery from the external jugular vein, colostra of the mares were obtained after delivery and blood of the mares was sampled 36-48 h after delivery. Concentration of DBP was estimated by a self-designed ELISA. In the present study, DBP concentrations in newborn's serum were found independent of their concentrations in mother's serum, her age and number of parities experienced in the past. Colostrum DBP level was found to be lower than that in the mare's serum and was not correlated to the concentration of this protein in mare's serum. There was no effect of colostrum feeding on DBP level in the foal serum. These results indicate that serum DBP concentration in newborn foals depends on factors which act directly on the foal. Because of the lack of correlation between plasma and colostrum concentrations of DBP, it can be assumed that DBP is synthesised in the mammary gland and/or specific transport mechanisms exist in the mammary gland.
Publication Date: 2010-02-23 PubMed ID: 20169924
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research investigates the relationship between the levels of vitamin D-binding protein (DBP) found in the serum and colostrum of mares, and in the serum of their newborn foals. The results show that the DBP concentration in newborn foals is influenced by factors unique to the foal, independently of their mother’s DBP levels, her age, or number of previous births.
Study Design
- The researchers aimed to understand whether the serum DBP level in mares is connected to the levels of this protein in colostrum (first milk produced during lactation) and in the serum of their offspring.
- The study included 77 mares for serum collection, 72 mares for colostrum collection, and 69 thoroughbred foals for blood sample collection. Various factors such as the mare’s age, their number of prior births, the delivery month, and the feeding of colostrum to the foals were considered.
- Blood from the foals was collected from the umbilical vein during birth, and from the external jugular vein 36-48 hours after birth. Colostrum was obtained from the mares after delivery, and their blood was sampled 36-48 hours after birth.
- The DBP concentration was measured using an enzyme-linked immunosorbent assay (ELISA), a test that checks for specific proteins in a sample.
Findings
- There was no dependency between the DBP concentrations in the serum of the newborn foals and those in the mother’s serum, her age, or the number of foals she had previously given birth to.
- The DBP level in colostrum had a lower concentration compared to the mare’s serum and showed no correlation with the mare’s serum levels.
- Feeding colostrum to the foals had no impact on the DBP level in their serum.
Conclusions
- The results indicate that serum DBP concentration in newborn foals is determined by factors that directly affect the foal, independently of the mare’s DBP levels, her age, or her number of prior births.
- The lack of connection between the plasma and colostrum levels of DBP suggests that this protein might be independently synthesized in the mammary gland or that there exists specific transportation mechanisms in the mammary gland, which regulate the levels of DBP in colostrum and blood.
Cite This Article
APA
Madej JP, Nowacki W, Boratyński J, Borkowski J, Włodarczyk-Szydłowska A, Musiał E.
(2010).
The relationship between concentrations of vitamin D-binding protein (DBP) in serum and colostrum of mares and in serum of their foals in the neonatal period.
Pol J Vet Sci, 12(4), 499-507.
Publication
Researcher Affiliations
- Department of Veterinary Prevention and Immunology, Department and Clinic of Obstetrics, Ruminant Diseases and Animal Health Care, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Norwida 31, 50-375 Wrocław, Poland. jan_madej@interia.pl
MeSH Terms
- Animals
- Animals, Newborn / blood
- Colostrum / chemistry
- Female
- Horses / blood
- Horses / metabolism
- Parity
- Pregnancy
- Vitamin D-Binding Protein / analysis
- Vitamin D-Binding Protein / blood
Citations
This article has been cited 2 times.- Fernando M, Ellery SJ, Marquina C, Lim S, Naderpoor N, Mousa A. Vitamin D-Binding Protein in Pregnancy and Reproductive Health.. Nutrients 2020 May 20;12(5).
- Kamr AM, Dembek KA, Reed SM, Slovis NM, Zaghawa AA, Rosol TJ, Toribio RE. Vitamin D Metabolites and Their Association with Calcium, Phosphorus, and PTH Concentrations, Severity of Illness, and Mortality in Hospitalized Equine Neonates.. PLoS One 2015;10(6):e0127684.
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