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The spectrum of antiviral activities of acyclovir in vitro and in vivo.
Abstract: In vitro sensitivity data suggest that acyclovir should be effective against clinical manifestations of herpes simplex virus types 1 and 2, varicella-zoster virus and possibly Epstein-Barr virus. The clinical potential against herpes simplex virus types 1 and 2 is further supported by results in animal models. Human cytomegalovirus and the veterinary herpes viruses, with the possible exception of equine herpes virus type 1, may be insufficiently sensitive to be amenable to treatment.
Publication Date: 1983-09-01 PubMed ID: 6313598DOI: 10.1093/jac/12.suppl_b.19Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article investigates the potential effectiveness of the drug acyclovir against different types of herpes virus, both in laboratory conditions and in living organisms, finding effectiveness in some types but not others.
Testing Acyclovir’s Effectiveness Against Different Viruses
- The study examines the effectiveness of acyclovir – a commonly used antiviral medication – on multiple types of viruses. Specifically, it has been focused on different types of herpes virus, such as herpes simplex virus types 1 and 2, varicella-zoster virus, Epstein-Barr virus, and equine herpes virus type 1.
- The sensitivity data are collected in vitro, or in a controlled environment outside of a living organism, typically done in laboratories with petri dishes or test tubes.
- The in-vitro sensitivity data suggest that acyclovir shows promise in treating certain types of herpes viruses, namely herpes simplex virus types 1 and 2, varicella-zoster virus, and possibly Epstein-Barr virus.
Insufficient Sensitivity in Certain Viruses
- On the other hand, the study finds that acyclovir might not be as effective against certain types of viruses.
- Specifically, human cytomegalovirus – a type of herpes virus – and several types of veterinary herpes viruses may not be adequately sensitive to treatment with acyclovir.
- The only possible exception within these types of herpes viruses might be equine herpes virus type 1, but further investigation would be necessary to confirm this.
Further Validation of Acyclovir’s Effectiveness
- The study’s findings are validated not just through in-vitro testing, but also through in-vivo testing conducted on animal models.
- In-vivo tests, or experiments done in living organisms, support the potential of acyclovir in treating herpes simplex virus types 1 and 2.
- These results suggest that acyclovir’s antiviral activities are effective in a clinical setting, at least against the types of herpes viruses mentioned.
Cite This Article
APA
Collins P.
(1983).
The spectrum of antiviral activities of acyclovir in vitro and in vivo.
J Antimicrob Chemother, 12 Suppl B, 19-27.
https://doi.org/10.1093/jac/12.suppl_b.19 Publication
Researcher Affiliations
MeSH Terms
- Acyclovir / pharmacology
- Animals
- Cytomegalovirus / drug effects
- Encephalitis / drug therapy
- Guinea Pigs
- Hepatitis B virus / drug effects
- Herpes Simplex / drug therapy
- Herpesvirus 1, Cercopithecine / drug effects
- Herpesvirus 3, Human / drug effects
- Herpesvirus 4, Human / drug effects
- Humans
- In Vitro Techniques
- Keratitis, Dendritic / drug therapy
- Mice
- Rabbits
- Recurrence
- Simplexvirus / drug effects
Citations
This article has been cited 20 times.- Kamble N, Reddy VRAP, Jackson B, Anjum FR, Ubachukwu CC, Patil A, Behboudi S. Inhibition of Marek's Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro. Viruses 2023 Jul 29;15(8).
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- Lathe R, Tzeng NS, Itzhaki R. Herpes Infections and Dementia: Rebutting Alternative Fact. Neurotherapeutics 2019 Jan;16(1):176-179.
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