The therapeutic activity, post-treatment fertility and safety of prostaglandin F2alpha-Tham salt in clinically anoestrous mares: a review.
Abstract: Of 275 mares receiving prostaglandin F2alpha-Tham salt for its luteolytic effect upon the corpus luteum, 231 (84 per cent) exhibited signs of oestrus (range 73-95 per cent). Some mares not exhibiting overt oestrus may, nevertheless, ovulate and post-treatment rectal palpation of mares apparently failing to respond is suggested in these cases. Of 210 mares for which subsequent history was available. 104 (49.5 per cent) became pregnant from breeding at the post-treatment oestrus that immediately followed the induced regression of the corpus luteum (range 42.2-55.5 per cent). Fertility is comparable at this oestrus to that of naturally occurring oestrus in Thoroughbred mares. Side effects with PGF2alpha-Tham are physiological responses to the prostaglandin and include various degrees of sweating, some hypermotility of the gastrointestinal tract, increased pulse and respiratory rates and, occasionally, abdominal discomfort. These signs only occur in a proportion of mares, are transitory in nature and are resolved without treatment. A brief review of a comprehensive toxicity study using 20-160 times the recommended dose level, daily for 8 days, concludes that PGF2alpha-Tham has a 20 times safety margin for a single injection.
Publication Date: 1976-04-01 PubMed ID: 770159DOI: 10.1111/j.2042-3306.1976.tb03297.xGoogle Scholar: Lookup
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Summary
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This study examines the effectiveness of prostaglandin F2alpha-Tham salt in treating mares with reproductive issues. Through this treatment, a significant percentage of the mares showed signs of ovulation, and about half of the mares treated were able to become pregnant following treatment. The study also found that the drug was safe to use with transitory side effects.
Prostaglandin F2alpha-Tham salt and its effects
- The study was conducted on 275 mares which were given prostaglandin F2alpha-Tham salt. This substance is known for its luteolytic effect, meaning it can break down the corpus luteum, an endocrine structure in females that forms after an ovum is released and helps in maintaining pregnancy.
- 231 of the mares, which is 84%, showed signs of oestrus or their reproductive cycle after being treated. The range for this response was between 73 to 95 %, which indicates a high level of effectiveness for this treatment.
- The researchers also speculated that mares that did not show noticeable oestrus signs could still ovulate. Therefore, they suggest post-treatment rectal palpation for these cases to check for any hidden responses.
Post-treatment Fertility and Safety
- Out of 210 mares whose subsequent health status was available, 104, or 49.5%, were found to be pregnant after breeding during the immediate post-treatment oestrus. This suggests that the treatment was successful in restoring reproductive capabilities in these mares.
- The study observes that the fertility rates are comparable to those exhibited during naturally occurring oestrus in Thoroughbred mares, indicating a high degree of effectiveness.
- Side effects were noted, but these were physiological responses, indicating that they were typical responses of the body to the prostaglandin. These symptoms included degrees of sweating, increased gastrointestinal activity, increased pulse and respiration rates, and occasional abdominal discomfort.
- Such side effects only occur in a proportion of the mares, are transitory in nature and resolve without any additional treatment.
- From the toxicity study that used from 20 to 160 times the recommended dosage level for eight days, it was concluded that PGF2alpha-Tham has a safety margin of twenty times for a single injection, making it a relatively safe treatment.
Cite This Article
APA
Nelson AM.
(1976).
The therapeutic activity, post-treatment fertility and safety of prostaglandin F2alpha-Tham salt in clinically anoestrous mares: a review.
Equine Vet J, 8(2), 75-77.
https://doi.org/10.1111/j.2042-3306.1976.tb03297.x Publication
Researcher Affiliations
MeSH Terms
- Anestrus / drug effects
- Animals
- Corpus Luteum / drug effects
- Diarrhea / chemically induced
- Diarrhea / veterinary
- Estrus / drug effects
- Female
- Fertility / drug effects
- Gastrointestinal Motility / drug effects
- Horse Diseases / chemically induced
- Horses / physiology
- Pregnancy
- Prostaglandins F / adverse effects
- Prostaglandins F / pharmacology
- Sweating / drug effects
- Tromethamine / pharmacology
Citations
This article has been cited 1 times.- Mitchell D, de Gannes R, Sugden EA. Prostaglandin F2alpha treatment of cyclic dysfunction in mares. Can Vet J 1976 Dec;17(12):301-7.
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