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Home / Equine Research Bank / Open Vet J / The treatment of articular cartilage injuries with mesenchym...
Open veterinary journal2021; 11(1); 128-134; doi: 10.4314/ovj.v11i1.19

The treatment of articular cartilage injuries with mesenchymal stem cells in different animal species.

Abstract: One of the major problems observed in veterinary practice is articular cartilage injuries in animals. In terms of agriculture, it leads to their culling from the herd, even if they are highly productive animals. With companion animals, owners usually have to decide between euthanasia or long-term sometimes lifelong treatment of the injury by a veterinarian. The use of mesenchymal stem cells (MSCs) for the treatment of cartilage injury in veterinary medicine is based on the good results observed in preclinical studies, where large animals have been used as experimental models to study the regenerative activity of MSCs. According to the literature, MSCs in veterinary medicine have been used to treat cartilage injury of dogs and horses, whereas sheep and goats are generally models for reproducing the disease in preclinical experimental studies.
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Publication Date: 2021-02-16 PubMed ID: 33898294PubMed Central: PMC8057211DOI: 10.4314/ovj.v11i1.19Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article focuses on the use of mesenchymal stem cells (MSCs) as a treatment for articular cartilage injuries in various animal species, with a particular emphasis on veterinary medicine.

Introduction to the Problem

  • Articular cartilage injuries pose a significant challenge in the field of veterinary medicine. They often lead to severe consequences for both agricultural and companion animals where decisions to cull or euthanize are often made, thereby affecting productivity and emotional bonds respectively.
  • In agriculture, these injuries often mean removing otherwise productive animals from the herd. For companion animals, owners often face hard choices between euthanasia and extended veterinary treatment.

Mesenchymal Stem Cells as a Solution

  • The article suggests mesenchymal stem cells (MSCs) as a potential solution for treating these types of injuries in animals, based on encouraging results from preclinical studies.
  • Mesenchymal stem cells have demonstrated regenerative properties, making them ideal candidates for studying therapeutic strategies for cartilage injuries. These cells have the potential for self-renewal and the ability to differentiate into multiple types of cells, including those that form cartilage.

The Use of MSCs in Veterinary Medicine

  • In the field of veterinary medicine, MSCs are primarily applied to cartilage injury treatment in dogs and horses. These animal models are not only clinically relevant but also biologically similar to humans, offering valuable insights for human medicine too.
  • Meanwhile, preclinical studies often utilize sheep and goats as models to mimic the disease for research purposes. Using these animals allows for the reproduction of the disease under controlled conditions, aiding the development of potentially effective treatments.

In conclusion, the article presents the potential of MSCs as a promising avenue for treating articular cartilage injuries in veterinary practice. However, more research is needed to further explore the effectiveness and safety of this approach in diverse animal models.

Cite This Article

APA
Ganiev I, Alexandrova N, Aimaletdinov A, Rutland C, Malanyeva A, Rizvanov A, Zakirova E. (2021). The treatment of articular cartilage injuries with mesenchymal stem cells in different animal species. Open Vet J, 11(1), 128-134. https://doi.org/10.4314/ovj.v11i1.19

Publication

Open veterinary journal
ISSN: 2218-6050
NlmUniqueID: 101653182
Country: Libya
Language: English
Volume: 11
Issue: 1
Pages: 128-134

Researcher Affiliations

Ganiev, Ilnur
  • Institute of Fundamental Medicine and Biology of Kazan (Volga region) Federal University, Kazan, Russia.
Alexandrova, Natalia
  • Institute of Fundamental Medicine and Biology of Kazan (Volga region) Federal University, Kazan, Russia.
Aimaletdinov, Alexander
  • Institute of Fundamental Medicine and Biology of Kazan (Volga region) Federal University, Kazan, Russia.
Rutland, Catrin
  • School of Veterinary Medicine and Science, College Road, Sutton Bonington, University of Nottingham, Nottingham, UK.
Malanyeva, Albina
  • Institute of Fundamental Medicine and Biology of Kazan (Volga region) Federal University, Kazan, Russia.
Rizvanov, Albert
  • Institute of Fundamental Medicine and Biology of Kazan (Volga region) Federal University, Kazan, Russia.
Zakirova, Elena
  • Institute of Fundamental Medicine and Biology of Kazan (Volga region) Federal University, Kazan, Russia.

MeSH Terms

  • Animals
  • Cartilage Diseases / therapy
  • Cartilage Diseases / veterinary
  • Cartilage, Articular / injuries
  • Cats / injuries
  • Cattle / injuries
  • Dogs / injuries
  • Goats / injuries
  • Horses / injuries
  • Mesenchymal Stem Cell Transplantation / statistics & numerical data
  • Mesenchymal Stem Cell Transplantation / veterinary
  • Mesenchymal Stem Cells / cytology
  • Sheep, Domestic / injuries
  • Sus scrofa / injuries

Conflict of Interest Statement

The authors declare that there is no conflict of interest.

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Citations

This article has been cited 1 times.
  1. Dias IE, Viegas CA, Requicha JF, Saavedra MJ, Azevedo JM, Carvalho PP, Dias IR. Mesenchymal Stem Cell Studies in the Goat Model for Biomedical Research-A Review of the Scientific Literature.. Biology (Basel) 2022 Aug 27;11(9).
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