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Treatment of persistent mating-induced endometritis in mares with the non-steroid anti-inflammatory drug vedaprofen.
Abstract: Recently, successful treatment of mares with a history of persistent mating-induced endometritis (PMIE) with dexamethasone has been reported. As systemic treatment of horses with glucocorticoids should be handled with caution, we tested the hypothesis that treatment with the non-steroid anti-inflammatory drug (NSAID) vedaprofen, an inhibitor of cyclooxygenase-2, may have comparative, positive effects on fertility. Barren mares with a history of repeated PMIE were treated with vedaprofen (n = 8; initially 2 mg/kg bodyweight followed by 1 mg/kg orally twice daily) from 1 day before the first insemination to 1 day after ovulation or left untreated (n = 9). All mares received oxytocin (20 I.E. s.c.) thrice daily. Uterine swabs were collected for bacteriology and cytology. The day after ovulation, fluid accumulation was detected in three control mares and four treated mares (n.s.). The percentage of neutrophils in uterine cytology was significantly increased in comparison to the day before ovulation irrespective of treatment. Pregnancy was confirmed in two of nine mares in the control group and seven of eight mares in the treatment group (p < 0.05). NSAIDs may positively affect fertility in mares with a history of PMIE.
Publication Date: 2010-01-16 PubMed ID: 20074320DOI: 10.1111/j.1439-0531.2009.01572.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Controlled Clinical Trial
- Journal Article
Summary
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The research explores possible treatment for mares that suffer from persistent mating-induced endometritis. They examined the potential benefits of utilizing the non-steroid anti-inflammatory drug vedaprofen in lieu of dexamethasone, to improve fertility. The study found that vedaprofen helped establish pregnancy more effectively than no treatment.
Experiment Design
- The researchers sought to test whether a non-steroid anti-inflammatory drug (NSAID) called vedaprofen could effectively treat mares with persistent mating-induced endometritis (PMIE).
- They selected two groups: one group of mares treated with vedaprofen (n=8) and a control group that received no treatment (n=9).
- Both groups received oxytocin thrice daily. The vedaprofen group was given an initial dose of 2 mg/kg bodyweight, followed by 1 mg/kg orally twice daily, starting from a day prior to the first artificial insemination and lasting until a day after ovulation.
- Uterine swabs were collected for bacteriological and cytological analysis.
Findings and Analysis
- Post-ovulation, fluid accumulation was noted in the uterus of three control mares and four treated mares, indicating no significant difference caused by the treatment.
- Upon cytological examination, there was a significant increase in neutrophils (white blood cells indicative of an inflammatory response) in both groups after ovulation, irrespective of the treatment.
- When examined for pregnancy, two out of the nine mares from the control group were found to be pregnant, while seven out of the eight treated mares were pregnant. This difference was statistically significant, showing a positive impact of vedaprofen on fertility.
Conclusion
- The hypothesis of the study was confirmed: vedaprofen, a non-steroid anti-inflammatory drug, can potentially be an effective treatment to improve the fertility of mares with a history of persistent mating-induced endometritis.
- Despite there being no significant reduction in inflammation noted in the mares treated with vedaprofen, the considerably higher pregnancy rate suggests a link between vedaprofen administration and enhanced fertility.
Cite This Article
APA
Rojer H, Aurich C.
(2010).
Treatment of persistent mating-induced endometritis in mares with the non-steroid anti-inflammatory drug vedaprofen.
Reprod Domest Anim, 45(6), e458-e460.
https://doi.org/10.1111/j.1439-0531.2009.01572.x Publication
Researcher Affiliations
- Centre for Artificial Insemination and Embryo Transfer, University for Veterinary Sciences, Vienna, Austria.
MeSH Terms
- Animals
- Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
- Copulation
- Endometritis / drug therapy
- Endometritis / veterinary
- Female
- Horse Diseases / drug therapy
- Horses
- Naphthalenes / therapeutic use
- Pregnancy
- Propionates / therapeutic use
Citations
This article has been cited 6 times.- Yáñez Ramil U, Jezierska S, Krupa M, Bogado Pascottini O. Fundamentals of microbiome-based therapies for reproductive tract inflammatory diseases in domestic animals. Anim Reprod 2025;22(3):e20250030.
- Wang Z, Zeng S, Wang Y, Wang T, Qu H, Zhu Y, Li J. Reproductive Disorders in Donkeys: Current Evidence and Update. Animals (Basel) 2024 Aug 28;14(17).
- Dawod A, Miro J, Elbaz HT, Fahmy H, Abdoon AS. Effect of Intrauterine Infusion of Equine Fresh Platelets-Rich Plasma (PRP) or Lyophilized PRP (L-GF(equina)) on Ovarian Activity and Pregnancy Rate in Repeat Breeder Purebred Arabian Mares. Animals (Basel) 2021 Apr 14;11(4).
- Köhne M, Kuhlmann M, Tönißen A, Martinsson G, Sieme H. Diagnostic and Treatment Practices of Equine Endometritis-A Questionnaire. Front Vet Sci 2020;7:547.
- Canisso IF, Segabinazzi LGTM, Fedorka CE. Persistent Breeding-Induced Endometritis in Mares - a Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology. Int J Mol Sci 2020 Feb 20;21(4).
- Fantoni DT, Ida KK, de Almeida TI, Ambrósio AM. A comparison of pre and post-operative vedaprofen with ketoprofen for pain control in dogs. BMC Vet Res 2015 Feb 7;11:24.
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