Therapeutic efficacy of undenatured type-II collagen (UC-II) in comparison to glucosamine and chondroitin in arthritic horses.
Abstract: The present investigation evaluated arthritic pain in horses receiving daily placebo, undenatured type II collagen (UC-II) at 320, 480, or 640 mg (providing 80, 120, and 160 mg active UC-II, respectively), and glucosamine and chondroitin (5.4 and 1.8 g, respectively, bid for the first month, and thereafter once daily) for 150 days. Horses were evaluated for overall pain, pain upon limb manipulation, physical examination, and liver and kidney functions. Evaluation of overall pain was based upon a consistent observation of all subjects during a walk and a trot in the same pattern on the same surface. Pain upon limb manipulation was conducted after the walk and trot. It consisted of placing the affected joint in severe flexion for a period of 60 sec. The limb was then placed to the ground and the animal trotted off. The response to the flexion test was then noted with the first couple of strides the animal took. Flexion test was consistent with determining clinically the degree of osteoarthritis in a joint. Horses receiving placebo showed no change in arthritic condition, while those receiving 320 or 480 or 640 mg UC-II exhibited significant reduction in arthritic pain (P < 0.05). UC-II at 480 or 640 mg dose provided equal effects, and therefore, 480 mg dose was considered optimal. With this dose, reduction in overall pain was from 5.7 +/- 0.42 (100%) to 0.7 +/- 0.42 (12%); and in pain upon limb manipulation from 2.35 +/- 0.37 (100%) to 0.52 +/- 0.18 (22%). Although glucosamine and chondroitin treated group showed significant (P < 0.05) reduction in pain compared with pretreated values, the efficacy was less compared with that observed with UC-II. In fact, UC-II at 480 or 640 mg dose was found to be more effective than glucosamine and chondroitin in arthritic horses. Clinical condition (body weight, body temperature, respiration rate, and pulse rate), and liver (bilirubin, GGT, and ALP) and kidney (BUN and creatinine) functions remained unchanged, suggesting that these supplements were well tolerated.
Publication Date: 2010-05-07 PubMed ID: 20444013DOI: 10.1111/j.1365-2885.2009.01079.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This article presents research showing that undenatured type II collagen, or UC-II, was more effective than glucosamine and chondroitin in reducing arthritic pain in horses, with dosages of 480 mg being optimal.
Study Overview
- The research centered around evaluating the efficacy of undenatured type II collagen (UC-II). The researchers compared it to glucosamine and chondroitin, treatments traditionally used to mitigate the effects of arthritis in horses.
- Horses were given daily doses of either a placebo, UC-II (at three different levels: 320 mg, 480 mg, and 640 mg), or a combined dose of glucosamine and chondroitin for 150 days.
- The horses’ responses to these treatments were assessed through measurements of overall pain, pain upon limb manipulation, and via thorough physical examinations. In addition, liver and kidney functions were evaluated to assess tolerance and potential side-effects of the treatments.
Method of Evaluation
- The horses’ overall pain levels were consistently evaluated during their walking and trotting routines. This took place on the same surface to maintain consistency in results.
- A method called “pain upon limb manipulation” was also used. This involves placing the affected joint in a severely flexed position for 60 seconds, and then assessing the animal’s response when it starts to walk or trot again. This method is widely used to clinically determine the degree of osteoarthritis in a joint.
Results
- It was found that 320 mg, 480 mg, or 640 mg doses of UC-II resulted in a significant reduction in arthritic pain amongst horses (P < 0.05), while the placebo group showed no statistical change in condition.
- The 480 mg and 640 mg doses of UC-II were found to achieve relatively equal effects, so researchers designated the 480 mg dosage as the optimal one.
- With the 480 mg dose, overall pain reduction was 88%, and pain upon limb manipulation was reduced by 78% in the horses.
- Additionally, glucosamine and chondroitin treatments did result in a significant reduction in arthritic pain. However, the effectiveness of these treatments paled when compared to that of UC-II at doses of 480 mg or 640 mg.
- Important factors such as body weight, body temperature, respiration rate, and pulse rate, as well as liver and kidney functions, remained constant, suggesting that the horses tolerated the supplements well.
Conclusion
- The research concluded that UC-II is more effective than glucosamine and chondroitin at reducing arthritic pain in horses, making it a superior treatment option.
Cite This Article
APA
Gupta RC, Canerdy TD, Skaggs P, Stocker A, Zyrkowski G, Burke R, Wegford K, Goad JT, Rohde K, Barnett D, DeWees W, Bagchi M, Bagchi D.
(2010).
Therapeutic efficacy of undenatured type-II collagen (UC-II) in comparison to glucosamine and chondroitin in arthritic horses.
J Vet Pharmacol Ther, 32(6), 577-584.
https://doi.org/10.1111/j.1365-2885.2009.01079.x Publication
Researcher Affiliations
- Toxicology Department, Murray State University, Murray/Hopkinsville, KY 42240, USA. ramesh1.gupta@murraystate.edu
MeSH Terms
- Animals
- Chondroitin / administration & dosage
- Chondroitin / therapeutic use
- Collagen Type II / therapeutic use
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Therapy, Combination
- Glucosamine / administration & dosage
- Glucosamine / therapeutic use
- Horse Diseases / drug therapy
- Horses
- Osteoarthritis / drug therapy
- Osteoarthritis / veterinary
- Pain / drug therapy
- Pain / veterinary
Citations
This article has been cited 14 times.- Sahin E, Orhan C, Erten F, Saiyed Z, Azari EK, Durkee S, Sahin K. The effect of oral administration of undenatured type II collagen on monosodium iodoacetate-induced osteoarthritis in young and old rats.. Sci Rep 2023 Apr 20;13(1):6499.
- Zapata A, Fernández-Parra R. Management of Osteoarthritis and Joint Support Using Feed Supplements: A Scoping Review of Undenatured Type II Collagen and Boswellia serrata.. Animals (Basel) 2023 Feb 27;13(5).
- Stabile M, Girelli CR, Lacitignola L, Samarelli R, Crovace A, Fanizzi FP, Staffieri F. (1)H-NMR metabolomic profile of healthy and osteoarthritic canine synovial fluid before and after UC-II supplementation.. Sci Rep 2022 Nov 16;12(1):19716.
- Sifre V, Soler C, Segarra S, Redondo JI, Doménech L, Ten-Esteve A, Vilalta L, Pardo-Marín L, Serra CI. Improved Joint Health Following Oral Administration of Glycosaminoglycans with Native Type II Collagen in a Rabbit Model of Osteoarthritis.. Animals (Basel) 2022 May 30;12(11).
- Mobasheri A, Mahmoudian A, Kalvaityte U, Uzieliene I, Larder CE, Iskandar MM, Kubow S, Hamdan PC, de Almeida CS Jr, Favazzo LJ, van Loon LJC, Emans PJ, Plapler PG, Zuscik MJ. A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis?. Curr Rheumatol Rep 2021 Oct 30;23(11):78.
- Fan R, Hao Y, Liu X, Kang J, Hu J, Mao R, Liu R, Zhu N, Xu M, Li Y. Native Collagen II Relieves Bone Impairment through Improving Inflammation and Oxidative Stress in Ageing db/db Mice.. Molecules 2021 Aug 15;26(16).
- Gencoglu H, Orhan C, Sahin E, Sahin K. Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals.. Animals (Basel) 2020 Apr 17;10(4).
- Stabile M, Samarelli R, Trerotoli P, Fracassi L, Lacitignola L, Crovace A, Staffieri F. Evaluation of the Effects of Undenatured Type II Collagen (UC-II) as Compared to Robenacoxib on the Mobility Impairment Induced by Osteoarthritis in Dogs.. Vet Sci 2019 Sep 4;6(3).
- Dar QA, Schott EM, Catheline SE, Maynard RD, Liu Z, Kamal F, Farnsworth CW, Ketz JP, Mooney RA, Hilton MJ, Jonason JH, Prawitt J, Zuscik MJ. Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis.. PLoS One 2017;12(4):e0174705.
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- Crowley DC, Lau FC, Sharma P, Evans M, Guthrie N, Bagchi M, Bagchi D, Dey DK, Raychaudhuri SP. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial.. Int J Med Sci 2009 Oct 9;6(6):312-21.
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