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Genes & nutrition2016; 11; 5; doi: 10.1186/s12263-016-0523-5

Transcriptomic profile adaptations following exposure of equine satellite cells to nutriactive phytochemical gamma-oryzanol.

Abstract: Adult skeletal muscle myogenesis depends on the activation of satellite cells that have the potential to differentiate into new fibers. Gamma-oryzanol (GO), a commercially available nutriactive phytochemical, has gained global interest on account of its muscle-building and regenerating effects. Here, we investigated GO for its potential influence on myogenesis, using equine satellite cell culture model, since the horse is a unique animal, bred and exercised for competitive sport. To our knowledge, this is the first report where the global gene expression in cultured equine satellite cells has been described. Methods: Equine satellite cells were isolated from semitendinosus muscle and cultured until the second day of differentiation. Differentiating cells were incubated with GO for the next 24 h. Subsequently, total RNA from GO-treated and control cells was isolated, amplified, labeled, and hybridized to two-color Horse Gene Expression Microarray slides. Quantitative PCR was used for the validation of microarray data. Results: Our results revealed 58 genes with changed expression in GO-treated vs. control cells. Analysis of expression changes suggests that various processes are reinforced by GO in differentiating equine satellite cells, including inhibition of myoblast differentiation, increased proliferation and differentiation, stress response, and increased myogenic lineage commitment. Conclusions: The present study may confirm putative muscle-enhancing abilities of GO; however, the collective role of GO in skeletal myogenesis remains equivocal. The diversity of these changes is likely due to heterogenous growth rate of cells in primary culture. Genes identified in our study, modulated by the presence of GO, may become potential targets of future research investigating impact of this supplement in skeletal muscle on proteomic and biochemical level.
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Publication Date: 2016-03-17 PubMed ID: 27482297PubMed Central: PMC4959553DOI: 10.1186/s12263-016-0523-5Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the impact of gamma-oryzanol, a nutriactive phytochemical, on the differentiation of equine satellite cells, which play a crucial role in adult skeletal muscle myogenesis. The study identifies significant changes in the gene expression of these cells when subjected to gamma-oryzanol treatment.

Research Methodology

  • The research began with the isolation of equine satellite cells from the semitendinosus muscle, a part of a horse’s hind limbs. These cells were then grown in a controlled lab setting until they reached the second day of differentiation.
  • On the second day, the cells were treated with gamma-oryzanol and cultured for another 24 hours.
  • After the prescribed time period, total RNA was isolated from both the treated cells and the control group, which were not subjected to gamma-oryzanol.
  • This RNA was then amplified, labeled, and hybridized to two-color Horse Gene Expression Microarray slides to analyze and quantify gene expression in the treated and untreated cells.
  • The data thus obtained from the microarray experiment was further validated using quantitative PCR.

Research Findings

  • The study identified changes in the expression of 58 genes in satellite cells treated with gamma-oryzanol as opposed to their untreated counterparts.
  • Further analysis of these changes revealed that processes, such as inhibition of myoblast differentiation, increased proliferation and differentiation, stress response, and reinforcement of myogenic lineage commitment, were notably influenced by gamma-oryzanol treatment.

Conclusions and Future Research

  • The study recognizes the muscle-enhancing capabilities of gamma-oryzanol, but underlines the need for further research to fully understand the compound’s collective role in skeletal myogenesis.
  • The diversity in the adaptations of the treated equine satellite cells might be due to the heterogeneous growth rate among cells in primary culture.
  • Finally, the researchers suggest that the genes identified as being influenced by gamma-oryzanol could become targets for future study, particularly to investigate the impact of the compound on skeletal muscle at a proteomic and biochemical level.

Cite This Article

APA
Szcześniak KA, Ciecierska A, Ostaszewski P, Sadkowski T. (2016). Transcriptomic profile adaptations following exposure of equine satellite cells to nutriactive phytochemical gamma-oryzanol. Genes Nutr, 11, 5. https://doi.org/10.1186/s12263-016-0523-5

Publication

Genes & nutrition
ISSN: 1555-8932
NlmUniqueID: 101280108
Country: Germany
Language: English
Volume: 11
Pages: 5
PII: 5

Researcher Affiliations

Szcześniak, K A
  • Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.
Ciecierska, A
  • Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.
Ostaszewski, P
  • Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.
Sadkowski, T
  • Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.

References

This article includes 70 references
  1. Araya R, Eckardt D, Maxeiner S, Krüger O, Theis M, Willecke K, Sáez JC. Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43.. J Cell Sci 2005 Jan 1;118(Pt 1):27-37.
    doi: 10.1242/jcs.01553pubmed: 15601660google scholar: lookup
  2. Bailey P, Sartorelli V, Hamamori Y, Muscat GE. The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD.. Nucleic Acids Res 1998 Dec 1;26(23):5501-10.
    doi: 10.1093/nar/26.23.5501pmc: PMC147985pubmed: 9826778google scholar: lookup
  3. Balogh S, Naus CC, Merrifield PA. Expression of gap junctions in cultured rat L6 cells during myogenesis.. Dev Biol 1993 Feb;155(2):351-60.
    doi: 10.1006/dbio.1993.1034pubmed: 8381751google scholar: lookup
  4. Bentzinger CF, Wang YX, Rudnicki MA. Building muscle: molecular regulation of myogenesis.. Cold Spring Harb Perspect Biol 2012 Feb 1;4(2).
    doi: 10.1101/cshperspect.a008342pmc: PMC3281568pubmed: 22300977google scholar: lookup
  5. Brancaccio M, Guazzone S, Menini N, Sibona E, Hirsch E, De Andrea M, Rocchi M, Altruda F, Tarone G, Silengo L. Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain.. J Biol Chem 1999 Oct 8;274(41):29282-8.
    doi: 10.1074/jbc.274.41.29282pubmed: 10506186google scholar: lookup
  6. Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC, Gaasterland T, Glenisson P, Holstege FC, Kim IF, Markowitz V, Matese JC, Parkinson H, Robinson A, Sarkans U, Schulze-Kremer S, Stewart J, Taylor R, Vilo J, Vingron M. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.. Nat Genet 2001 Dec;29(4):365-71.
    doi: 10.1038/ng1201-365pubmed: 11726920google scholar: lookup
  7. Brown AE, Palsgaard J, Borup R, Avery P, Gunn DA, De Meyts P, Yeaman SJ, Walker M. p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients.. Am J Physiol Endocrinol Metab 2015 Jan 1;308(1):E63-70.
    doi: 10.1152/ajpendo.00115.2014pmc: PMC4281683pubmed: 25370850google scholar: lookup
  8. Brown D, Hikim AP, Kovacheva EL, Sinha-Hikim I. Mouse model of testosterone-induced muscle fiber hypertrophy: involvement of p38 mitogen-activated protein kinase-mediated Notch signaling.. J Endocrinol 2009 Apr;201(1):129-39.
    doi: 10.1677/JOE-08-0476pmc: PMC4732720pubmed: 19144735google scholar: lookup
  9. Busson M, Carazo A, Seyer P, Grandemange S, Casas F, Pessemesse L, Rouault JP, Wrutniak-Cabello C, Cabello G. Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation.. Oncogene 2005 Mar 3;24(10):1698-710.
    doi: 10.1038/sj.onc.1208373pubmed: 15674337google scholar: lookup
  10. Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, Vandesompele J, Wittwer CT. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments.. Clin Chem 2009 Apr;55(4):611-22.
    doi: 10.1373/clinchem.2008.112797pubmed: 19246619google scholar: lookup
  11. Chevrel G, Hohlfeld R, Sendtner M. The role of neurotrophins in muscle under physiological and pathological conditions.. Muscle Nerve 2006 Apr;33(4):462-76.
    doi: 10.1002/mus.20444pubmed: 16228973google scholar: lookup
  12. Cicero AF, Gaddi A. Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions.. Phytother Res 2001 Jun;15(4):277-89.
    doi: 10.1002/ptr.907pubmed: 11406848google scholar: lookup
  13. Clow C, Jasmin BJ. Brain-derived neurotrophic factor regulates satellite cell differentiation and skeltal muscle regeneration.. Mol Biol Cell 2010 Jul 1;21(13):2182-90.
    doi: 10.1091/mbc.E10-02-0154pmc: PMC2893983pubmed: 20427568google scholar: lookup
  14. DeChiara TM, Bowen DC, Valenzuela DM, Simmons MV, Poueymirou WT, Thomas S, Kinetz E, Compton DL, Rojas E, Park JS, Smith C, DiStefano PS, Glass DJ, Burden SJ, Yancopoulos GD. The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo.. Cell 1996 May 17;85(4):501-12.
    doi: 10.1016/S0092-8674(00)81251-9pubmed: 8653786google scholar: lookup
  15. Dobrzyn A, Ntambi JM. The role of stearoyl-CoA desaturase in the control of metabolism.. Prostaglandins Leukot Essent Fatty Acids 2005 Jul;73(1):35-41.
    pubmed: 15941655doi: 10.1016/j.plefa.2005.04.011google scholar: lookup
  16. Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.. Nucleic Acids Res 2002 Jan 1;30(1):207-10.
    doi: 10.1093/nar/30.1.207pmc: PMC99122pubmed: 11752295google scholar: lookup
  17. Eslami S, Esa NM, Marandi SM, Ghasemi G, Eslami S. Effects of gamma oryzanol supplementation on anthropometric measurements & muscular strength in healthy males following chronic resistance training.. Indian J Med Res 2014 Jun;139(6):857-63.
    pmc: PMC4164998pubmed: 25109720
  18. Fernyhough ME, Helterline DL, Vierck JL, Dodson MV, Bucci LR, Feliciano JEFF. Myogenic satellite cell proliferative and differentiative responses to components of common oral ergogenic supplements.. Res Sports Med 2004;12(3):161–190.
    doi: 10.1080/15438620490497323google scholar: lookup
  19. Fry AC, Bonner E, Lewis DL, Johnson RL, Stone MH, Kraemer WJ. The effects of gamma-oryzanol supplementation during resistance exercise training.. Int J Sport Nutr 1997 Dec;7(4):318-29.
    pubmed: 9407258doi: 10.1123/ijsn.7.4.318google scholar: lookup
  20. Gopal-Srivastava R, Haynes JI 2nd, Piatigorsky J. Regulation of the murine alpha B-crystallin/small heat shock protein gene in cardiac muscle.. Mol Cell Biol 1995 Dec;15(12):7081-90.
    doi: 10.1128/MCB.15.12.7081pmc: PMC230963pubmed: 8524275google scholar: lookup
  21. Gorbe A, Krenacs T, Cook JE, Becker DL. Myoblast proliferation and syncytial fusion both depend on connexin43 function in transfected skeletal muscle primary cultures.. Exp Cell Res 2007 Apr 1;313(6):1135-48.
    doi: 10.1016/j.yexcr.2007.01.012pubmed: 17331498google scholar: lookup
  22. Greene EA, Raub RH. Procedures for harvesting satellite cells from equine skeletal muscle.. J Equine Vet Sci 1992;12(1):33–35.
    doi: 10.1016/S0737-0806(06)81383-3google scholar: lookup
  23. Gu J, Orr N, Park SD, Katz LM, Sulimova G, MacHugh DE, Hill EW. A genome scan for positive selection in thoroughbred horses.. PLoS One 2009 Jun 2;4(6):e5767.
    doi: 10.1371/journal.pone.0005767pmc: PMC2685479pubmed: 19503617google scholar: lookup
  24. Haddad F, Adams GR. Inhibition of MAP/ERK kinase prevents IGF-I-induced hypertrophy in rat muscles.. J Appl Physiol (1985) 2004 Jan;96(1):203-10.
    doi: 10.1152/japplphysiol.00856.2003pubmed: 12959952google scholar: lookup
  25. Hansen A. Myostatin mRNA expression in cultured equine satellite cells.. .
  26. Harris PA, Harris RC. Ergogenic potential of nutritional strategies and substances in the horse.. Livest Prod Sci 2005;92(2):147–165.
    doi: 10.1016/j.livprodsci.2004.11.016google scholar: lookup
  27. Hong M, Schachter K, Jiang G, Krauss R. Neogenin regulates Shh pathway activity during digit patterning.. Dev Biol 2011;356(1):147.
    doi: 10.1016/j.ydbio.2011.05.159google scholar: lookup
  28. Huang CCJ. Potential functionality and digestibility of oryzanol as determined using in vitro cell culture models.. Doctoral dissertation, Louisiana State University. 2003.
  29. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.. Nat Protoc 2009;4(1):44-57.
    pubmed: 19131956doi: 10.1038/nprot.2008.211google scholar: lookup
  30. Ismail M, Al-Naqeeb G, Mamat WA, Ahmad Z. Gamma-oryzanol rich fraction regulates the expression of antioxidant and oxidative stress related genes in stressed rat's liver.. Nutr Metab (Lond) 2010 Mar 24;7:23.
    pmc: PMC2859356pubmed: 20331906doi: 10.1186/1743-7075-7-23google scholar: lookup
  31. Ismail N, Ismail M, Imam MU, Azmi NH, Fathy SF, Foo JB, Abu Bakar MF. Mechanistic basis for protection of differentiated SH-SY5Y cells by oryzanol-rich fraction against hydrogen peroxide-induced neurotoxicity.. BMC Complement Altern Med 2014 Dec 5;14:467.
    doi: 10.1186/1472-6882-14-467pmc: PMC4528700pubmed: 25475556google scholar: lookup
  32. Jank M, Zwierzchowski L, Siadkowska E, Budasz-Świderska M, Sadkowski T, Oprządek J. Polymorphism in the 5’flanking region of the myostatin gene affects myostatin and TGF-β.. J Anim Feed Sci 2006;15:381–391.
  33. Kamradt MC, Chen F, Sam S, Cryns VL. The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation.. J Biol Chem 2002 Oct 11;277(41):38731-6.
    doi: 10.1074/jbc.M201770200pubmed: 12140279google scholar: lookup
  34. Keren A, Tamir Y, Bengal E. The p38 MAPK signaling pathway: a major regulator of skeletal muscle development.. Mol Cell Endocrinol 2006 Jun 27;252(1-2):224-30.
    doi: 10.1016/j.mce.2006.03.017pubmed: 16644098google scholar: lookup
  35. Kollias HD, McDermott JC. Transforming growth factor-beta and myostatin signaling in skeletal muscle.. J Appl Physiol (1985) 2008 Mar;104(3):579-87.
    doi: 10.1152/japplphysiol.01091.2007pubmed: 18032576google scholar: lookup
  36. Lamon S, Wallace MA, Léger B, Russell AP. Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophy.. J Physiol 2009 Apr 15;587(Pt 8):1795-803.
    doi: 10.1113/jphysiol.2009.168674pmc: PMC2683965pubmed: 19255118google scholar: lookup
  37. Lee A, Hakuno F, Northcott P, Pessin JE, Rozakis Adcock M. Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells.. PLoS One 2013;8(1):e55634.
    doi: 10.1371/journal.pone.0055634pmc: PMC3559603pubmed: 23383252google scholar: lookup
  38. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.. Methods 2001 Dec;25(4):402-8.
    doi: 10.1006/meth.2001.1262pubmed: 11846609google scholar: lookup
  39. Ma L, Lin J, Qiao Y, Weng W, Liu W, Wang J, Sun F. Serum CD166: a novel hepatocellular carcinoma tumor marker.. Clin Chim Acta 2015 Feb 20;441:156-62.
    doi: 10.1016/j.cca.2014.12.034pubmed: 25562819google scholar: lookup
  40. MAURO A. Satellite cell of skeletal muscle fibers.. J Biophys Biochem Cytol 1961 Feb;9(2):493-5.
    doi: 10.1083/jcb.9.2.493pmc: PMC2225012pubmed: 13768451google scholar: lookup
  41. de Mello F, Streit DP Jr, Sabin N, Gabillard JC. Dynamic expression of tgf-β2, tgf-β3 and inhibin βA during muscle growth resumption and satellite cell differentiation in rainbow trout (Oncorhynchus mykiss).. Gen Comp Endocrinol 2015 Jan 1;210:23-9.
    doi: 10.1016/j.ygcen.2014.10.011pubmed: 25449661google scholar: lookup
  42. Miwa T, Manabe Y, Kurokawa K, Kamada S, Kanda N, Bruns G, Ueyama H, Kakunaga T. Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes.. Mol Cell Biol 1991 Jun;11(6):3296-306.
    doi: 10.1128/MCB.11.6.3296pmc: PMC360182pubmed: 1710027google scholar: lookup
  43. Mok GF, Sweetman D. Many routes to the same destination: lessons from skeletal muscle development.. Reproduction 2011 Mar;141(3):301-12.
    doi: 10.1530/REP-10-0394pubmed: 21183656google scholar: lookup
  44. Mösseler A, Licht S, Wilhelm L, Kamphues J, Ellis AD. Can oral intake of gamma-oryzanol (experimentally given orally as pure substance) result in doping relevant testosterone levels in the urine of mares and geldings?. The Impact of Nutrition on the Health and Welfare of Horses Wageningen Academic Publishers. 2010;128;293-296.
  45. Mousavi K, Jasmin BJ. BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation.. J Neurosci 2006 May 24;26(21):5739-49.
    doi: 10.1523/JNEUROSCI.5398-05.2006pmc: PMC6675269pubmed: 16723531google scholar: lookup
  46. Muscat GE, Rea S, Downes M. Identification of a regulatory function for an orphan receptor in muscle: COUP-TF II affects the expression of the myoD gene family during myogenesis.. Nucleic Acids Res 1995 Apr 25;23(8):1311-8.
    doi: 10.1093/nar/23.8.1311pmc: PMC306855pubmed: 7753622google scholar: lookup
  47. Nelissen JM, Torensma R, Pluyter M, Adema GJ, Raymakers RA, van Kooyk Y, Figdor CG. Molecular analysis of the hematopoiesis supporting osteoblastic cell line U2-OS.. Exp Hematol 2000 Apr;28(4):422-32.
    doi: 10.1016/S0301-472X(00)00127-2pubmed: 10781900google scholar: lookup
  48. Ohara K, Uchida A, Nagasaka R, Ushio H, Ohshima T. The effects of hydroxycinnamic acid derivatives on adiponectin secretion.. Phytomedicine 2009 Mar;16(2-3):130-7.
    doi: 10.1016/j.phymed.2008.09.012pubmed: 19013780google scholar: lookup
  49. Ostaszewski P, Kowalska A, Szarska E, Szpotański P, Cywinska A, Bałasińska B. Effects of β-hydroxy-β-methylbutyrate and γ-oryzanol on blood biochemical markers in exercising thoroughbred race horses.. J Equine Vet Sci 2012;32(9):542–551.
    doi: 10.1016/j.jevs.2012.01.002google scholar: lookup
  50. Powell DJ, McFarland DC, Cowieson AJ, Muir WI, Velleman SG. The effect of nutritional status and muscle fiber type on myogenic satellite cell fate and apoptosis.. Poult Sci 2014 Jan;93(1):163-73.
    doi: 10.3382/ps.2013-03450pubmed: 24570436google scholar: lookup
  51. Ramery E, Closset R, Art T, Bureau F, Lekeux P. Expression microarrays in equine sciences.. Vet Immunol Immunopathol 2009 Feb 15;127(3-4):197-202.
    doi: 10.1016/j.vetimm.2008.10.314pubmed: 19027176google scholar: lookup
  52. Rodier A, Marchal-Victorion S, Rochard P, Casas F, Cassar-Malek I, Rouault JP, Magaud JP, Mason DY, Wrutniak C, Cabello G. BTG1: a triiodothyronine target involved in the myogenic influence of the hormone.. Exp Cell Res 1999 Jun 15;249(2):337-48.
    doi: 10.1006/excr.1999.4486pubmed: 10366433google scholar: lookup
  53. Rom O, Kaisari S, Reznick AZ, Aizenbud D. Peroxynitrite induces degradation of myosin heavy chain via p38 MAPK and muscle-specific E3 ubiquitin ligases in C2 skeletal myotubes.. Adv Exp Med Biol 2015;832:1-8.
    pubmed: 25315626doi: 10.1007/5584_2014_9google scholar: lookup
  54. Rouault JP, Rimokh R, Tessa C, Paranhos G, Ffrench M, Duret L, Garoccio M, Germain D, Samarut J, Magaud JP. BTG1, a member of a new family of antiproliferative genes.. EMBO J 1992 Apr;11(4):1663-70.
    pmc: PMC556617pubmed: 1373383doi: 10.1002/j.1460-2075.1992.tb05213.xgoogle scholar: lookup
  55. Rudnicki MA, Schnegelsberg PN, Stead RH, Braun T, Arnold HH, Jaenisch R. MyoD or Myf-5 is required for the formation of skeletal muscle.. Cell 1993 Dec 31;75(7):1351-9.
    doi: 10.1016/0092-8674(93)90621-Vpubmed: 8269513google scholar: lookup
  56. Sadkowski T, Jank M, Zwierzchowski L, Oprzadek J, Motyl T. Comparison of skeletal muscle transcriptional profiles in dairy and beef breeds bulls.. J Appl Genet 2009;50(2):109-23.
    doi: 10.1007/BF03195662pubmed: 19433908google scholar: lookup
  57. Sadkowski T, Jank M, Zwierzchowski L, Siadkowska E, Oprzadek J, Motyl T. Gene expression profiling in skeletal muscle of Holstein-Friesian bulls with single-nucleotide polymorphism in the myostatin gene 5'-flanking region.. J Appl Genet 2008;49(3):237-50.
    doi: 10.1007/BF03195620pubmed: 18670060google scholar: lookup
  58. Schabort EJ, van der Merwe M, Loos B, Moore FP, Niesler CU. TGF-beta's delay skeletal muscle progenitor cell differentiation in an isoform-independent manner.. Exp Cell Res 2009 Feb 1;315(3):373-84.
    doi: 10.1016/j.yexcr.2008.10.037pubmed: 19038250google scholar: lookup
  59. Singh BN, Rao KS, Rao ChM. Ubiquitin-proteasome-mediated degradation and synthesis of MyoD is modulated by alphaB-crystallin, a small heat shock protein, during muscle differentiation.. Biochim Biophys Acta 2010 Feb;1803(2):288-99.
    doi: 10.1016/j.bbamcr.2009.11.009pubmed: 20005263google scholar: lookup
  60. Suleiman MS, Singh RJ, Stewart CE. Apoptosis and the cardiac action of insulin-like growth factor I.. Pharmacol Ther 2007 Jun;114(3):278-94.
    doi: 10.1016/j.pharmthera.2007.03.001pubmed: 17499363google scholar: lookup
  61. Swart GW. Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell migration.. Eur J Cell Biol 2002 Jun;81(6):313-21.
    doi: 10.1078/0171-9335-00256pubmed: 12113472google scholar: lookup
  62. Szcześniak KA, Ostaszewski P, Fuller JC Jr, Ciecierska A, Sadkowski T. Dietary supplementation of β-hydroxy-β-methylbutyrate in animals - a review.. J Anim Physiol Anim Nutr (Berl) 2015 Jun;99(3):405-17.
    doi: 10.1111/jpn.12234pubmed: 25099672google scholar: lookup
  63. Szcześniak KA, Ostaszewski P, Ciecierska A, Sadkowski T. Investigation of nutriactive phytochemical - gamma-oryzanol in experimental animal models.. J Anim Physiol Anim Nutr (Berl) 2016 Aug;100(4):601-17.
    pubmed: 26718022doi: 10.1111/jpn.12428google scholar: lookup
  64. Tao Y, Neppl RL, Huang ZP, Chen J, Tang RH, Cao R, Zhang Y, Jin SW, Wang DZ. The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly.. J Cell Biol 2011 Aug 22;194(4):551-65.
    doi: 10.1083/jcb.201010090pmc: PMC3160588pubmed: 21859860google scholar: lookup
  65. Tonami K, Hata S, Ojima K, Ono Y, Kurihara Y, Amano T, Sato T, Kawamura Y, Kurihara H, Sorimachi H. Calpain-6 deficiency promotes skeletal muscle development and regeneration.. PLoS Genet 2013;9(8):e1003668.
    doi: 10.1371/journal.pgen.1003668pmc: PMC3731218pubmed: 23935533google scholar: lookup
  66. Trendelenburg AU, Meyer A, Jacobi C, Feige JN, Glass DJ. TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A.. Skelet Muscle 2012 Feb 7;2(1):3.
    doi: 10.1186/2044-5040-2-3pmc: PMC3295657pubmed: 22313861google scholar: lookup
  67. Wicik Z, Sadkowski T, Jank M, Motyl T. The transcriptomic signature of myostatin inhibitory influence on the differentiation of mouse C2C12 myoblasts.. Pol J Vet Sci 2011;14(4):643-52.
    pubmed: 22439337doi: 10.2478/v10181-011-0095-7google scholar: lookup
  68. Xie X, Qin J, Lin SH, Tsai SY, Tsai MJ. Nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) modulates mesenchymal cell commitment and differentiation.. Proc Natl Acad Sci U S A 2011 Sep 6;108(36):14843-8.
    doi: 10.1073/pnas.1110236108pmc: PMC3169151pubmed: 21873211google scholar: lookup
  69. Xie X, Tang K, Yu CT, Tsai SY, Tsai MJ. Regulatory potential of COUP-TFs in development: stem/progenitor cells.. Semin Cell Dev Biol 2013 Dec;24(10-12):687-93.
    doi: 10.1016/j.semcdb.2013.08.005pmc: PMC3849206pubmed: 23978678google scholar: lookup
  70. Zhang L, Wang XH, Wang H, Du J, Mitch WE. Satellite cell dysfunction and impaired IGF-1 signaling cause CKD-induced muscle atrophy.. J Am Soc Nephrol 2010 Mar;21(3):419-27.
    doi: 10.1681/ASN.2009060571pmc: PMC2831855pubmed: 20056750google scholar: lookup

Citations

This article has been cited 7 times.
  1. Ciecierska A, Motyl T, Sadkowski T. Transcriptomic profile of semitendinosus muscle of bulls of different breed and performance. J Appl Genet 2020 Dec;61(4):581-592.
    doi: 10.1007/s13353-020-00577-1pubmed: 32851594google scholar: lookup
  2. Ciecierska A, Motyl T, Sadkowski T. Transcriptomic Profile of Primary Culture of Skeletal Muscle Cells Isolated from Semitendinosus Muscle of Beef and Dairy Bulls. Int J Mol Sci 2020 Jul 7;21(13).
    doi: 10.3390/ijms21134794pubmed: 32645861google scholar: lookup
  3. Chodkowska KA, Ciecierska A, Majchrzak K, Ostaszewski P, Sadkowski T. Simultaneous miRNA and mRNA Transcriptome Profiling of Differentiating Equine Satellite Cells Treated with Gamma-Oryzanol and Exposed to Hydrogen Peroxide. Nutrients 2018 Dec 2;10(12).
    doi: 10.3390/nဒ1871pubmed: 30513813google scholar: lookup
  4. Lee S, Kim MB, Kim C, Hwang JK. Whole grain cereal attenuates obesity-induced muscle atrophy by activating the PI3K/Akt pathway in obese C57BL/6N mice. Food Sci Biotechnol 2018 Feb;27(1):159-168.
    doi: 10.1007/s10068-017-0277-xpubmed: 30263736google scholar: lookup
  5. Chodkowska KA, Ciecierska A, Majchrzak K, Ostaszewski P, Sadkowski T. Effect of β-hydroxy-β-methylbutyrate on miRNA expression in differentiating equine satellite cells exposed to hydrogen peroxide. Genes Nutr 2018;13:10.
    doi: 10.1186/s12263-018-0598-2pubmed: 29662554google scholar: lookup
  6. Sadkowski T, Ciecierska A, Oprządek J, Balcerek E. Breed-dependent microRNA expression in the primary culture of skeletal muscle cells subjected to myogenic differentiation. BMC Genomics 2018 Jan 31;19(1):109.
    doi: 10.1186/s12864-018-4492-5pubmed: 29390965google scholar: lookup
  7. Szcześniak KA, Ciecierska A, Ostaszewski P, Sadkowski T. Characterisation of equine satellite cell transcriptomic profile response to β-hydroxy-β-methylbutyrate (HMB). Br J Nutr 2016 Oct;116(8):1315-1325.
    doi: 10.1017/S000711451600324Xpubmed: 27691998google scholar: lookup
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