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HSS journal : the musculoskeletal journal of Hospital for Special Surgery2018; 15(1); 96-99; doi: 10.1007/s11420-018-9647-z

The Use of Bone Marrow Concentrate in the Treatment of Full-Thickness Chondral Defects.

Abstract: This article is a critical analysis of a study, "Minimally Manipulated Bone Marrow Concentrate Compared with Microfracture Treatment of Full-Thickness Chondral Defects: A One-Year Study in an Equine Model," by Chu et al. (. 100(2):138-146, 2018). The investigation compared two interventions in the management of full-thickness chondral defects in an equine model: autologous bone marrow concentrate without concomitant microfracture treatment versus microfracture treatment alone. This review analyzes the methodology and results of their investigation and examines how their findings may influence the continued development of therapeutic options for full-thickness cartilage injuries. The study utilized in vitro analysis, arthroscopic assessment, magnetic resonance imaging (MRI) evaluation, and histological analysis to compare the treatments and their influence on the quality of cartilage repair. Although Chu et al. reported similar results between groups, their findings offer insight into the role of arthroscopy, MRI, and histology in the evaluation of repair quality. We compare their findings to those of similar investigations, highlighting the limited therapeutic options and variable clinical outcomes related to the treatment of full-thickness articular cartilage defects.
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Publication Date: 2018-11-26 PubMed ID: 30863240PubMed Central: PMC6384207DOI: 10.1007/s11420-018-9647-zGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study is a critical look into the treatment options for full-thickness cartilage injuries, specifically looking at bone marrow concentrates and microfracture treatment.

Research Overview

  • The research is an analysis of a study by Chu et al. which tested two treatment methods for full-thickness chondral defects in horses.
  • The treatment methods were autologous bone marrow concentrate, which is a patient’s own bone marrow, without additional microfracture treatment versus microfracture treatment alone.

Research Methodology

  • The research used various ways to compare the quality of cartilage repair between the two treatment options, including in vitro analysis, arthroscopic assessment, MRI evaluation, and histological analysis.

Research Findings

  • The study found similar results between both treatment groups; Chu et al.’s findings shed light on the importance of arthroscopy, MRI, and histology in assessing the quality of repair in cartilage injuries.
  • This analysis is then compared with findings from comparable investigations. These comparisons highlight the limited therapeutic options and the varying clinical outcomes in relation to the treatment of full-thickness articular cartilage defects.

Implications of the Study

  • Although the study did not heavily favor one treatment over the other, its findings and methods may influence the development of other therapeutic options for full-thickness cartilage injuries in the future.
  • Additionally, the study also emphasized the importance of using multiple assessment methods (viz., arthroscopy, MRI, and histology) for a more comprehensive and accurate evaluation of treatment outcomes.

Cite This Article

APA
Apostolakos JM, Lazaro L, Williams RJ. (2018). The Use of Bone Marrow Concentrate in the Treatment of Full-Thickness Chondral Defects. HSS J, 15(1), 96-99. https://doi.org/10.1007/s11420-018-9647-z

Publication

HSS journal : the musculoskeletal journal of Hospital for Special Surgery
ISSN: 1556-3316
NlmUniqueID: 101273938
Country: United States
Language: English
Volume: 15
Issue: 1
Pages: 96-99

Researcher Affiliations

Apostolakos, John M
  • Department of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021 USA.
Lazaro, Lionel
  • Department of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021 USA.
Williams, Riley J
  • Department of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021 USA.

Conflict of Interest Statement

John M. Apostolakos, MD, MPH, and Lionel Lazaro, MD, declare that they have no conflicts of interest. Riley J. Williams, MD, reports receiving intellectual property royalties from and being a paid consultant to Arthrex, Inc.; owning stock or stock options in Cymedica, Inc., Pristine Surgical, R2T2 Laboratories, Inc., and RecoverX; receiving research support from Histogenics, Inc.; being a paid consultant to JRF Ortho and an unpaid consultant to R2T2 Laboratories, Inc.; and receiving publishing royalties from Springer.N/AN/ADisclosure forms provided by the authors are available with the online version of this article.

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Citations

This article has been cited 1 times.
  1. Canonici F, Cocumelli C, Cersini A, Marcoccia D, Zepparoni A, Altigeri A, Caciolo D, Roncoroni C, Monteleone V, Innocenzi E, Alimonti C, Ghisellini P, Rando C, Pechkova E, Eggenhöffner R, Scicluna MT, Barbaro K. Articular Cartilage Regeneration by Hyaline Chondrocytes: A Case Study in Equine Model and Outcomes. Biomedicines 2023 May 31;11(6).
    doi: 10.3390/biomedicines11061602pubmed: 37371697google scholar: lookup
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