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Home / Equine Research Bank / Can Vet J / Transient Fanconi syndrome in Quarter horses.
The Canadian veterinary journal = La revue veterinaire canadienne2014; 55(2); 147-151;

Transient Fanconi syndrome in Quarter horses.

Abstract: Two Quarter horses with weight loss had glucosuria, euglycemia, and a mild metabolic acidosis suggesting a proximal renal tubular defect. Further testing revealed transient generalized aminoaciduria, lactic aciduria, and glucosuria, indicating Fanconi syndrome. Both horses recovered with supportive therapy. This is the first report of acquired Fanconi syndrome in horses. Deux chevaux Quarter horse ayant subi une perte de poids étaient atteints de glucosurie, d’euglycémie et d’une acidose métabolique légère suggérant un défaut tubulaire rénal proximal. De nouveaux tests ont révélé une amino-acidurie, une acidurie lactique et une euglycémie généralisée transitoire, indicatif du syndrome de Fanconi. Les deux chevaux se sont rétablis avec une thérapie de soutien. Il s’agit du premier rapport du syndrome de Fanconi acquis chez les chevaux.(Traduit par Isabelle Vallières).
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Publication Date: 2014-02-04 PubMed ID: 24489393PubMed Central: PMC3894872
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research describes the first documented cases of acquired Fanconi syndrome, a kidney disorder, in Quarter horses. The disorder was transient and the horses recovered after receiving supportive therapy.

Background of the Research

  • The research focuses on two Quarter horses that had experienced weight loss and undergone extensive medical tests.
  • The initial symptoms suggested a problem with their kidneys, specifically a defect in their proximal renal tubules – a part of the kidney essential for the absorption and secretion of various molecules.
  • More extensive tests revealed that the horses had temporary generalised aminoaciduria, glucosuria and lactic aciduria, conditions associated with Fanconi syndrome.

Fanconi Syndrome

  • Fanconi syndrome is a condition that affects the kidney’s ability to absorb and process certain molecules and ions. This can lead to abnormal excretion of glucose, amino acids, bicarbonate ions, water, and other substances in the urine. The condition can be either genetic or acquired through exposure to certain toxins, drugs, or diseases.
  • In this study, the horses exhibited symptoms typical of Fanconi syndrome – glucosuria, aminoaciduria, and lactic aciduria. Glucosuria refers to glucose in the urine, aminoaciduria involves amino acids being present in the urine and lactic aciduria indicates lactic acid in the urine.

Findings and Recovery

  • The study found that the two Quarter horses had an acquired form of Fanconi syndrome, not a genetic form.
  • The syndrome was transient, meaning that it was temporary. The horses’ conditions improved with the help of supportive therapy.
  • This study is significant because it’s the first time that Fanconi syndrome has been documented to occur in horses. This addition to medical literature can aid future diagnosis and treatment of this syndrome in equine patients.

Cite This Article

APA
Ohmes CM, Davis EG, Beard LA, Vander Werf KA, Bianco AW, Giger U. (2014). Transient Fanconi syndrome in Quarter horses. Can Vet J, 55(2), 147-151.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 55
Issue: 2
Pages: 147-151

Researcher Affiliations

Ohmes, Cameon M
  • Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, Kansas 66502, USA (Ohmes, Davis, Beard); Department of Clinical Sciences, College of Veterinary Medicine, University of Illinois, 1008 West Hazelwood Drive, Champaign, Illinois 61802, USA (Vander Werf); Department of Clinical Sciences, College of Veterinary Medicine, Purdue University, Lynn Hall, 625 Harrison Street, West Lafayette, Indiana 47907, USA (Bianco); Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104, USA (Giger).
Davis, Elizabeth G
  • Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, Kansas 66502, USA (Ohmes, Davis, Beard); Department of Clinical Sciences, College of Veterinary Medicine, University of Illinois, 1008 West Hazelwood Drive, Champaign, Illinois 61802, USA (Vander Werf); Department of Clinical Sciences, College of Veterinary Medicine, Purdue University, Lynn Hall, 625 Harrison Street, West Lafayette, Indiana 47907, USA (Bianco); Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104, USA (Giger).
Beard, Laurie A
  • Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, Kansas 66502, USA (Ohmes, Davis, Beard); Department of Clinical Sciences, College of Veterinary Medicine, University of Illinois, 1008 West Hazelwood Drive, Champaign, Illinois 61802, USA (Vander Werf); Department of Clinical Sciences, College of Veterinary Medicine, Purdue University, Lynn Hall, 625 Harrison Street, West Lafayette, Indiana 47907, USA (Bianco); Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104, USA (Giger).
Vander Werf, Karie A
  • Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, Kansas 66502, USA (Ohmes, Davis, Beard); Department of Clinical Sciences, College of Veterinary Medicine, University of Illinois, 1008 West Hazelwood Drive, Champaign, Illinois 61802, USA (Vander Werf); Department of Clinical Sciences, College of Veterinary Medicine, Purdue University, Lynn Hall, 625 Harrison Street, West Lafayette, Indiana 47907, USA (Bianco); Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104, USA (Giger).
Bianco, Alex W
  • Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, Kansas 66502, USA (Ohmes, Davis, Beard); Department of Clinical Sciences, College of Veterinary Medicine, University of Illinois, 1008 West Hazelwood Drive, Champaign, Illinois 61802, USA (Vander Werf); Department of Clinical Sciences, College of Veterinary Medicine, Purdue University, Lynn Hall, 625 Harrison Street, West Lafayette, Indiana 47907, USA (Bianco); Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104, USA (Giger).
Giger, Urs
  • Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, Kansas 66502, USA (Ohmes, Davis, Beard); Department of Clinical Sciences, College of Veterinary Medicine, University of Illinois, 1008 West Hazelwood Drive, Champaign, Illinois 61802, USA (Vander Werf); Department of Clinical Sciences, College of Veterinary Medicine, Purdue University, Lynn Hall, 625 Harrison Street, West Lafayette, Indiana 47907, USA (Bianco); Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104, USA (Giger).

MeSH Terms

  • Animals
  • Fanconi Syndrome / veterinary
  • Female
  • Horse Diseases / diagnosis
  • Horse Diseases / pathology
  • Horses
  • Male
  • Time Factors

Grant Funding

  • P40 OD010939 / NIH HHS
  • P40 RR002512 / NCRR NIH HHS
  • OD012095 / NIH HHS
  • RR002152 / NCRR NIH HHS

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Citations

This article has been cited 2 times.
  1. Cesbron N, Dorso L, Royer AL, Dervilly-Pinel G, Hervé J. Aminoaciduria Caused by Fanconi Syndrome in a Heifer. J Vet Intern Med 2017 Mar;31(2):598-603.
    doi: 10.1111/jvim.14605pubmed: 28109116google scholar: lookup
  2. van Galen G, Divers TJ, Savage V, Schott HC 2nd, Siwinska N. ECEIM consensus statement on equine kidney disease. J Vet Intern Med 2024 Jul-Aug;38(4):2008-2025.
    doi: 10.1111/jvim.17101pubmed: 38801172google scholar: lookup
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