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Veterinary anaesthesia and analgesia2019; 47(1); 15-27; doi: 10.1016/j.vaa.2019.09.003

Thermal, mechanical and electrical stimuli in antinociceptive studies in standing horses: an update.

Abstract: To perform a literature review of the thermal and mechanical antinociceptive devices used in pharmacological studies in standing horses published after 2011 (2012-2019). To complete a full literature review about electrical stimulation used for evaluation in similar studies. Methods: PubMed, Google Scholar and Web of Science. Conclusions: A high level of standardization has been reached in antinociceptive studies in standing horses using thermal and mechanical stimuli in most recent years. Commercially available testing devices to deliver thermal, mechanical and electrical stimuli, with observation of aversive responses to these stimuli, are reliable, sensitive and specific. For electrical stimulus testing, there is evidence that the resistance between the electrodes should be measured and should not exceed 3 kΩ to guarantee consistent and reproducible stimuli. The specific analysis of electromyographic activity after an electrical stimulus provides more detailed information about the neurons stimulated.
Publication Date: 2019-10-13 PubMed ID: 31813668DOI: 10.1016/j.vaa.2019.09.003Google Scholar: Lookup
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  • Journal Article
  • Review

Summary

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The research article is a comprehensive review on the use of thermal, mechanical, and electrical stimuli in pain-relief studies on standing horses from the years 2012 to 2019. It affirms the growing standardization in these studies and acknowledges the reliability and specificity of commercial testing devices used for this purpose. The paper also suggests that when subjecting horses to electrical stimulus testing, the resistance between the electrodes should not exceed 3 kΩ to ensure consistent and reproducible stimuli.

Objectives and Methodology

  • The article aims to review the use of antinociceptive (pain-reducing) devices that create thermal, mechanical, and electrical stimuli in studies involving standing horses. The time frame for the research reviewed is 2012 to 2019.
  • The researchers rely primarily on scientific literature databases: PubMed, Google Scholar, and Web of Science, to gather data for their review.

Findings & Conclusions

  • The authors indicate that an increased level of standardization has been achieved in recent antinociceptive studies involving standing horses. This standardization has been enabled primarily through the use of thermal and mechanical stimuli.
  • Commercial testing devices that deliver these thermal, mechanical, and electrical stimuli are deemed reliable, sensitive, and specific. This means they provide accurate, sensitive readings and are fit for the intended use.
  • For electrical stimulus testing in particular, the authors draw attention to the importance of maintaining a measured resistance between electrodes, which should not go above 3 kΩ. This is recommended to ensure the consistency and reproducibility of the stimuli.
  • The authors further suggest that a detailed analysis of a horse’s electromyographic activity following an electrical stimulus can provide more in-depth information about the neurons stimulated. Electromyographic activity refers to the electrical signals that muscles generate when they’re activated.

Cite This Article

APA
Gozalo-Marcilla M, Luna SPL, Gasthuys F, Schauvliege S. (2019). Thermal, mechanical and electrical stimuli in antinociceptive studies in standing horses: an update. Vet Anaesth Analg, 47(1), 15-27. https://doi.org/10.1016/j.vaa.2019.09.003

Publication

ISSN: 1467-2995
NlmUniqueID: 100956422
Country: United States
Language: English
Volume: 47
Issue: 1
Pages: 15-27
PII: S1467-2987(19)30294-6

Researcher Affiliations

Gozalo-Marcilla, Miguel
  • The Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Easter Bush Campus, Midlothian, UK. Electronic address: miguelgozalomarcilla@gmail.com.
Luna, Stelio Pacca Loureiro
  • Department of Surgery and Anaesthesiology, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, SP, Brazil.
Gasthuys, Frank
  • Department of Surgery and Anaesthesia of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Schauvliege, Stijn
  • Department of Surgery and Anaesthesia of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

MeSH Terms

  • Analgesics / therapeutic use
  • Animals
  • Electric Stimulation
  • Horses / physiology
  • Hot Temperature
  • Pain Measurement / veterinary
  • Physical Stimulation
  • Standing Position

Citations

This article has been cited 4 times.
  1. Mercer MA, Davis JL, McKenzie HC. The Clinical Pharmacology and Therapeutic Evaluation of Non-Steroidal Anti-Inflammatory Drugs in Adult Horses.. Animals (Basel) 2023 May 10;13(10).
    doi: 10.3390/ani13101597pubmed: 37238029google scholar: lookup
  2. Carvalho JRG, Trindade PHE, Conde G, Antonioli ML, Funnicelli MIG, Dias PP, Canola PA, Chinelatto MA, Ferraz GC. Facial Expressions of Horses Using Weighted Multivariate Statistics for Assessment of Subtle Local Pain Induced by Polylactide-Based Polymers Implanted Subcutaneously.. Animals (Basel) 2022 Sep 13;12(18).
    doi: 10.3390/ani12182400pubmed: 36139260google scholar: lookup
  3. Marzok M, Almubarak AI, Abdel-Raheem SM, El-Khodery S, Shawaf T, Kandeel M. Comparative Study of the Sedative and Anti-nociceptive Effects of Sacrococcygeal Epidural Administration of Romifidine, Lidocaine, and Romifidine/Lidocaine in the Dromedary Camel.. Front Vet Sci 2022;9:891581.
    doi: 10.3389/fvets.2022.891581pubmed: 35832332google scholar: lookup
  4. Hernández-Avalos I, Mota-Rojas D, Mendoza-Flores JE, Casas-Alvarado A, Flores-Padilla K, Miranda-Cortes AE, Torres-Bernal F, Gómez-Prado J, Mora-Medina P. Nociceptive pain and anxiety in equines: Physiological and behavioral alterations.. Vet World 2021 Nov;14(11):2984-2995.