Treatments of the injured tendon in Veterinary Medicine: from scaffolds to adult stem cells.
Abstract: In order to treat frequently occurring conditions such as traumatic rupture or over-strain tendinopathies, the techniques of tissue engineering and cell-based therapies have become an accepted modus operandi since other available remedies appear to be ineffective in restoring the original structure and function of the injured tissue. However, the mechanisms accounting for the effectiveness of novel regenerative approaches in treating equine tendon and ligament injuries remain poorly characterised. In this review we summarize and discuss the most significant results of our research regarding bioscaffold technology for treating complete tendon tears and the use of adult stem cells for treating tendon lesions induced by over-strain.
Publication Date: 2013-11-08 PubMed ID: 24203578DOI: 10.14670/HH-29.10.417Google Scholar: Lookup
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- Journal Article
- Review
Summary
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The research article discusses the use of tissue engineering and cell-based therapies, focusing on bioscaffold technology and adult stem cell treatment, for healing tendons and ligaments in horses that have been injured due to trauma or overuse.
Tissue Engineering and Cell-based Therapies
- The research highlights that conventional treatments have proven insufficient in fully restoring the anatomy and function of injured tendons in the veterinary field, particularly in horses, and hence necessitate novel approaches.
- This paper presents tissue engineering and cell-based therapies as a suitable alternative. These techniques are gaining recognition as effective methods to treat traumatic ruptures and tendinopathies resulting from over-straining.
- The researchers, however, note the need for further understanding of the underlying mechanisms that make these regenerative approaches effective.
Bioscaffold Technology
- The article discusses in detail the use of bioscaffold technology in the treatment of complete tendon tears.
- Bioscaffold technology involves the use of a fabricated, biocompatible structure that can be implanted into a living organism to replace or support damaged biological tissue.
- This technology provides a physical scaffold that facilitates the regrowth and development of new healthy tissue in the location of the injured tendon.
Adult Stem Cells Treatment
- Apart from bioscaffold technology, the researchers have also explored the use of adult stem cells to treat tendon lesions caused by over-strain.
- Unlike embryonic stem cells, adult stem cells can be extracted from the patient, multiplied in a lab and then re-implanted back into the patient. This method eliminates the risk of a potential immune rejection.
- The ability of adult stem cells to differentiate into various specialized cell types makes them a potentially effective treatment for damaged or injured tissue.
Key Takeaways
- The research highlights the potential of tissue engineering and cell-based therapies in treating tendon and ligament injuries in equines, specifically using bioscaffold technology and adult stem cell treatment.
- The authors emphasise the need for more research to fully understand the mechanisms behind the effectiveness of these treatment strategies.
Cite This Article
APA
Patruno M, Martinello T.
(2013).
Treatments of the injured tendon in Veterinary Medicine: from scaffolds to adult stem cells.
Histol Histopathol, 29(4), 417-422.
https://doi.org/10.14670/HH-29.10.417 Publication
Researcher Affiliations
- Department of Comparative Biomedicine and Food Science, Università di Padova, Agripolis, Legnaro (PD), Italy. marco.pat@unipd.it.
- Department of Comparative Biomedicine and Food Science, Università di Padova, Agripolis, Legnaro (PD), Italy.
MeSH Terms
- Adult Stem Cells
- Animals
- Mesenchymal Stem Cell Transplantation / methods
- Tendon Injuries / therapy
- Tendon Injuries / veterinary
- Tissue Engineering / methods
- Tissue Engineering / trends
- Tissue Scaffolds
Citations
This article has been cited 5 times.- Randelli F, Sartori P, Carlomagno C, Bedoni M, Menon A, Vezzoli E, Sommariva M, Gagliano N. The Collagen-Based Medical Device MD-Tissue Acts as a Mechanical Scaffold Influencing Morpho-Functional Properties of Cultured Human Tenocytes. Cells 2020 Dec 8;9(12).
- Ribitsch I, Gueltekin S, Keith MF, Minichmair K, Peham C, Jenner F, Egerbacher M. Age-related changes of tendon fibril micro-morphology and gene expression. J Anat 2020 Apr;236(4):688-700.
- Brandt L, Schubert S, Scheibe P, Brehm W, Franzen J, Gross C, Burk J. Tenogenic Properties of Mesenchymal Progenitor Cells Are Compromised in an Inflammatory Environment. Int J Mol Sci 2018 Aug 28;19(9).
- Gomiero C, Bertolutti G, Martinello T, Van Bruaene N, Broeckx SY, Patruno M, Spaas JH. Tenogenic induction of equine mesenchymal stem cells by means of growth factors and low-level laser technology. Vet Res Commun 2016 Mar;40(1):39-48.
- Cuervo B, Rubio M, Sopena J, Dominguez JM, Vilar J, Morales M, Cugat R, Carrillo JM. Hip osteoarthritis in dogs: a randomized study using mesenchymal stem cells from adipose tissue and plasma rich in growth factors. Int J Mol Sci 2014 Jul 31;15(8):13437-60.
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