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Home / Equine Research Bank / Vet Sci / The Use of Peptides in Veterinary Serodiagnosis of Infectiou...
Veterinary sciences2022; 9(10); 561; doi: 10.3390/vetsci9100561

The Use of Peptides in Veterinary Serodiagnosis of Infectious Diseases: A Review.

Abstract: Peptides constitute an alternative and interesting option to develop treatments, vaccines, and diagnostic tools as they demonstrate their scope in several health aspects; as proof of this, commercial peptides for humans and animals are available on the market and used daily. This review aimed to know the role of peptides in the field of veterinary diagnosis, and include peptide-based enzyme-linked immunosorbent assay (pELISA), lateral flow devices, and peptide latex agglutination tests that have been developed to detect several pathogens including viruses and bacteria of health and production relevance in domestic animals. Studies in cattle, small ruminants, dogs, cats, poultry, horses, and even aquatic organisms were reviewed. Different studies showed good levels of sensitivity and specificity against their target, moreover, comparisons with commercial kits and official tests were performed which allowed appraising their performance. Chemical synthesis, recombinant DNA technology, and enzymatic synthesis were reviewed as well as their advantages and drawbacks. In addition, we discussed the intrinsic limitations such as the small size or affinity to polystyrene membrane and mention several strategies to overcome these problems. The use of peptides will increase in the coming years and their utility for diagnostic purposes in animals must be evaluated.
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Publication Date: 2022-10-12 PubMed ID: 36288174PubMed Central: PMC9610506DOI: 10.3390/vetsci9100561Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores the use of peptides for diagnosing infectious diseases in animals.

Role of Peptides in Veterinary Diagnosis

  • The key focus of this research review is understanding peptides’ role in veterinary diagnosis. Peptides are short chains of amino acids that can be used in a variety of health applications, including the development of treatments, vaccines, and diagnostic tools.
  • The review includes the application of peptide-based enzyme-linked immunosorbent assay (pELISA), lateral flow devices, and peptide latex agglutination tests. All of these tests are designed to detect several pathogens, including viruses and bacteria that affect domestic animals’ health and productivity.
  • Studies on various animals like cattle, small ruminants, dogs, cats, poultry, horses, and even aquatic organisms have been included. The article presents the results of comparative studies of new peptide-based tests with traditional commercial kits and official tests.

Peptide Synthesis and Its Limitations

  • The review also comments on the methods for producing these peptides. This includes chemical synthesis, recombinant DNA technology, and enzymatic synthesis. Each of these methods has pros and cons, and the choice depends on the specifics of the application.
  • Peptides’ small size and affinity to polystyrene membrane present certain limitations in their use. However, several strategies have been proposed to overcome these issues.

Conclusion and Future Perspectives

  • The use of peptides in veterinary diagnosis is expected to increase in the future. They hold considerable promise due to their good levels of sensitivity and specificity.
  • The potential of peptides has been demonstrated through various studies, and their performance has been appraised through comparisons with commercial kits and official tests. However, their utility for diagnostic purposes in animals needs to be thoroughly evaluated before widespread implementation.

Cite This Article

APA
Aguilar-Montes de Oca S, Montes-de-Oca-Jiménez R, Carlos Vázquez-Chagoyán J, Barbabosa-Pliego A, Eliana Rivadeneira-Barreiro P, C Zambrano-Rodríguez P. (2022). The Use of Peptides in Veterinary Serodiagnosis of Infectious Diseases: A Review. Vet Sci, 9(10), 561. https://doi.org/10.3390/vetsci9100561

Publication

Veterinary sciences
ISSN: 2306-7381
NlmUniqueID: 101680127
Country: Switzerland
Language: English
Volume: 9
Issue: 10
PII: 561

Researcher Affiliations

Aguilar-Montes de Oca, Saúl
  • Centro de Investigación y Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Carretera Toluca-Atlacomulco, Km 15.5, Toluca 50200, CP, Mexico.
Montes-de-Oca-Jiménez, Roberto
  • Centro de Investigación y Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Carretera Toluca-Atlacomulco, Km 15.5, Toluca 50200, CP, Mexico.
Carlos Vázquez-Chagoyán, Juan
  • Centro de Investigación y Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Carretera Toluca-Atlacomulco, Km 15.5, Toluca 50200, CP, Mexico.
Barbabosa-Pliego, Alberto
  • Centro de Investigación y Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Carretera Toluca-Atlacomulco, Km 15.5, Toluca 50200, CP, Mexico.
Eliana Rivadeneira-Barreiro, Pilar
  • Departamento de Veterinaria, Facultad de Ciencias Veterinarias, Universidad Técnica de Manabí, Portoviejo 130105, Ecuador.
C Zambrano-Rodríguez, Pablo
  • Departamento de Veterinaria, Facultad de Ciencias Veterinarias, Universidad Técnica de Manabí, Portoviejo 130105, Ecuador.

Grant Funding

  • 6242/2020CIB / Universidad Autu00f3noma del Estado de Mu00e9xico
  • CAT2021-0184 / Consejo Mexiquense de Ciencia y Tecnologu00eda

Conflict of Interest Statement

The authors declare no conflict of interest.

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