Time-related changes of the cardiovascular system during maintenance anesthesia with sevoflurane and isoflurane in horses.
Abstract: To clarify time-related changes in equine cardiovascular system during maintenance anesthesia (180 min, 1.2 minimum alveolar concentration) with sevoflurane (Sev-group) compared to isoflurane (Iso-group) as the basis for clinical use of Sev, horses were examined for the heart rate (HR), mean arterial pressure (MAP), cardiac index (CI), systemic vascular resistance (SVR) and pre-ejection period (PEP)/ejection time (ET) that is an index of the cardiac contractility. The HR was almost 30 beats/min in both groups without significant temporal change. MAP was significantly elevated with time but there was no significant difference between the groups. In the Sev-group, CI remained unchanged but the significant increase of CI with time was observed in the Iso-group. In the Sev-group SVR was significantly higher than that of the Iso-group and increased with time. No significant difference of PEP/ET was seen between the groups, but PEP/ET lowered with time in the Iso-group in association with prolonged ET. The results indicated that the time-dependent elevation of MAP in the Sev-group reflected increased SVR without increase of CI and that it reflected increased CI resulting from increased stroke volume in the Iso-group in association with lowered PEP/ET, that is, increased cardiac contractility.
Publication Date: 2001-06-20 PubMed ID: 11411498DOI: 10.1292/jvms.63.527Google Scholar: Lookup
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- Comparative Study
- Journal Article
Summary
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The research explores the impact of two anesthetic agents namely, sevoflurane and isoflurane, on the cardiovascular system of horses over time. The study specifically investigates these effects over a 180 minute period under a controlled anesthesia environment.
Methods and Measurements
- The study used two different anesthetics, sevoflurane (Sev-group) and isoflurane (Iso-group), and administered them to horses over a 180 minute period.
- During this time the researchers examined and recorded several cardiovascular parameters including the heart rate (HR), mean arterial pressure (MAP), cardiac index (CI), systemic vascular resistance (SVR) and the pre-ejection period (PEP) relative to ejection time (ET), which is indicative of cardiac contractility.
- The aim was to determine any significant time-related changes in these parameters due to the use of sevoflurane and isoflurane.
Findings
- The heart rate in horses was approximately 30 beats per minute for both the Sev-group and the Iso-group without any notable changes over time.
- However, the mean arterial pressure was found to increase significantly over time, although there was no notable difference between the two groups of horses.
- Cardiac index for the Sev-group remained consistent while the Iso-group showed a significant increase over time.
- The systemic vascular resistance in the Sev-group was significantly higher than in the Iso-group and consistently increased over time.
- No substantial difference was found in PEP/ET ratios between the groups. However, the Iso-group demonstrated a decrease in PEP/ET ratio over time indicating increased cardiac contractility.
Interpretation
- The results suggest that the increase in mean arterial pressure in horses anesthetized with sevoflurane was due to increased systemic vascular resistance without an increase in cardiac index.
- On the other hand, for the Iso-group, the rise in mean arterial pressure was likely a result of an increased cardiac index resulting from an increase in stroke volume.
- Overall, the research provides valuable insights into the time-dependent impact of sevoflurane and isoflurane on the cardiovascular system of horses.
Cite This Article
APA
Yamanaka T, Oku K, Koyama H, Mizuno Y.
(2001).
Time-related changes of the cardiovascular system during maintenance anesthesia with sevoflurane and isoflurane in horses.
J Vet Med Sci, 63(5), 527-532.
https://doi.org/10.1292/jvms.63.527 Publication
Researcher Affiliations
- Racehorse Clinic, Japan Racing Association Miho Training Center, Ibaraki.
MeSH Terms
- Anesthesia, Inhalation / veterinary
- Anesthetics, Inhalation / administration & dosage
- Anesthetics, Inhalation / pharmacology
- Animals
- Blood Pressure / drug effects
- Blood Pressure / physiology
- Cardiovascular System / drug effects
- Echocardiography, Doppler, Pulsed / veterinary
- Heart Rate / drug effects
- Horses / physiology
- Isoflurane / administration & dosage
- Isoflurane / pharmacology
- Male
- Methyl Ethers / administration & dosage
- Methyl Ethers / pharmacology
- Sevoflurane
- Time Factors
Citations
This article has been cited 5 times.- Legler M, Koy L, Kummerfeld N, Fehr M. The influence of anesthesia with isoflurane on the pulmonary and aortic blood flow of Racing Pigeons (Columba livia f. domestica) measured by pulsed wave Doppler echocardiography.. Open Vet J 2019 Apr;9(1):18-26.
- Wakuno A, Maeda T, Kodaira K, Kikuchi T, Ohta M. Anesthetic management with sevoflurane combined with alfaxalone-medetomidine constant rate infusion in a Thoroughbred racehorse undergoing a long-time orthopedic surgery.. J Equine Sci 2017;28(3):111-115.
- Ishizuka T, Tamura J, Nagaro T, Sudo K, Itami T, Umar MA, Miyoshi K, Sano T, Yamashita K. Effects of intermittent positive pressure ventilation on cardiopulmonary function in horses anesthetized with total intravenous anesthesia using combination of medetomidine, lidocaine, butorphanol and propofol (MLBP-TIVA).. J Vet Med Sci 2014 Dec;76(12):1577-82.
- Ohta M, Kurimoto S, Ishikawa Y, Tokushige H, Mae N, Nagata S, Mamada M. Cardiovascular effects of dobutamine and phenylephrine infusion in sevoflurane-anesthetized Thoroughbred horses.. J Vet Med Sci 2013 Nov;75(11):1443-8.
- Sousa MG, Carareto R, De-Nardi AB, Brito FL, Nunes N, Camacho AA. Effects of isoflurane on Tei-index of myocardial performance in healthy dogs.. Can Vet J 2007 Mar;48(3):277-82.
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