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Veterinary immunology and immunopathology2008; 129(3-4); 158-160; doi: 10.1016/j.vetimm.2008.11.014

The role of leukocyte biology in laminitis.

Abstract: The underlying pathogenesis of laminitis clearly depends importantly on inflammatory processes that recruit leukocytes at an early stage in disease. The role of leukocytes in the initiation of laminitis, or as an intermediary factor is currently being investigated using a limited array of models, and future studies require both new reagent and model systems if we are to clearly define how leukocytes propagate this disease. The opportunities presented by this type of research could easily include new and powerful treatment and preventative modalities.
Publication Date: 2008-11-11 PubMed ID: 19091425DOI: 10.1016/j.vetimm.2008.11.014Google Scholar: Lookup
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Summary

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The research paper focuses on assessing the role of leukocytes, which are white blood cells, in the development and progression of laminitis, an inflammatory disease of the hoof in horses. The study is exploring leukocyte activity at the early stages of the disease to look for possible prevention and treatment strategies.

Research Objectives

  • The primary aim of this research is to investigate the role of leukocytes in initiating and progressing laminitis, a painful and potentially debilitating hoof condition often seen in horses.
  • The study is particularly interested in the behavioral patterns of these white blood cells during the early phases of the disease.

Methods and Approach

  • The research utilizes several models to study how leukocytes function in the onset of laminitis.
  • The authors acknowledge the limitations of their current model systems and call for the development of new reagents and model systems to more comprehensively explore leukocyte behavior in relation to laminitis.

Potential Impact and Future Research

  • The researchers believe that their study could pave the way for new treatment and prevention methods for laminitis.
  • They envision that future research, aided by more advanced tools and models, could provide further insights into the role of leukocytes in causing and furthering laminitis.

Cite This Article

APA
Lunn DP, Hurley DJ. (2008). The role of leukocyte biology in laminitis. Vet Immunol Immunopathol, 129(3-4), 158-160. https://doi.org/10.1016/j.vetimm.2008.11.014

Publication

ISSN: 0165-2427
NlmUniqueID: 8002006
Country: Netherlands
Language: English
Volume: 129
Issue: 3-4
Pages: 158-160

Researcher Affiliations

Lunn, D Paul
  • Department of Clinical Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523, USA. lunnp@colostate.edu
Hurley, David J

    MeSH Terms

    • Animals
    • Foot Diseases / immunology
    • Foot Diseases / pathology
    • Foot Diseases / veterinary
    • Hoof and Claw
    • Horse Diseases / immunology
    • Horse Diseases / pathology
    • Horses
    • Inflammation / immunology
    • Inflammation / pathology
    • Inflammation / veterinary
    • Leukocytes / cytology
    • Leukocytes / immunology

    Citations

    This article has been cited 2 times.
    1. Mouithys-Mickalad A, Storms N, Franck T, Ceusters J, de la Rebière de Pouyade G, Deby-Dupont G, Serteyn D. Effects of Juglone on Neutrophil Degranulation and Myeloperoxidase Activity Related to Equine Laminitis.. Front Vet Sci 2021;8:677675.
      doi: 10.3389/fvets.2021.677675pubmed: 34336974google scholar: lookup
    2. Martin EM, Till RL, Sheats MK, Jones SL. Misoprostol Inhibits Equine Neutrophil Adhesion, Migration, and Respiratory Burst in an In Vitro Model of Inflammation.. Front Vet Sci 2017;4:159.
      doi: 10.3389/fvets.2017.00159pubmed: 29034248google scholar: lookup