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Home / Equine Research Bank / Front Vet Sci / Treatment of experimental hyperchloremic metabolic acidosis ...
Frontiers in veterinary science2024; 11; 1376578; doi: 10.3389/fvets.2024.1376578

Treatment of experimental hyperchloremic metabolic acidosis in horses with enteral electrolyte solution containing sodium acetate.

Abstract: In adult horses, the development and evaluation of enteral electrolyte solutions containing sodium acetate for correcting hyperchloremic metabolic acidosis are still lacking, although these electrolyte and acid-base imbalances are commonly observed. The objective of this study was to evaluate the alkalinizing effect of two enteral electrolyte solutions containing different concentrations of acetate, administered via nasogastric tube in continuous flow, in adult horses with experimental hyperchloremic metabolic acidosis. Unassigned: Six mares aged between 3 and 10 years were used in a 6×2 crossover design, with each animal receiving both treatments. The horses were subjected to a protocol to induce hyperchloremic metabolic acidosis. They then received one of two treatments: HighAcetate (81.4 mmol/L) and LowAcetate (22.7 mmol/L) at an infusion rate of 15 mL/kg/h for 12 h. Plasma, serum, and urinary biochemical assessments; hematocrit; urinary volume, pH, and specific gravity; and blood gas analysis were measured at the following time points: T-12 h (beginning of the 12-h fast), T0h (end of fasting and beginning of the acidosis induction phase), every 2 h during the hyperchloremic metabolic acidosis induction phase (T2h and T4h), every 2 h during the 12-h enteral hydration phase (T2h, T4h, Tt6h, T8h, T10h, and T12h), with one sample taken at T24h (24 h after the start of acidosis induction) and another at T36h (36 h after the start of acidosis induction). Data were analyzed using descriptive statistics and analysis of variance based on a factorial design of repeated measures, with Tukey's test or the Kruskal-Wallis test with Dunn's test for non-parametric tests. Unassigned: At the end of the induction phase, the animals developed moderate to severe hyperchloremic metabolic acidosis. The HighAcetate solution effectively corrected electrolyte and acid-base imbalances before the end of the treatment phase (Tt12h), while the LowAcetate solution was not effective in correcting those changes. Unassigned: The HighAcetate (81.4 mmol/L) solution is deemed an effective and safe alternative for the treatment of hyperchloremic metabolic acidosis in horses.
Copyright © 2024 Monteiro, Costa, Ermita, Júnior, Mattos, Mansur, dos Santos, Alves, Mafort, Fidélis, Avanza, Teixeira, Viana and Filho.
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Publication Date: 2024-09-11 PubMed ID: 39323875PubMed Central: PMC11422386DOI: 10.3389/fvets.2024.1376578Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research is about the treatment of hyperchloremic metabolic acidosis in horses using sodium acetate. The study suggests that using a high concentration of Sodium Acetate is an effective treatment for such condition in horses.

Introduction and Objective of the Study

  • The research focuses on the evaluation of sodium acetate in enteral electrolyte solutions for its ability to correct hyperchloremic metabolic acidosis in horses. Hyperchloremic metabolic acidosis is a common acid-base imbalance in horses which hasn’t been adequately addressed.
  • The researchers have experimented with two electrolyte solutions containing different concentrations of acetate in an attempt to discern their alkalinizing effect in the course of the disorder. The solutions were administered to adult horses suffering from the induced disorder through nasogastric tubes, in continuous flow.

Methodology

  • Six mares aged from 3 to 10 years were used in the study. The sample selection followed a 6×2 crossover design, which allowed each horse to receive both treatments for a comprehensive evaluation.
  • The horses underwent a protocol to induce hyperchloremic metabolic acidosis. Post-induction, they received one of two treatments: HighAcetate (81.4 mmol/L) and LowAcetate (22.7 mmol/L). The infusion rate was set to 15 ml/kg/hr for a period of 12 hours.
  • Several measurements and assessments were conducted pre and post-infusion, including plasma, serum, and urinary biochemical assessments, hematocrit, urinary volume, pH, specific gravity, and blood gas analysis.

Data Analysis

  • For analyzing the collected data, they employed descriptive statistics and analysis of variance based on a factorial design of repeated measures, accompanied by Tukey’s test or the Kruskal-Wallis test with Dunn’s test for non-parametric tests.

Results

  • The research showed that, post the induction phase, the horses developed moderate to severe hyperchloremic metabolic acidosis.
  • It was observed that the HighAcetate solution was effective in correcting the electrolyte and acid-base imbalances before the end of the treatment phase. In contrast, the LowAcetate solution didn’t show effective results in counteracting the changes.

Conclusion

  • The study concluded that the HighAcetate solution containing 81.4 mmol/L of acetate is an efficient and safe alternative for treating hyperchloremic metabolic acidosis in horses.

Cite This Article

APA
Monteiro LC, Costa CM, Ermita PAN, Júnior SJPG, Mattos FS, Mansur FC, Dos Santos MO, Alves SR, Mafort EG, Fidélis CF, Avanza MFB, Teixeira RBC, Viana RB, Filho JDR. (2024). Treatment of experimental hyperchloremic metabolic acidosis in horses with enteral electrolyte solution containing sodium acetate. Front Vet Sci, 11, 1376578. https://doi.org/10.3389/fvets.2024.1376578

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 11
Pages: 1376578
PII: 1376578

Researcher Affiliations

Monteiro, Lorena Chaves
  • Laborary of Research in Veterinary Internal Medicine, Veterinary Department, Universidade Federal de Viçosa, Viçosa, Brazil.
Costa, Caio Monteiro
  • Laborary of Research in Veterinary Internal Medicine, Veterinary Department, Universidade Federal de Viçosa, Viçosa, Brazil.
Ermita, Pedro Ancelmo Nunes
  • Universidade Federal do Sul e Sudeste do Pará, Xinguara, Brazil.
Júnior, Silvio José Printes Gomes
  • Laborary of Research in Veterinary Internal Medicine, Veterinary Department, Universidade Federal de Viçosa, Viçosa, Brazil.
Mattos, Felipe Sperandio
  • Laborary of Research in Veterinary Internal Medicine, Veterinary Department, Universidade Federal de Viçosa, Viçosa, Brazil.
Mansur, Fernanda Campos
  • Laborary of Research in Veterinary Internal Medicine, Veterinary Department, Universidade Federal de Viçosa, Viçosa, Brazil.
Dos Santos, Mayara Oliveira
  • Laborary of Research in Veterinary Internal Medicine, Veterinary Department, Universidade Federal de Viçosa, Viçosa, Brazil.
Alves, Samuel Rodrigues
  • Laborary of Research in Veterinary Internal Medicine, Veterinary Department, Universidade Federal de Viçosa, Viçosa, Brazil.
Mafort, Erica Garcia
  • Laborary of Research in Veterinary Internal Medicine, Veterinary Department, Universidade Federal de Viçosa, Viçosa, Brazil.
Fidélis, Cíntia Fernandes
  • Laborary of Research in Veterinary Internal Medicine, Veterinary Department, Universidade Federal de Viçosa, Viçosa, Brazil.
Avanza, Marcel Ferreira Bastos
  • Laborary of Research in Veterinary Internal Medicine, Veterinary Department, Universidade Federal de Viçosa, Viçosa, Brazil.
Teixeira, Raffaella Bertoni Cavalvanti
  • Laborary of Research in Veterinary Internal Medicine, Veterinary Department, Universidade Federal de Viçosa, Viçosa, Brazil.
Viana, Rinaldo Batista
  • Institute of Animal Health and Production, Universidade Federal Rural da Amazônia, Belém, Brazil.
Filho, José Dantas Ribeiro
  • Laborary of Research in Veterinary Internal Medicine, Veterinary Department, Universidade Federal de Viçosa, Viçosa, Brazil.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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