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Veterinary research communications1995; 19(3); 179-184; doi: 10.1007/BF01839296

Training-induced modifications in some biochemical defences against free radicals in equine erythrocytes.

Abstract: Oxidative stress develops when the generation of free radicals exceeds the antioxidant capacity of cells or extracellular fluids. It can also occur as a result of physical exercise, and the pathogenesis of exercise-induced myopathies and haemolysis in horses may be related to changes in lipid peroxidation caused by free radicals. Cells have developed biochemical protection against oxidative stress and, as tissues seem to increase their antioxidant defences under chronic activation, training may be one of the ways of increasing antioxidant defences. Accordingly, we tested some enzymatic antioxidant activities as well as nonenzymatic antioxidants in horses undergoing special training. The results indicated a decrease in both chemical and biochemical defences against free radicals during training. It was deduced that the horses' diet may have been unable to provide the increased need for antioxidant defences resulting from training.
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Publication Date: 1995-01-01 PubMed ID: 7571391DOI: 10.1007/BF01839296Google Scholar: Lookup
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  • Journal Article
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores the effects of physical training on certain biochemical protections against free radicals in horse cells, positing that chronic exercise may result in a reduction of these defenses due to an increased need for antioxidants in the animal’s diet.

Understanding Oxidative Stress and Antioxidant Defenses

  • According to the paper, oxidative stress occurs when the body’s production of free radicals — molecules capable of causing cell damage — outpaces the body’s capability to counteract them with antioxidants.
  • Physical exercise can trigger oxidative stress, which in turn may play a role in the development of certain exercise-induced muscle diseases and blood cell destruction in horses. This could be due in part to changes in lipid peroxidation, a harmful process instigated by free radicals.
  • Over time, cells have evolved biochemical defenses to combat oxidative stress, and these defenses potentially increase through chronic activity and demand for antioxidant resources.

Study Design and Results

  • The purpose of this study was to investigate enzymatic antioxidant activities and nonenzymatic antioxidants in horses subjected to special training.
  • Unfortunately, the results did not support the hypothesis that training would increase antioxidant defenses. Instead, both the chemical and biochemical defenses against free radicals decreased in the horses during the training period.

Implication of Findings

  • From these results, the researchers inferred that the diets of the horses involved in the study might have been insufficient to fulfill the increased demand for antioxidant defenses resulting from regular strenuous training.
  • This finding suggests that it may be necessary to reassess and potentially supplement the diets of horses undergoing intensive training, to ensure they are getting enough antioxidants to safeguard against exercise-induced oxidative stress and its deleterious effects.

Cite This Article

APA
Avellini L, Silvestrelli M, Gaiti A. (1995). Training-induced modifications in some biochemical defences against free radicals in equine erythrocytes. Vet Res Commun, 19(3), 179-184. https://doi.org/10.1007/BF01839296

Publication

Veterinary research communications
ISSN: 0165-7380
NlmUniqueID: 8100520
Country: Switzerland
Language: English
Volume: 19
Issue: 3
Pages: 179-184

Researcher Affiliations

Avellini, L
  • Istituto di Biochimica e Chimica Medica, Università di Perugia, Italy.
Silvestrelli, M
    Gaiti, A

      MeSH Terms

      • Analysis of Variance
      • Animal Feed
      • Animal Husbandry
      • Animals
      • Antioxidants / pharmacology
      • Erythrocytes / physiology
      • Free Radicals / blood
      • Glutathione Peroxidase / blood
      • Horses / blood
      • In Vitro Techniques
      • Male
      • Physical Conditioning, Animal / physiology
      • Vitamin E / blood

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      Citations

      This article has been cited 7 times.
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      3. Asala OO, Ayo JO, Rekwot PI, Minka NS, Omoniwa DO, Adenkola AY. Effect of ascorbic acid administration on erythrocyte osmotic fragility of pigs transported by road during the hot-dry season. Vet Res Commun 2011 Apr;35(4):245-54.
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