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Home / Equine Research Bank / Genes Nutr / Transcriptomic profile adaptations following exposure of equ...
Genes & nutrition2016; 11; 5; doi: 10.1186/s12263-016-0523-5

Transcriptomic profile adaptations following exposure of equine satellite cells to nutriactive phytochemical gamma-oryzanol.

Abstract: Adult skeletal muscle myogenesis depends on the activation of satellite cells that have the potential to differentiate into new fibers. Gamma-oryzanol (GO), a commercially available nutriactive phytochemical, has gained global interest on account of its muscle-building and regenerating effects. Here, we investigated GO for its potential influence on myogenesis, using equine satellite cell culture model, since the horse is a unique animal, bred and exercised for competitive sport. To our knowledge, this is the first report where the global gene expression in cultured equine satellite cells has been described. Methods: Equine satellite cells were isolated from semitendinosus muscle and cultured until the second day of differentiation. Differentiating cells were incubated with GO for the next 24 h. Subsequently, total RNA from GO-treated and control cells was isolated, amplified, labeled, and hybridized to two-color Horse Gene Expression Microarray slides. Quantitative PCR was used for the validation of microarray data. Results: Our results revealed 58 genes with changed expression in GO-treated vs. control cells. Analysis of expression changes suggests that various processes are reinforced by GO in differentiating equine satellite cells, including inhibition of myoblast differentiation, increased proliferation and differentiation, stress response, and increased myogenic lineage commitment. Conclusions: The present study may confirm putative muscle-enhancing abilities of GO; however, the collective role of GO in skeletal myogenesis remains equivocal. The diversity of these changes is likely due to heterogenous growth rate of cells in primary culture. Genes identified in our study, modulated by the presence of GO, may become potential targets of future research investigating impact of this supplement in skeletal muscle on proteomic and biochemical level.
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Publication Date: 2016-03-17 PubMed ID: 27482297PubMed Central: PMC4959553DOI: 10.1186/s12263-016-0523-5Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the impact of gamma-oryzanol, a nutriactive phytochemical, on the differentiation of equine satellite cells, which play a crucial role in adult skeletal muscle myogenesis. The study identifies significant changes in the gene expression of these cells when subjected to gamma-oryzanol treatment.

Research Methodology

  • The research began with the isolation of equine satellite cells from the semitendinosus muscle, a part of a horse’s hind limbs. These cells were then grown in a controlled lab setting until they reached the second day of differentiation.
  • On the second day, the cells were treated with gamma-oryzanol and cultured for another 24 hours.
  • After the prescribed time period, total RNA was isolated from both the treated cells and the control group, which were not subjected to gamma-oryzanol.
  • This RNA was then amplified, labeled, and hybridized to two-color Horse Gene Expression Microarray slides to analyze and quantify gene expression in the treated and untreated cells.
  • The data thus obtained from the microarray experiment was further validated using quantitative PCR.

Research Findings

  • The study identified changes in the expression of 58 genes in satellite cells treated with gamma-oryzanol as opposed to their untreated counterparts.
  • Further analysis of these changes revealed that processes, such as inhibition of myoblast differentiation, increased proliferation and differentiation, stress response, and reinforcement of myogenic lineage commitment, were notably influenced by gamma-oryzanol treatment.

Conclusions and Future Research

  • The study recognizes the muscle-enhancing capabilities of gamma-oryzanol, but underlines the need for further research to fully understand the compound’s collective role in skeletal myogenesis.
  • The diversity in the adaptations of the treated equine satellite cells might be due to the heterogeneous growth rate among cells in primary culture.
  • Finally, the researchers suggest that the genes identified as being influenced by gamma-oryzanol could become targets for future study, particularly to investigate the impact of the compound on skeletal muscle at a proteomic and biochemical level.

Cite This Article

APA
Szcześniak KA, Ciecierska A, Ostaszewski P, Sadkowski T. (2016). Transcriptomic profile adaptations following exposure of equine satellite cells to nutriactive phytochemical gamma-oryzanol. Genes Nutr, 11, 5. https://doi.org/10.1186/s12263-016-0523-5

Publication

Genes & nutrition
ISSN: 1555-8932
NlmUniqueID: 101280108
Country: Germany
Language: English
Volume: 11
Pages: 5
PII: 5

Researcher Affiliations

Szcześniak, K A
  • Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.
Ciecierska, A
  • Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.
Ostaszewski, P
  • Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.
Sadkowski, T
  • Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.

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Citations

This article has been cited 7 times.
  1. Ciecierska A, Motyl T, Sadkowski T. Transcriptomic profile of semitendinosus muscle of bulls of different breed and performance.. J Appl Genet 2020 Dec;61(4):581-592.
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  2. Ciecierska A, Motyl T, Sadkowski T. Transcriptomic Profile of Primary Culture of Skeletal Muscle Cells Isolated from Semitendinosus Muscle of Beef and Dairy Bulls.. Int J Mol Sci 2020 Jul 7;21(13).
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