Tissue distribution and blood levels of gamma-glutamyl transferase in the horse.

This research study focuses on gamma-glutamyl transferase (GGT), an enzyme that horses mainly produce in the kidneys, liver, and pancreas. The increased level of this enzyme in the blood can indicate liver or pancreas dysfunction.

Study Objective and Methodology

• The study aimed to understand the tissue distribution and impact of GGT in horses. This enzyme is used to measure liver or pancreas dysfunction if high serum enzyme levels are detected.
• GGT was identified mainly in the kidneys, liver, and pancreas of the horse. If renal lesions occur, it can contribute to the urinary release of this enzyme.
• The measurements of GGT can be made from either blood serum or plasma. The study performed its measurements based on 58 horses.

Research Findings

• The research findings indicated that the mean GGT level in the study’s sample of 58 horses was 12 U/L (units per liter).
• These GGT levels remained consistent and were not affected by moderate dilution or minor haemolysis—the breaking down of red blood cells.
• The enzyme activity was minimally decreased by storage at temperatures of -30 degrees Celsius.

Significance and Conclusion

• The study provided valuable insights into the behavior of GGT in horses. It determined that the liver and pancreas are the primary sources of GGT if serum enzyme levels are raised.
• The findings suggest that this enzyme could be a useful measure of liver dysfunction in horses due to its relative hepatic specificity and easy measurement process.