FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Theriogenology / The use of dexamethasone administered to mares at breeding t...
Theriogenology2008; 70(7); 1093-1100; doi: 10.1016/j.theriogenology.2008.06.029

The use of dexamethasone administered to mares at breeding time in the modulation of persistent mating induced endometritis.

Abstract: The present study describes the effect of a single dose of dexamethasone administered to mares at time of breeding. In an initial experiment, the authors investigated safety of treatment. In a second experiment the effect of treatment on the uterine environment, fetal development and pregnancy outcome was examined. In the final part of the study, mares susceptible to persistent mating induced endometritis were identified, by means of a risk factor score system and the effect of treatment evaluated. Results indicated that dexamethasone administered at breeding time did not negatively impact on mares medical and reproductive traits. A reduced inflammatory response was observed post-mating in treated versus control mares and mares with multiple risk factors for susceptibility to persistent mating induced endometritis showed improved pregnancy rates following treatment. The authors concluded that a single dose of dexamethasone administered at the time of breeding is safe and can be used to modulate the uterine inflammatory response to breeding in susceptible mares.
Get Full Text
Publication Date: 2008-07-22 PubMed ID: 18649933DOI: 10.1016/j.theriogenology.2008.06.029Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Controlled Clinical Trial
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper in focus explores the effects of administering dexamethasone, a type of steroid, to mares at breeding time and its impact on persistent mating induced endometritis.

Objective and Methodology

  • The study intends to understand the implications of dexamethasone when given to mares during the time of breeding with a particular emphasis on persistent mating induced endometritis, which is inflammation of the inner layer of the uterus.
  • The researchers conducted three experiments. Initially, they examined the safety of this treatment. Then, they observed how the medication influenced the uterine environment, fetal development, and pregnancy outcomes. Finally, they identified mares that are prone to persistent mating induced endometritis and evaluated the effects of dexamethasone on these specific mares.

Results and Conclusions

  • The results revealed that usage of dexamethasone at breeding time did not negatively influence the health and reproductive attributes of the mares.
  • The treated mares showed a reduced inflammatory response after breeding as compared to the control group.
  • The mares with high risk factors for susceptibility to persistent mating induced endometritis displayed improved pregnancy rates after treatment with dexamethasone.
  • The researchers concluded that a single dose of dexamethasone at the time of breeding is safe and can efficiently modulate and moderate the uterine inflammatory response to breeding in those mares that are susceptible to persistent mating induced endometritis.

Implicatons of the Study

  • The study suggests that dexamethasone can be used effectively during the breeding cycle, especially for mares that experience persistent mating induced endometritis.
  • Administering dexamethasone not only ensures the safety of the animal but also enhances pregnancy rates in susceptible mares, opening potential ways to deal with mating-induced complications and improve breeding success.

Cite This Article

APA
Bucca S, Carli A, Buckley T, Dolci G, Fogarty U. (2008). The use of dexamethasone administered to mares at breeding time in the modulation of persistent mating induced endometritis. Theriogenology, 70(7), 1093-1100. https://doi.org/10.1016/j.theriogenology.2008.06.029

Publication

Theriogenology
ISSN: 0093-691X
NlmUniqueID: 0421510
Country: United States
Language: English
Volume: 70
Issue: 7
Pages: 1093-1100

Researcher Affiliations

Bucca, S
  • Somerton Equine Hospital, Friarstown, Kildare, Co Kildare, Ireland. stefbucca@hotmail.com
Carli, A
    Buckley, T
      Dolci, G
        Fogarty, U

          MeSH Terms

          • Animals
          • Anti-Inflammatory Agents / administration & dosage
          • Anti-Inflammatory Agents / therapeutic use
          • Breeding
          • Dexamethasone / administration & dosage
          • Dexamethasone / therapeutic use
          • Drug Administration Schedule
          • Endometritis / prevention & control
          • Endometritis / veterinary
          • Female
          • Horse Diseases / prevention & control
          • Horses
          • Insemination, Artificial / veterinary
          • Risk Factors

          Citations

          This article has been cited 13 times.
          1. Tyrnenopoulou P, Fthenakis GC. Clinical Aspects of Bacterial Distribution and Antibiotic Resistance in the Reproductive System of Equids. Antibiotics (Basel) 2023 Mar 28;12(4).
            doi: 10.3390/antibiotics12040664pubmed: 37107026google scholar: lookup
          2. Scarlet D, Malama E, Fischer S, Knutti B, Bollwein H. Relationship between Clinical Uterine Findings, Therapy, and Fertility in the Mare. Vet Sci 2023 Mar 29;10(4).
            doi: 10.3390/vetsci10040259pubmed: 37104414google scholar: lookup
          3. Freccero F, Mislei B, Bucci D, Dondi F, Mari G. Effects of Intra-Uterine Fluid Accumulation after Artificial Insemination on Luteal Function in Mares. Animals (Basel) 2022 Dec 23;13(1).
            doi: 10.3390/ani13010067pubmed: 36611677google scholar: lookup
          4. Katila T, Ferreira-Dias G. Evolution of the Concepts of Endometrosis, Post Breeding Endometritis, and Susceptibility of Mares. Animals (Basel) 2022 Mar 19;12(6).
            doi: 10.3390/ani12060779pubmed: 35327176google scholar: lookup
          5. Bottrel M, Ortiz I, Hidalgo M, Díaz-Jiménez M, Pereira B, Consuegra C, Yousef MS, Dorado J. Hormonal Management for the Induction of Luteolysis and Ovulation in Andalusian Jennies: Effect on Reproductive Performance, Embryo Quality and Recovery Rate. Animals (Basel) 2022 Jan 8;12(2).
            doi: 10.3390/ani12020143pubmed: 35049767google scholar: lookup
          6. Dawod A, Miro J, Elbaz HT, Fahmy H, Abdoon AS. Effect of Intrauterine Infusion of Equine Fresh Platelets-Rich Plasma (PRP) or Lyophilized PRP (L-GF(equina)) on Ovarian Activity and Pregnancy Rate in Repeat Breeder Purebred Arabian Mares. Animals (Basel) 2021 Apr 14;11(4).
            doi: 10.3390/ani11041123pubmed: 33919901google scholar: lookup
          7. Wojtysiak K, Ryszka W, Stefaniak T, Król J, Kozdrowski R. Changes in the Secretion of Anti-Inflammatory Cytokines and Acute-Phase Proteins in the Uterus after Artificial Insemination in the Mare. Animals (Basel) 2020 Dec 19;10(12).
            doi: 10.3390/ani10122438pubmed: 33352707google scholar: lookup
          8. Köhne M, Kuhlmann M, Tönißen A, Martinsson G, Sieme H. Diagnostic and Treatment Practices of Equine Endometritis-A Questionnaire. Front Vet Sci 2020;7:547.
            doi: 10.3389/fvets.2020.00547pubmed: 32984410google scholar: lookup
          9. Canisso IF, Segabinazzi LGTM, Fedorka CE. Persistent Breeding-Induced Endometritis in Mares - a Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology. Int J Mol Sci 2020 Feb 20;21(4).
            doi: 10.3390/ijms21041432pubmed: 32093296google scholar: lookup
          10. Nash DM, Paddison J, Davies Morel MCG, Barnea ER. Preimplantation factor modulates acute inflammatory responses of equine endometrium. Vet Med Sci 2018 Nov;4(4):351-356.
            doi: 10.1002/vms3.126pubmed: 30273998google scholar: lookup
          11. Del Prete C, Attolini E, Merlo B, Iacono E, Nocera FP, De Martino L, Longobardi C, Damiano S, Longobardi V, Cocchia N, Pasolini MP. Post-Insemination Infusion of Wharton's Jelly Mesenchymal Stromal/Stem Cells-Derived Conditioned Medium: A Novel Approach for Improving Pregnancy Outcomes in Problem Mares. Vet Sci 2025 May 16;12(5).
            doi: 10.3390/vetsci12050482pubmed: 40431575google scholar: lookup
          12. Wang Z, Zeng S, Wang Y, Wang T, Qu H, Zhu Y, Li J. Reproductive Disorders in Donkeys: Current Evidence and Update. Animals (Basel) 2024 Aug 28;14(17).
            doi: 10.3390/ani14172494pubmed: 39272279google scholar: lookup
          13. Zdrojkowski Ł, Pawliński B, Skierbiszewska K, Jasiński T, Domino M. Assessment of Connective Tissue in the Equine Uterus and Cervix: Review of Clinical Impact and Staining Options. Animals (Basel) 2024 Jan 3;14(1).
            doi: 10.3390/ani14010156pubmed: 38200887google scholar: lookup
          Subscribe to our newsletter
          Join 99,357 horse owners like you who receive our email updates on horse health and nutrition.