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Animal reproduction science2012; 134(1-2); 84-94; doi: 10.1016/j.anireprosci.2012.08.015

Transcriptome analyses of bovine, porcine and equine endometrium during the pre-implantation phase.

Abstract: Different reproductive strategies evolved in various mammalian groups to achieve recognition, establishment and maintenance of pregnancy. The complexity of these processes is reflected by a high incidence of embryonic loss during this critical period in many mammalian species. Besides studies in mice and humans a number of transcriptome studies of endometrial tissue samples and also of early embryos have been performed during the pre-implantation phase in cattle, swine and horse to identify genes associated with embryo-maternal interaction. Results of these studies are reviewed and compared between species. The comparison of data sets from different species indicated a general role of interferons for the establishment of pregnancy. In addition to many species-specific changes in gene expression, which may reflect different pregnancy recognition signals and mechanisms of embryo implantation, a number of transcriptome changes were found to be similar across species. These genes may have conserved roles during the establishment of pregnancy in mammals and reflect basic principles of mammalian reproduction. The relevance and strategies, but also the challenges of cross-species comparisons of gene expression data are discussed.
Copyright © 2012 Elsevier B.V. All rights reserved.
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Publication Date: 2012-08-11 PubMed ID: 22917876DOI: 10.1016/j.anireprosci.2012.08.015Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research investigates the differences and similarities in genes of the endometrium in cows, pigs, and horses during the pre-implantation phase of pregnancy, aiming to understand the genetic factors behind the success of pregnancy establishment in these species.

Analyses of Bovine, Porcine and Equine Endometrium

The research utilised transcriptome analyses of endometrial tissue samples collected from cows, pigs, and horses during the early stages of pregnancy, more specifically, during the pre-implantation phase. The

  • The researchers aimed to identify genes associated with interactions between the embryo and the mother.
  • The study performed a review and comparison of results between different mammalian species.

Establishment of Pregnancy

The data from the different species showed general consistency that suggested the essential role of interferons in the establishment of pregnancy.

  • Many changes in gene expression were species-specific, possibly indicating different pregnancy recognition signals and mechanisms of embryo implantation.
  • However, there were also several changes in the transcriptome that were similar across different species.
  • These shared genes likely have conserved roles in establishing pregnancy in mammals, implying the existence of fundamental principles for mammalian reproduction.

Cross-Species Comparisons

The relevance and strategies involved in the cross-species comparison of gene expression data were discussed, as well as the challenges encountered with such an approach.

  • This research shed light on how reproductive strategies have evolved over time in various mammal groups.
  • It also highlighted the percentage of embryonic loss during this critical period, showing the complexity of the processes that lead to successful pregnancy.

Overall, the study provides valuable insights into the genetic factors that contribute to the success of pregnancy establishment in mammals. Such understanding could inform progress in reproductive technologies and treatments for infertility in both animals and humans.

Cite This Article

APA
Bauersachs S, Wolf E. (2012). Transcriptome analyses of bovine, porcine and equine endometrium during the pre-implantation phase. Anim Reprod Sci, 134(1-2), 84-94. https://doi.org/10.1016/j.anireprosci.2012.08.015

Publication

Animal reproduction science
ISSN: 1873-2232
NlmUniqueID: 7807205
Country: Netherlands
Language: English
Volume: 134
Issue: 1-2
Pages: 84-94
PII: S0378-4320(12)00245-X

Researcher Affiliations

Bauersachs, Stefan
  • Molecular Animal Breeding & Biotechnology and Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377 Munich, Germany. bsachs@genzentrum.lmu.de
Wolf, Eckhard

    MeSH Terms

    • Animals
    • Blastocyst / physiology
    • Cattle
    • Embryonic Development / physiology
    • Endometrium / metabolism
    • Female
    • Gene Expression Regulation / physiology
    • Horses
    • Pregnancy
    • Pregnancy, Animal / physiology
    • Swine
    • Transcriptome

    Citations

    This article has been cited 22 times.
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