Triphasic nephroblastoma in a horse.
Abstract: A large abdominal mass in a 3-year-old filly was discovered clinically and removed and examined after the horse had been humanely killed. Histologically, three different tissue types were noted, occurring in equal amounts: epithelium largely in the form of well-differentiated tubules, multifocally distributed cell-dense foci of blastema, and myxoid to fibrous stroma. A diagnosis of triphasic nephroblastoma, a rare tumour in the horse, was made on the basis of microscopical findings. The finding of numerous glomeruloid structures confirmed the diagnosis and assisted in distinguishing the tumour from a teratoma. The histogenesis of nephroblastoma is briefly discussed in the context of the histological and immunohistochemical findings of the case.
Publication Date: 1996-02-01 PubMed ID: 8920219DOI: 10.1016/s0021-9975(96)80008-9Google Scholar: Lookup
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Summary
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This research paper discusses a rare case of triphasic nephroblastoma, a kind of tumor, in a young horse. The study explores the diagnostic approach and the histogenesis of this condition.
Objective of the Research
The research aims to scrutinize a specific case of triphasic nephroblastoma in a horse. The study attempts to illustrate the diagnosing process of this rare condition and engage in a brief exploration of the tumor’s histogenesis – the process through which the tumor develops.
Case Overview
- A large abdominal mass was detected in a 3-year-old filly, leading to clinical examination and later euthanasia of the young horse.
- The mass was carefully examined post-mortem to reveal histologically three different tissue types — epithelium, blastema, and stroma.
- Each tissue type was found in identical amounts, and this triphasic presence led to the diagnosis of nephroblastoma, a rarely observed tumor in equines.
Diagnostics and Findings
- Microscopic findings formed the foundation for the diagnosis.
- Confirming the diagnosis were numerous glomeruloid structures, a distinctive characteristic feature of this kind of tumor.
- This confirmation also helped differentiate the condition from teratoma, another category of tumor which might display similar characteristics.
Discussion on Histogenesis
- The paper takes a close look at the process of histogenesis, meaning the formation and development of the tissues in the tumor.
- The discussion relies on the distinct histological and immunohistochemical findings unveiled in the case.
- This segment uncovers insights into the development and progression of this specific type of tumor.
Cite This Article
APA
Jardine JE, Nesbit JW.
(1996).
Triphasic nephroblastoma in a horse.
J Comp Pathol, 114(2), 193-198.
https://doi.org/10.1016/s0021-9975(96)80008-9 Publication
Researcher Affiliations
- Department of Pathology, University of Pretoria, Onderstepoort, South Africa.
MeSH Terms
- Abdominal Neoplasms / pathology
- Abdominal Neoplasms / veterinary
- Animals
- Female
- Horse Diseases / pathology
- Horses
- Wilms Tumor / pathology
- Wilms Tumor / veterinary
Citations
This article has been cited 2 times.- Castiglioni V, De Maglie M, Queliti R, Rustighi A, Del Sal G, Radaelli E. Immunohistochemical Characterization of a Renal Nephroblastoma in a Trp53-mutant and Prolyl Isomerase 1-deficient Mouse. J Toxicol Pathol 2013 Dec;26(4):423-7.
- Romero A, Rodgerson DH, Fontaine GL. Hand-assisted laparoscopic removal of a nephroblastoma in a horse. Can Vet J 2010 Jun;51(6):637-9.
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