The use of amniotic membrane transplantation for ocular surface reconstruction: a review and series of 58 equine clinical cases (2002-2008).
Abstract: Amniotic membrane transplantation (AMT) is an effective clinical therapy for reconstruction of the ocular surface in human and veterinary patients. Amnion is avascular and strong, contains antiangiogenic and antiinflammatory properties and growth factors, and has properties that prevent or decrease fibrosis in healing tissue. Indications for its use are steadily growing and include grafting to replace diseased, missing or excised tissue, patching to support diseased tissue during the healing process and as a substrate for the expansion of epithelial cells for transplantation to the cornea. AMT through a combination of mechanical and biologic factors can preserve the integrity of the globe, optimize the visual outcome, and minimize scarring in severely diseased corneas.
Publication Date: 2009-11-26 PubMed ID: 19891647DOI: 10.1111/j.1463-5224.2009.00741.xGoogle Scholar: Lookup
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- Journal Article
- Review
Summary
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The research article discusses the efficiency of Amniotic Membrane Transplantation (AMT) in reconstructing ocular surface in human and veterinary patients, supported by a series of equine clinical cases from 2002 to 2008.
Research Objectives and Findings
- The primary objective of the research is to explore the effectiveness of Amniotic Membrane Transplantation (AMT) in ocular surface reconstruction, primarily in veterinary medicine involving horses. The study is based on 58 equine clinical cases undertaken from 2002 to 2008.
- The research findings suggest that AMT is an efficient clinical therapy. The amnion, a part majorly involved in the transplantation is avascular (lacking blood vessels), strong, and packed with anti-inflammatory and antiangiogenic properties.
- Additionally, amnion comes endowed with growth factors and certain properties that deter or reduce fibrosis, an abnormal thickening, and scarring of connective tissues, in the healing tissue.
Applications and Implications
- The application of AMT has been growing. The indications of its usage comprise grafting to replace excised, missing, or diseased tissue. This therapy is also used as patching to support the diseased tissue during the healing process, and as a substrate for the growth of epithelial cells for transplanting to the cornea.
- Through mechanical and biological factors, AMT can maintain the integrity of the globe, optimize the visual outcome and lessen scarring in severely diseased corneas, demonstrating substantial implications in ocular surface reconstruction.
Conclusion
- This research study advocates the use of AMT for ocular surface reconstruction in both human and equine patients. The series of clinical cases between 2002 and 2008 further support its effectiveness and broadens the scope of AMT application in veterinary medicine.
Cite This Article
APA
Plummer CE, Ollivier F, Kallberg M, Brooks D, Barrie K, Utter M, Gelatt K.
(2009).
The use of amniotic membrane transplantation for ocular surface reconstruction: a review and series of 58 equine clinical cases (2002-2008).
Vet Ophthalmol, 12 Suppl 1, 17-24.
https://doi.org/10.1111/j.1463-5224.2009.00741.x Publication
Researcher Affiliations
- College of Veterinary Medicine, University of Florida, Department of Small Animal Clinical Sciences, Gainesville, FL, [corrected] USA. plummerc@mail.vetmed.ufl.edu
MeSH Terms
- Amnion / transplantation
- Animals
- Biological Dressings
- Corneal Diseases / therapy
- Horse Diseases / therapy
- Horses
Citations
This article has been cited 12 times.- Ranaei A, Chavoshi A, Aghamollaei H, Naderi M, Agha Alishiri A, Jadidi KH. The Effect of Amniotic Membrane Extracted Eye Drop on Repairing The Corneal Epithelial in Patients after Trans-Epithelial Photorefractive Keratectomy: An Interventional and Historical Study.. Cell J 2023 Apr 1;25(4):217-221.
- Rosa MVD, Rosa M, Botteon PTL. Cryopreserved equine amniotic membrane and its use in cutaneous wounds of horses.. Braz J Vet Med 2022;44:e003122.
- Hisey EA, Martins BC, Donnelly CG, Cassano JM, Katzman SA, Murphy CJ, Thomasy SM, Leonard BC. Identification of putative orthologs of clinically relevant antimicrobial peptides in the equine ocular surface and amniotic membrane.. Vet Ophthalmol 2023 Apr;26 Suppl 1(Suppl 1):125-133.
- Lohajaroensub R, Sawangmake C, Rodkhum C, Tuntivanich N. Expression of Antimicrobial Peptide Genes in the Canine Amniotic Membrane.. Vet Sci 2022 Apr 21;9(5).
- Withavatpongtorn N, Tuntivanich N. Characterization of Cryopreserved Canine Amniotic Membrane.. Membranes (Basel) 2021 Oct 27;11(11).
- Dadkhah Tehrani F, Firouzeh A, Shabani I, Shabani A. A Review on Modifications of Amniotic Membrane for Biomedical Applications.. Front Bioeng Biotechnol 2020;8:606982.
- Villar T, Pascoli AL, Chaulagain S, Fadl-Alla BA, Martins BC. Evaluation of pigment epithelium-derived factor concentration in equine amniotic membrane homogenate and its in-vitro vascular endothelial growth factor inhibition effect in tears of dogs with vascularized ulcerative keratitis.. Open Vet J 2020 Oct;10(3):289-296.
- Lores M, Rakestraw P, De Rijck M, Yarbrough T. Use of autologous fascia lata graft to repair a complex corneal ulcer in a mare.. Ir Vet J 2020;73:7.
- Shayan Asl N, Nejat F, Mohammadi P, Nekoukar A, Hesam S, Ebrahimi M, Jadidi K. Amniotic Membrane Extract Eye Drop Promotes Limbal Stem Cell Proliferation and Corneal Epithelium Healing.. Cell J 2019 Jan;20(4):459-468.
- Barboni B, Russo V, Berardinelli P, Mauro A, Valbonetti L, Sanyal H, Canciello A, Greco L, Muttini A, Gatta V, Stuppia L, Mattioli M. Placental Stem Cells from Domestic Animals: Translational Potential and Clinical Relevance.. Cell Transplant 2018 Jan;27(1):93-116.
- Vidane AS, Souza AF, Sampaio RV, Bressan FF, Pieri NC, Martins DS, Meirelles FV, Miglino MA, Ambrósio CE. Cat amniotic membrane multipotent cells are nontumorigenic and are safe for use in cell transplantation.. Stem Cells Cloning 2014;7:71-8.
- Albert R, Veréb Z, Csomós K, Moe MC, Johnsen EO, Olstad OK, Nicolaissen B, Rajnavölgyi E, Fésüs L, Berta A, Petrovski G. Cultivation and characterization of cornea limbal epithelial stem cells on lens capsule in animal material-free medium.. PLoS One 2012;7(10):e47187.
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