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Open veterinary journal2021; 11(1); 128-134; doi: 10.4314/ovj.v11i1.19

The treatment of articular cartilage injuries with mesenchymal stem cells in different animal species.

Abstract: One of the major problems observed in veterinary practice is articular cartilage injuries in animals. In terms of agriculture, it leads to their culling from the herd, even if they are highly productive animals. With companion animals, owners usually have to decide between euthanasia or long-term sometimes lifelong treatment of the injury by a veterinarian. The use of mesenchymal stem cells (MSCs) for the treatment of cartilage injury in veterinary medicine is based on the good results observed in preclinical studies, where large animals have been used as experimental models to study the regenerative activity of MSCs. According to the literature, MSCs in veterinary medicine have been used to treat cartilage injury of dogs and horses, whereas sheep and goats are generally models for reproducing the disease in preclinical experimental studies.
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Publication Date: 2021-02-16 PubMed ID: 33898294PubMed Central: PMC8057211DOI: 10.4314/ovj.v11i1.19Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article focuses on the use of mesenchymal stem cells (MSCs) as a treatment for articular cartilage injuries in various animal species, with a particular emphasis on veterinary medicine.

Introduction to the Problem

  • Articular cartilage injuries pose a significant challenge in the field of veterinary medicine. They often lead to severe consequences for both agricultural and companion animals where decisions to cull or euthanize are often made, thereby affecting productivity and emotional bonds respectively.
  • In agriculture, these injuries often mean removing otherwise productive animals from the herd. For companion animals, owners often face hard choices between euthanasia and extended veterinary treatment.

Mesenchymal Stem Cells as a Solution

  • The article suggests mesenchymal stem cells (MSCs) as a potential solution for treating these types of injuries in animals, based on encouraging results from preclinical studies.
  • Mesenchymal stem cells have demonstrated regenerative properties, making them ideal candidates for studying therapeutic strategies for cartilage injuries. These cells have the potential for self-renewal and the ability to differentiate into multiple types of cells, including those that form cartilage.

The Use of MSCs in Veterinary Medicine

  • In the field of veterinary medicine, MSCs are primarily applied to cartilage injury treatment in dogs and horses. These animal models are not only clinically relevant but also biologically similar to humans, offering valuable insights for human medicine too.
  • Meanwhile, preclinical studies often utilize sheep and goats as models to mimic the disease for research purposes. Using these animals allows for the reproduction of the disease under controlled conditions, aiding the development of potentially effective treatments.

In conclusion, the article presents the potential of MSCs as a promising avenue for treating articular cartilage injuries in veterinary practice. However, more research is needed to further explore the effectiveness and safety of this approach in diverse animal models.

Cite This Article

APA
Ganiev I, Alexandrova N, Aimaletdinov A, Rutland C, Malanyeva A, Rizvanov A, Zakirova E. (2021). The treatment of articular cartilage injuries with mesenchymal stem cells in different animal species. Open Vet J, 11(1), 128-134. https://doi.org/10.4314/ovj.v11i1.19

Publication

Open veterinary journal
ISSN: 2218-6050
NlmUniqueID: 101653182
Country: Libya
Language: English
Volume: 11
Issue: 1
Pages: 128-134

Researcher Affiliations

Ganiev, Ilnur
  • Institute of Fundamental Medicine and Biology of Kazan (Volga region) Federal University, Kazan, Russia.
Alexandrova, Natalia
  • Institute of Fundamental Medicine and Biology of Kazan (Volga region) Federal University, Kazan, Russia.
Aimaletdinov, Alexander
  • Institute of Fundamental Medicine and Biology of Kazan (Volga region) Federal University, Kazan, Russia.
Rutland, Catrin
  • School of Veterinary Medicine and Science, College Road, Sutton Bonington, University of Nottingham, Nottingham, UK.
Malanyeva, Albina
  • Institute of Fundamental Medicine and Biology of Kazan (Volga region) Federal University, Kazan, Russia.
Rizvanov, Albert
  • Institute of Fundamental Medicine and Biology of Kazan (Volga region) Federal University, Kazan, Russia.
Zakirova, Elena
  • Institute of Fundamental Medicine and Biology of Kazan (Volga region) Federal University, Kazan, Russia.

MeSH Terms

  • Animals
  • Cartilage Diseases / therapy
  • Cartilage Diseases / veterinary
  • Cartilage, Articular / injuries
  • Cats / injuries
  • Cattle / injuries
  • Dogs / injuries
  • Goats / injuries
  • Horses / injuries
  • Mesenchymal Stem Cell Transplantation / statistics & numerical data
  • Mesenchymal Stem Cell Transplantation / veterinary
  • Mesenchymal Stem Cells / cytology
  • Sheep, Domestic / injuries
  • Sus scrofa / injuries

Conflict of Interest Statement

The authors declare that there is no conflict of interest.

References

This article includes 39 references
  1. Abdalmula A, Dooley LM, Kaufman C, Washington EA, House JV, Blacklaws BA, Ghosh P, Itescu S, Bailey SR, Kimpton WG. Immunoselected STRO-3(+) mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis.. Stem Cell Res Ther 2017 Feb 7;8(1):22.
    pmc: PMC5297153pubmed: 28173831doi: 10.1186/s13287-016-0460-7google scholar: lookup
  2. Al Faqeh H, Nor Hamdan BM, Chen HC, Aminuddin BS, Ruszymah BH. The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model.. Exp Gerontol 2012 Jun;47(6):458-64.
    pubmed: 22759409doi: 10.1016/j.exger.2012.03.018google scholar: lookup
  3. Ando W, Heard BJ, Chung M, Nakamura N, Frank CB, Hart DA. Ovine synovial membrane-derived mesenchymal progenitor cells retain the phenotype of the original tissue that was exposed to in-vivo inflammation: evidence for a suppressed chondrogenic differentiation potential of the cells.. Inflamm Res 2012 Jun;61(6):599-608.
    pubmed: 22391623doi: 10.1007/s00011-012-0450-xgoogle scholar: lookup
  4. Ardanaz N, Vázquez FJ, Romero A, Remacha AR, Barrachina L, Sanz A, Ranera B, Vitoria A, Albareda J, Prades M, Zaragoza P, Martín-Burriel I, Rodellar C. Inflammatory response to the administration of mesenchymal stem cells in an equine experimental model: effect of autologous, and single and repeat doses of pooled allogeneic cells in healthy joints.. BMC Vet Res 2016 Mar 31;12:65.
    pmc: PMC4815220pubmed: 27029614doi: 10.1186/s12917-016-0692-xgoogle scholar: lookup
  5. Bornes TD, Adesida AB, Jomha NM. Articular Cartilage Repair with Mesenchymal Stem Cells After Chondrogenic Priming: A Pilot Study.. Tissue Eng Part A 2018 May;24(9-10):761-774.
    pubmed: 28982297doi: 10.1089/ten.tea.2017.0235google scholar: lookup
  6. Broeckx SY, Seys B, Suls M, Vandenberghe A, Mariën T, Adriaensen E, Declercq J, Van Hecke L, Braun G, Hellmann K, Spaas JH. Equine Allogeneic Chondrogenic Induced Mesenchymal Stem Cells Are an Effective Treatment for Degenerative Joint Disease in Horses.. Stem Cells Dev 2019 Mar 15;28(6):410-422.
    pmc: PMC6441287pubmed: 30623737doi: 10.1089/scd.2018.0061google scholar: lookup
  7. Caminal M, Fonseca C, Peris D, Moll X, Rabanal RM, Barrachina J, Codina D, García F, Cairó JJ, Gòdia F, Pla A, Vives J. Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in sheep.. N Biotechnol 2014 Sep 25;31(5):492-8.
    pubmed: 25063342doi: 10.1016/j.nbt.2014.07.004google scholar: lookup
  8. Duarte Campos DF, Drescher W, Rath B, Tingart M, Fischer H. Supporting Biomaterials for Articular Cartilage Repair.. Cartilage 2012 Jul;3(3):205-21.
    pmc: PMC4297118pubmed: 26069634doi: 10.1177/1947603512444722google scholar: lookup
  9. Feng C, Luo X, He N, Xia H, Lv X, Zhang X, Li D, Wang F, He J, Zhang L, Lin X, Lin L, Yin H, He J, Wang J, Cao W, Wang R, Zhou G, Wang W. Efficacy and Persistence of Allogeneic Adipose-Derived Mesenchymal Stem Cells Combined with Hyaluronic Acid in Osteoarthritis After Intra-articular Injection in a Sheep Model.. Tissue Eng Part A 2018 Feb;24(3-4):219-233.
    pubmed: 28486025doi: 10.1089/ten.tea.2017.0039google scholar: lookup
  10. Francis SL, Di Bella C, Wallace GG, Choong PFM. Cartilage Tissue Engineering Using Stem Cells and Bioprinting Technology-Barriers to Clinical Translation.. Front Surg 2018;5:70.
    pmc: PMC6278684pubmed: 30547034doi: 10.3389/fsurg.2018.00070google scholar: lookup
  11. Frisbie DD, Cross MW, McIlwraith CW. A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee.. Vet Comp Orthop Traumatol 2006;19(3):142-6.
    pubmed: 16971996
  12. Frisbie DD, Kisiday JD, Kawcak CE, Werpy NM, McIlwraith CW. Evaluation of adipose-derived stromal vascular fraction or bone marrow-derived mesenchymal stem cells for treatment of osteoarthritis.. J Orthop Res 2009 Dec;27(12):1675-80.
    pubmed: 19544397doi: 10.1002/jor.20933google scholar: lookup
  13. Gao Y, Zhu Z, Zhao Y, Hua J, Ma Y, Guan W. Multilineage potential research of bovine amniotic fluid mesenchymal stem cells.. Int. J. Mol. Sci. 2015;15(3):698–710.
  14. González-Fernández ML, Pérez-Castrillo S, Sánchez-Lázaro JA, Prieto-Fernández JG, López-González ME, Lobato-Pérez S, Colaço BJ, Olivera ER, Villar-Suárez V. Assessment of regeneration in meniscal lesions by use of mesenchymal stem cells derived from equine bone marrow and adipose tissue.. Am J Vet Res 2016 Jul;77(7):779-88.
    pubmed: 27347833doi: 10.2460/ajvr.77.7.779google scholar: lookup
  15. Gugjoo MB, Sharma GT, Aithal HP, Kinjavdekar P. Cartilage tissue engineering: Role of mesenchymal stem cells along with growth factors & scaffolds.. Indian J Med Res 2016 Sep;144(3):339-347.
    pmc: PMC5320839pubmed: 28139532doi: 10.4103/0971-5916.198724google scholar: lookup
  16. St Jean G, Anderson DE. Decision analysis for fracture management in cattle.. Vet Clin North Am Food Anim Pract 2014 Mar;30(1):1-10, v.
    pubmed: 24534657doi: 10.1016/j.cvfa.2013.11.011google scholar: lookup
  17. Joswig AJ, Mitchell A, Cummings KJ, Levine GJ, Gregory CA, Smith R 3rd, Watts AE. Repeated intra-articular injection of allogeneic mesenchymal stem cells causes an adverse response compared to autologous cells in the equine model.. Stem Cell Res Ther 2017 Feb 28;8(1):42.
    pmc: PMC5329965pubmed: 28241885doi: 10.1186/s13287-017-0503-8google scholar: lookup
  18. Juneau C, Paine R, Chicas E, Gardner E, Bailey L, McDermott J. Current Concepts in Treatment of Patellofemoral Osteochondritis Dissecans.. Int J Sports Phys Ther 2016 Dec;11(6):903-925.
    pmc: PMC5095943pubmed: 27904793
  19. Jurgens WJ, Kroeze RJ, Zandieh-Doulabi B, van Dijk A, Renders GA, Smit TH, van Milligen FJ, Ritt MJ, Helder MN. One-step surgical procedure for the treatment of osteochondral defects with adipose-derived stem cells in a caprine knee defect: a pilot study.. Biores Open Access 2013 Aug;2(4):315-25.
    pmc: PMC3731690pubmed: 23914338doi: 10.1089/biores.2013.0024google scholar: lookup
  20. Kazemi D, Shams Asenjan K, Dehdilani N, Parsa H. Canine articular cartilage regeneration using mesenchymal stem cells seeded on platelet rich fibrin: Macroscopic and histological assessments.. Bone Joint Res 2017 Feb;6(2):98-107.
    pmc: PMC5331179pubmed: 28235767doi: 10.1302/2046-3758.62.bjr-2016-0188.r1google scholar: lookup
  21. Kim SE, Pozzi A, Yeh JC, Lopez-Velazquez M, Au Yong JA, Townsend S, Dunlap AE, Christopher SA, Lewis DD, Johnson MD, Petrucci K. Intra-Articular Umbilical Cord Derived Mesenchymal Stem Cell Therapy for Chronic Elbow Osteoarthritis in Dogs: A Double-Blinded, Placebo-Controlled Clinical Trial.. Front Vet Sci 2019;6:474.
    pmc: PMC6932969pubmed: 31921927doi: 10.3389/fvets.2019.00474google scholar: lookup
  22. Kovac M, Litvin YA, Aliev RO, Zakirova EY, Rutland CS, Kiyasov AP, Rizvanov AA. Gene Therapy Using Plasmid DNA Encoding VEGF164 and FGF2 Genes: A Novel Treatment of Naturally Occurring Tendinitis and Desmitis in Horses.. Front Pharmacol 2018;9:978.
    pmc: PMC6127648pubmed: 30233367doi: 10.3389/fphar.2018.00978google scholar: lookup
  23. Kriston-Pál É, Czibula Á, Gyuris Z, Balka G, Seregi A, Sükösd F, Süth M, Kiss-Tóth E, Haracska L, Uher F, Monostori É. Characterization and therapeutic application of canine adipose mesenchymal stem cells to treat elbow osteoarthritis.. Can J Vet Res 2017 Jan;81(1):73-78.
    pmc: PMC5220603pubmed: 28197017
  24. McIlwraith CW, Frisbie DD, Rodkey WG, Kisiday JD, Werpy NM, Kawcak CE, Steadman JR. Evaluation of intra-articular mesenchymal stem cells to augment healing of microfractured chondral defects.. Arthroscopy 2011 Nov;27(11):1552-61.
    pubmed: 21862278doi: 10.1016/j.arthro.2011.06.002google scholar: lookup
  25. Mount NM, Ward SJ, Kefalas P, Hyllner J. Cell-based therapy technology classifications and translational challenges.. Philos Trans R Soc Lond B Biol Sci 2015 Oct 19;370(1680):20150017.
    pmc: PMC4634004pubmed: 26416686doi: 10.1098/rstb.2015.0017google scholar: lookup
  26. Nifontov KR. Morphofunctional characteristic and the ways of the destructive joint changes correction in the sports horses: experimental-clinical investigation. Moscow, Russia: 2009.
  27. Pigareva YV. Clinical and morphological substantiation of efficiency of platelet-enriched autoplasm use at aseptic dog osteoarthritis. Saratov, Russia: 2016.
  28. Ragni E, Perucca Orfei C, De Luca P, Mondadori C, Viganò M, Colombini A, de Girolamo L. Inflammatory priming enhances mesenchymal stromal cell secretome potential as a clinical product for regenerative medicine approaches through secreted factors and EV-miRNAs: the example of joint disease.. Stem Cell Res Ther 2020 Apr 28;11(1):165.
    pmc: PMC7189600pubmed: 32345351doi: 10.1186/s13287-020-01677-9google scholar: lookup
  29. Redman SN, Oldfield SF, Archer CW. Current strategies for articular cartilage repair.. Eur Cell Mater 2005 Apr 14;9:23-32; discussion 23-32.
    pubmed: 15830323doi: 10.22203/ecm.v009a04google scholar: lookup
  30. Shah K, Drury T, Roic I, Hansen P, Malin M, Boyd R, Sumer H, Ferguson R. Outcome of Allogeneic Adult Stem Cell Therapy in Dogs Suffering from Osteoarthritis and Other Joint Defects.. Stem Cells Int 2018;2018:7309201.
    pmc: PMC6046133pubmed: 30050578doi: 10.1155/2018/7309201google scholar: lookup
  31. Tiwary R, Amarpal, Aithal HP, Kinjavdekar P, Pawde AM, Singh R. Effect of IGF-1 and Uncultured Autologous Bone-Marrow-Derived Mononuclear Cells on Repair of Osteochondral Defect in Rabbits.. Cartilage 2014 Jan;5(1):43-54.
    pmc: PMC4297094pubmed: 26069684doi: 10.1177/1947603513499366google scholar: lookup
  32. Toh WS, Brittberg M, Farr J, Foldager CB, Gomoll AH, Hui JH, Richardson JB, Roberts S, Spector M. Cellular senescence in aging and osteoarthritis.. Acta Orthop 2016 Dec;87(sup363):6-14.
    pmc: PMC5389431pubmed: 27658487doi: 10.1080/17453674.2016.1235087google scholar: lookup
  33. Vega A, Martín-Ferrero MA, Del Canto F, Alberca M, García V, Munar A, Orozco L, Soler R, Fuertes JJ, Huguet M, Sánchez A, García-Sancho J. Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial.. Transplantation 2015 Aug;99(8):1681-90.
    pubmed: 25822648doi: 10.1097/tp.0000000000000678google scholar: lookup
  34. Vilar JM, Batista M, Morales M, Santana A, Cuervo B, Rubio M, Cugat R, Sopena J, Carrillo JM. Assessment of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells in osteoarthritic dogs using a double blinded force platform analysis.. BMC Vet Res 2014 Jul 1;10:143.
    pmc: PMC4085658pubmed: 24984756doi: 10.1186/1746-6148-10-143google scholar: lookup
  35. Wilke MM, Nydam DV, Nixon AJ. Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine model.. J Orthop Res 2007 Jul;25(7):913-25.
    pubmed: 17405160doi: 10.1002/jor.20382google scholar: lookup
  36. Zakirova EY, Valeeva AN, Aimaletdinov AM, Nefedovskaya LV, Akhmetshin RF, Rutland CS, Rizvanov AA. Potential therapeutic application of mesenchymal stem cells in ophthalmology.. Exp Eye Res 2019 Dec;189:107863.
    pubmed: 31669045doi: 10.1016/j.exer.2019.107863google scholar: lookup
  37. Zakirova EYu, Valeeva AN, Masgutov RF, Naumenko EA, Rizvanov AA. Application of allogenic adipose-derived multipotent mesenchymal stromal cells from cat for tibial bone pseudoarthrosis therapy (Case Report). BioNanoScience 2017;7:207–211.
  38. Zayed M, Adair S, Ursini T, Schumacher J, Misk N, Dhar M. Concepts and challenges in the use of mesenchymal stem cells as a treatment for cartilage damage in the horse.. Res Vet Sci 2018 Jun;118:317-323.
    pubmed: 29601969doi: 10.1016/j.rvsc.2018.03.011google scholar: lookup
  39. Zayed MN, Schumacher J, Misk N, Dhar MS. Effects of pro-inflammatory cytokines on chondrogenesis of equine mesenchymal stromal cells derived from bone marrow or synovial fluid.. Vet J 2016 Nov;217:26-32.
    pubmed: 27810206doi: 10.1016/j.tvjl.2016.05.014google scholar: lookup

Citations

This article has been cited 1 times.
  1. Dias IE, Viegas CA, Requicha JF, Saavedra MJ, Azevedo JM, Carvalho PP, Dias IR. Mesenchymal Stem Cell Studies in the Goat Model for Biomedical Research-A Review of the Scientific Literature. Biology (Basel) 2022 Aug 27;11(9).
    doi: 10.3390/biology11091276pubmed: 36138755google scholar: lookup
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