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Home / Equine Research Bank / Vet Med Int / Thromboelastometric profiles of horses affected by exercise-...
Veterinary medicine international2010; 2010; 945789; doi: 10.4061/2010/945789

Thromboelastometric profiles of horses affected by exercise-induced pulmonary hemorrhages.

Abstract: Exercise-induced pulmonary hemorrhage (EIPH) commonly occurs in race horses. Thromboelastometry (TEM) investigates the whole hemostatic process by evaluating the viscoelastic properties of the blood clot from its formation to fibrinolysis. The aim of this study was to assess whether horses with EIPH have abnormal thromboelastometric profiles. Intrinsic and extrinsic pathways, fibrinogen activity and fibrinolysis were investigated by TEM before and after the race in negative controls and in horses on which EIPH was confirmed by bronchoscopy. Compared with controls, horses with EIPH had an increased coagulability in both pre- and postrace samplings, especially for the intrinsic pathway and for the fibinrolytic activity. These results suggest that coagulation is preactivated in horses prone to develop EIPH, possibly due to recent or recurrent hemorrhage.
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Publication Date: 2010-09-30 PubMed ID: 20953331PubMed Central: PMC2952972DOI: 10.4061/2010/945789Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research investigates the relationship between exercise-induced pulmonary hemorrhage (EIPH) in horses and abnormalities in their thromboelastometric profiles. It was found that horses with EIPH had increased coagulability, suggesting that coagulation is preactivated in them, possibly due to recent or recurring hemorrhage.

Research Objectives

  • The research aimed to determine whether horses affected by Exercise-induced pulmonary hemorrhage (EIPH) exhibit abnormal thromboelastometric profiles. Thromboelastometry (TEM) was the method employed in the study to evaluate the viscoelastic properties of the blood clot from its formation to fibrinolysis.

Methodology

  • The study examined both the intrinsic and extrinsic pathways of coagulation, fibrinogen activity, and fibrinolysis using TEM.
  • The sampling was done pre- and post-race on two groups of horses: a control group (horses not affected by EIPH) and horses diagnosed with EIPH based on bronchoscopy.

Findings

  • The results revealed that horses suffering from EIPH demonstrated increased coagulability (enhanced ability to form blood clots) both before and after racing, especially within the intrinsic pathway and fibinrolytic activity compared to the control group.
  • This increased coagulability suggests that coagulation may be preactivated in horses that are susceptible to developing EIPH, potentially as a result of recent or recurrent hemorrhage.

Implications of the Findings

  • The findings provide a novel perspective on the relationship between EIPH and coagulation in horses, possibly indicating a previously unidentified biological mechanism contributing to this condition.
  • Further, this information might aid in predicting the occurrence of EIPH in individual horses, thereby improving preventative measures and treatment approaches in the future.

Cite This Article

APA
Giordano A, Meazza C, Salvadori M, Paltrinieri S. (2010). Thromboelastometric profiles of horses affected by exercise-induced pulmonary hemorrhages. Vet Med Int, 2010, 945789. https://doi.org/10.4061/2010/945789

Publication

Veterinary medicine international
ISSN: 2042-0048
NlmUniqueID: 101524203
Country: United States
Language: English
Volume: 2010
PII: 945789

Researcher Affiliations

Giordano, Alessia
  • Unit of General Pathology and Parasitology, Department of Veterinary Pathology, Hygiene and Public Health, University of Milan, Via Celoria 10, 20133 Milano, Italy.
Meazza, Cecilia
    Salvadori, Marco
      Paltrinieri, Saverio

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        Citations

        This article has been cited 2 times.
        1. Miglio A, Falcinelli E, Mezzasoma AM, Cappelli K, Mecocci S, Gresele P, Antognoni MT. Effect of First Long-Term Training on Whole Blood Count and Blood Clotting Parameters in Thoroughbreds.. Animals (Basel) 2021 Feb 9;11(2).
          doi: 10.3390/ani11020447pubmed: 33572086google scholar: lookup
        2. Poole DC, Erickson HH. Exercise-induced pulmonary hemorrhage: where are we now?. Vet Med (Auckl) 2016;7:133-148.
          doi: 10.2147/VMRR.S120421pubmed: 30050846google scholar: lookup
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