Topical ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% significantly reduce corneal sensitivity without short-term negative side effects in horses.
Abstract: To evaluate corneal sensitivity and acute side effects following application of ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% on the healthy equine cornea. Ropivacaine and lidocaine similarly decreased corneal sensitivity when applied topically without clinically evident short-term ocular side effects. Lidocaine may be preferable in clinical settings due to its large, multi-use vials and similar effects to ropivacaine.
© 2023 American College of Veterinary Ophthalmologists.
Publication Date: 2023-08-07 PubMed ID: 37548143DOI: 10.1111/vop.13137Google Scholar: Lookup
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Summary
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This study aims to understand the effects of two different anesthetic drugs, ropivacaine and lidocaine, when applied to the corneas of horses. Here’s a breakdown:
Objective:
The goal was to evaluate the changes in corneal sensitivity and any immediate side effects after applying 0.5% ropivacaine hydrochloride and 2% lidocaine hydrochloride to the corneas of healthy horses.
Animals studied:
Eight healthy adult horses were used for the study.
Procedure:
- The study design was randomized, masked, and crossover. This means the same horses were tested with both drugs, but the order was randomized and the researchers didn’t know which drug was applied.
- Before applying any medication, baseline measurements were taken. These included SPOT scores (which measure ocular toxicity) and corneal touch thresholds (CTT) using a device called a Cochet-Bonnet esthesiometer.
- A commercially available eyewash was used as a control. One eye of each horse was randomly chosen to receive one of the drugs, while the other eye was treated with the eyewash.
- After application, the CTT was measured at various time intervals up to 75 minutes.
- SPOT scores were again recorded after the trial to check for side effects.
- Statistical analysis was conducted to interpret the data.
Results:
- The CTT for eyes washed with the eyewash was notably different than those treated with either ropivacaine or lidocaine. This indicates both drugs reduced corneal sensitivity.
- There was no significant difference in the CTT between the two drug groups, suggesting they both have a similar numbing effect on the cornea.
- The time taken to reach maximum anesthesia was also similar for both drugs.
- Importantly, there were no side effects observed as per the SPOT scores.
Conclusions:
Both ropivacaine and lidocaine effectively reduced corneal sensitivity when applied topically, and neither showed any immediate adverse effects. Given its packaging and the similar effect to ropivacaine, lidocaine might be the preferred choice in clinical situations.
Cite This Article
APA
Minaldi MP, Fidler LE, Betbeze CM, Wills R, Fontenot RL, Telle MR.
(2023).
Topical ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% significantly reduce corneal sensitivity without short-term negative side effects in horses.
Vet Ophthalmol.
https://doi.org/10.1111/vop.13137 Publication
Researcher Affiliations
- Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA.
- Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA.
- Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA.
- College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA.
- Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA.
- Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA.
Grant Funding
- VAF2022-3 / ACVO Vision for Animals Foundation
- 110000-182500-021000-CVM072 / College of Veterinary Medicine, Mississippi State University
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