The relationship between intestinal and oral mucosa microcirculation in anaesthetized horses.
Abstract: To compare alteration in intestinal blood flow in anaesthetized horses with changes in oral mucosa blood flow. Methods: Prospective, randomized clinical study. Methods: Eight warmblood horses. Methods: After induction with guaifenesin and ketamine, anaesthesia was maintained with isoflurane at 1.5 vol% in oxygen. The tissue blood flow was measured using laser Doppler flowmetry at the jejunum, colon, rectal mucosa, oesophageal mucosa and the oral mucosa. After three baseline measurements, blood flow was first increased by dobutamine infusion and thereafter decreased by increasing isoflurane concentration and all measurements repeated twice. anova was used for comparing the measured parameters to baseline and correlation between the different measurement localizations was examined using Pearson correlation (p < 0.05). Results: Microperfusion at all measurement sites increased significantly during dobutamine infusion and decreased significantly during high isoflurane concentration. There was a significant correlation between flow at the oral mucosa and flow at the jejunum (r = 0.77, p = 0.002), colon (r = 0.76, p < 0.001), rectal mucosa (r = 0.88, p < 0.001) and oesophageal mucosa (r = 0.83, p <0.001). Conclusions: Oral mucosa blood flow can be used in isoflurane anaesthetized horses to reflect changes of intestinal microcirculation.
Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.
Publication Date: 2017-08-18 PubMed ID: 29223560DOI: 10.1016/j.vaa.2017.07.005Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
Summary
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The study provides an analysis of the correlation between intestinal and oral mucosa blood flow in horses, anaesthetized with isoflurane. The findings indicated that monitoring oral mucosa blood flow can serve as an indicator for changes in intestinal microcirculation during anesthesia.
Research Methodology
- The research was a randomized clinical study of eight warmblood horses.
- The induction was performed with guaifenesin and ketamine, after which anesthesia was maintained with isoflurane at a concentration of 1.5 vol% in oxygen.
- The blood flow in various tissues, specifically the jejunum, colon, rectal mucosa, oesophageal mucosa, and oral mucosa was measured using laser Doppler flowmetry.
- Post the collection of baseline measurements, blood flow was manipulated with the infusion of dobutamine to increase it, followed by increasing concentrations of isoflurane to decrease it; these steps were repeated twice for consistency.
Statistical Analysis and Results
- The statistical analysis was conducted using ANOVA for comparing the recorded parameters to baseline measurements.
- Pearson correlation was performed to examine the relationship between the different measurement locations, with a significance level set at p < 0.05.
- During dobutamine infusion, the microperfusion levels at all measured sites significantly increased, conversely, they decreased significantly during high isoflurane concentration.
- A significant positive correlation was noted between the oral mucosa and the jejunum, colon, rectal mucosa, and oesophageal mucosa.
Conclusion
- The conclusion of this study was based on their finding of a significant correlation between flow at the oral mucosa and flow at different parts of the digestive tract.
- This suggests that by observing the blood flow changes in the oral mucosa, alterations in intestinal microcirculation can be inferred in horses under isoflurane anesthesia, which could have clinical implications in the monitoring and management of anesthetized horses.
Cite This Article
APA
Hopster K, Neudeck S, Wittenberg-Voges L, Kästner SB.
(2017).
The relationship between intestinal and oral mucosa microcirculation in anaesthetized horses.
Vet Anaesth Analg, 45(1), 78-81.
https://doi.org/10.1016/j.vaa.2017.07.005 Publication
Researcher Affiliations
- Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany. Electronic address: klaus.hopster@icloud.com.
- Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
- Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
- Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
MeSH Terms
- Anesthesia, Inhalation / adverse effects
- Anesthesia, Inhalation / methods
- Anesthesia, Inhalation / veterinary
- Anesthetics, Inhalation
- Animals
- Colon / blood supply
- Horses / physiology
- Intestinal Mucosa / blood supply
- Intestinal Mucosa / drug effects
- Isoflurane
- Jejunum / blood supply
- Microcirculation / drug effects
- Microcirculation / physiology
- Mouth Mucosa / blood supply
- Mouth Mucosa / drug effects
- Rectum / blood supply
Citations
This article has been cited 1 times.- Freccero F, Di Maio C, Mariella J, Lanci A, Castagnetti C, Hallowell G. Assessment of the microvascular perfusion using sidestream dark-field imaging in healthy newborn foals.. Vet Med Sci 2023 Jan;9(1):158-166.
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