Treatment of respiratory infections in horses with ceftiofur sodium.
Abstract: Ceftiofur sodium was evaluated as a therapy for respiratory infections in horses. This cephalosporin antimicrobial was administered intramuscularly every 24 h and at a dose of 2.2 mg/kg (1.0 mg/lb) of body weight. The efficacy of ceftiofur sodium was compared with that of a positive control drug, ampicillin sodium (recommended dose of 6.6 mg/kg [3 mg/lb], given every 12 h). Both treatments were continued for 48 h after clinical symptoms were no longer evident (maximum of 10 days). Fifty-five (55) horses with naturally acquired respiratory infections were included in the study; 28 were treated with ceftiofur and 27 with ampicillin. Clinical improvement was recorded for 92.9% of the patients treated with ceftiofur and 92.6% of the animals receiving ampicillin. Both therapies reduced body temperatures to an afebrile level after 2 days of treatment. Complete recovery/cure was noted for 78.6% of the ceftiofur patients and 59.3% of the horses treated with ampicillin. Supporting variables (depression/malaise, respiration/dyspnoea, nasal discharge) were assessed and these also substantiated the effectiveness of the treatments. Both antibiotics were well tolerated. Neither pain nor swelling were noted at the ceftiofur injection site(s). None of the animals developed diarrhoea. Data from this study indicated that ceftiofur sodium is an effective and safe treatment for respiratory infections in horses.
Publication Date: 1992-07-01 PubMed ID: 1499539DOI: 10.1111/j.2042-3306.1992.tb02840.xGoogle Scholar: Lookup
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- Clinical Trial
- Journal Article
- Randomized Controlled Trial
Summary
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This research assessed the effectiveness of the drug ceftiofur sodium, an antibiotic, in treating respiratory infections in horses. The study demonstrated that ceftiofur sodium had substantial efficacy for treatment, comparable to the commonly used antibiotic, ampicillin sodium.
Research Methodology
- The study involved 55 horses with naturally acquired respiratory infections. 28 were treated with ceftiofur sodium and 27 with ampicillin sodium.
- The ceftiofur sodium was given at a dosage of 2.2 mg/kg of body weight, administered every 24 hours. Ampicillin sodium was used as a positive control drug given at a dose of 6.6 mg/kg, every 12 hours.
- Treatment was continued in these horses for 48 hours after their clinical symptoms ceased to be visible, up to a maximum period of 10 days.
- The efficacy was tracked by observing clinical improvements in the horses, complete recoveries were recorded and other variables such as depression/malaise, respiration/dyspnea, and nasal discharge were assessed.
Research Findings
- Clinical improvement was observed in 92.9% of the horses treated with ceftiofur sodium and 92.6% of the horses treated with ampicillin sodium.
- Body temperatures of the horses returned to normal after two days of treatment with either antibiotic.
- A complete recovery was observed in 78.6% of the horses treated with ceftiofur sodium and 59.3% of the horses treated with ampicillin sodium
Implications of the Study
- The study concludes that ceftiofur sodium is an effective therapy for respiratory infections in horses.
- Furthermore, it demonstrated a comparable level of effectiveness with the conventionally used antibiotic, ampicillin sodium.
- Both antibiotics were well tolerated by the horses, with no side effects such as pain, swelling, or diarrhea observed.
- This research supports the use of ceftiofur sodium as a safe and effective treatment for naturally acquired respiratory infections in horses.
Cite This Article
APA
Folz SD, Hanson BJ, Griffin AK, Dinvald LL, Swerczek TW, Walker RD, Foreman JH.
(1992).
Treatment of respiratory infections in horses with ceftiofur sodium.
Equine Vet J, 24(4), 300-304.
https://doi.org/10.1111/j.2042-3306.1992.tb02840.x Publication
Researcher Affiliations
- Department of Clinical Research/Product Development, Upjohn Company, Kalamazoo, Michigan 49001.
MeSH Terms
- Ampicillin / therapeutic use
- Animals
- Body Temperature
- Cephalosporins / administration & dosage
- Cephalosporins / therapeutic use
- Depression
- Female
- Horse Diseases / drug therapy
- Horses
- Injections, Intramuscular / veterinary
- Male
- Nasal Mucosa / metabolism
- Respiration
- Respiratory Tract Infections / drug therapy
- Respiratory Tract Infections / veterinary
Citations
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