Transendoscopic electrocautery-induced gastric ulcers as a model for gastric healing studies in ponies.
Abstract: The ponies were apparently healthy and 6-20 months of age. In Study 1, gastric lesions were created by transendoscopic electrocautery in the non-glandular gastric mucosa, adjacent to the margo plicatus in 9 ponies which were then treated with water, 12 mg cimetidine HCl/kg bwt or 18 mg cimetidine HCl/kg bwt per os every 12 h for 35 days. In Study 2, gastric lesions were similarly induced in 9 ponies in the non-glandular mucosa and also in the glandular mucosa just below the non-glandular lesion on the greater curvature of the stomach. The ponies were treated with water, 8 mg cimetidine/kg bwt or 16 mg cimetidine/kg bwt per os every 8 h for 21 days. In both studies gastric lesion healing was monitored twice weekly by video gastroscopy. There was no apparent difference in healing times between the water and cimetidine treatment groups in either study. These results indicate that uniform gastric ulcers can be created by transendoscopic electrocautery in the non-glandular mucosa of ponies and that these ulcers heal at a predictable rate which should be useful in studying compounds that might accelerate healing of gastric mucosal lesions. However, cimetidine was not effective in accelerating the rate of healing under the conditions of this study.
Publication Date: 1994-03-01 PubMed ID: 8575368DOI: 10.1111/j.2042-3306.1994.tb04344.xGoogle Scholar: Lookup
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research investigates induced gastric ulcers in ponies as a potential model for studying gastric healing. The results show that consistent ulcers can be created and tend to heal at a predictable rate, which could offer a useful method for studying treatments aimed at accelerating healing. However, it was found that the drug cimetidine was not effective in speeding up this healing process.
Research Design and Methodology
- The study was conducted on seemingly healthy ponies aged between 6 and 20 months.
- Two separate studies were conducted. In the first, gastric lesions were created with transendoscopic electrocautery in the non-glandular gastric mucosa of nine ponies. These were then treated either with water or with one of two dosages of cimetidine hydrochloride every 12 hours for 35 days.
- In the second study, similar gastric lesions were induced in another group of nine ponies both in the non-glandular mucosa and in the glandular mucosa. These ponies were then treated either with water or with one of two dosages of cimetidine every eight hours for 21 days.
- A video gastroscope monitored healing of the induced gastric lesions twice a week in both studies.
Research Findings
- The studies found that healing times for the created gastric lesions showed no significant differences between ponies treated with water and those treated with cimetidine.
- The researchers were able to successfully and consistently induce ulcers by using transendoscopic electrocautery in the non-glandular mucosa of the ponies. These ulcers healed at a consistent and predictable rate.
Applicability of Findings
- In terms of its applicability to aid future research, this finding suggests that similar methods could be reliably employed to study compounds that might hasten the healing of gastric lesions.
- However, the study discovered that, under the circumstances of these specific experiments, cimetidine—an antacid used to treat and prevent ulcers—did not prove effective in accelerating the rate of healing.
Cite This Article
APA
MacAllister CG, Lowrey F, Stebbins M, Newman MS, Young B.
(1994).
Transendoscopic electrocautery-induced gastric ulcers as a model for gastric healing studies in ponies.
Equine Vet J, 26(2), 100-103.
https://doi.org/10.1111/j.2042-3306.1994.tb04344.x Publication
Researcher Affiliations
- Department of Medicine and Surgery, Oklahoma State University, Stillwater 74078, USA.
MeSH Terms
- Administration, Oral
- Animals
- Anti-Ulcer Agents / administration & dosage
- Anti-Ulcer Agents / therapeutic use
- Cimetidine / administration & dosage
- Cimetidine / therapeutic use
- Disease Models, Animal
- Electrocoagulation / adverse effects
- Electrocoagulation / veterinary
- Endoscopy, Digestive System / veterinary
- Female
- Gastric Mucosa / drug effects
- Gastric Mucosa / injuries
- Gastric Mucosa / physiology
- Horse Diseases / drug therapy
- Horse Diseases / etiology
- Horse Diseases / physiopathology
- Horses
- Male
- Stomach Ulcer / drug therapy
- Stomach Ulcer / etiology
- Stomach Ulcer / physiopathology
- Stomach Ulcer / veterinary
- Wound Healing / physiology
Citations
This article has been cited 1 times.- Doucet MY, Vrins AA, Dionne R, Alva R, Ericsson G. Efficacy of a paste formulation of omeprazole for the treatment of naturally occurring gastric ulcers in training standardbred racehorses in Canada. Can Vet J 2003 Jul;44(7):581-5.
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