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Home / Equine Research Bank / Vet Pathol / Two hundred three cases of equine lymphoma classified accord...
Veterinary pathology2012; 50(1); 86-93; doi: 10.1177/0300985812451603

Two hundred three cases of equine lymphoma classified according to the World Health Organization (WHO) classification criteria.

Abstract: Lymphoma is the most common malignant neoplasm in the horse. Single case reports and small retrospective studies of equine lymphomas are reported infrequently in the literature. A wide range of clinical presentations, tumor subtypes, and outcomes have been described, and the diversity of the results demonstrates the need to better define lymphomas in horses. As part of an initiative of the Veterinary Cooperative Oncology Group, 203 cases of equine lymphoma have been gathered from 8 institutions. Hematoxylin and eosin slides from each case were reviewed and 187 cases were immunophenotyped and categorized according to the World Health Organization classification system. Data regarding signalment, clinical presentation, and tumor topography were also examined. Ages ranged from 2 months to 31 years (mean, 10.7 years). Twenty-four breeds were represented; Quarterhorses were the most common breed (n = 55), followed by Thoroughbreds (n = 33) and Standardbreds (n = 30). Lymphomas were categorized into 13 anatomic sites. Multicentric lymphomas were common (n = 83), as were skin (n = 38) and gastrointestinal tract (n = 24). A total of 14 lymphoma subtypes were identified. T-cell-rich large B-cell lymphomas were the most common subtype, diagnosed in 87 horses. Peripheral T-cell lymphomas (n = 45) and diffuse large B-cell lymphomas (n = 26) were also frequently diagnosed.
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Publication Date: 2012-06-13 PubMed ID: 22700849DOI: 10.1177/0300985812451603Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research examines and classifies 203 cases of lymphoma in horses, a common malignant cancer, in line with the standards of the World Health Organization. The study looks at multiple factors, including breed, age, and anatomical location, highlighting the prevalence of specific types of lymphoma and advocating for a better understanding of the disease in horses.

Research Methodology

  • The research involved the review of 203 cases of equine lymphoma, obtained from eight different institutions.
  • Training slides stained with hematoxylin and eosin, a common procedure in studying cancerous tissue, were reviewed in these cases.
  • Out of these, 187 cases were further analysed for their immune characteristics, also known as immunophenotypyping, and classified according to the World Health Organization classification system.
  • Other information studied included signalment (age, breed, and sex), clinical presentation, and tumor topography or location.

Findings

  • The horses under study ranged from 2 months to 31 years in age, with an average age of 10.7 years.
  • Twenty-four different breeds were part of the study. Quarter horses constituted the largest group, with 55 horses, followed by Thoroughbreds and Standardbreds.
  • Thirteen different anatomic sites for lymphoma were identified. Common locations for the lymphomas were multiple sites on the body (multicentric, n=83), skin (n=38), and the gastrointestinal tract (n=24).
  • Fourteen different subtypes of lymphoma were identified. The most commonly diagnosed lymphoma subtype was a T-cell-rich large B-cell lymphoma seen in 87 horses. Other common lymphomas were peripheral T-cell lymphomas and diffuse large B-cell lymphomas.

Implication of Findings

  • The wide range and diversity of clinical presentations, tumor subtypes, and outcomes among the studied cases, clearly show the complexity of the disease in horses.
  • This research is especially important in providing more insight into the shadowy area of horse health, as specialized studies in equine lymphoma is a relatively scant area.
  • The findings will be instrumental in improving the understanding, diagnosis, and treatment of lymphoma disease in equines.

Cite This Article

APA
Durham AC, Pillitteri CA, San Myint M, Valli VE. (2012). Two hundred three cases of equine lymphoma classified according to the World Health Organization (WHO) classification criteria. Vet Pathol, 50(1), 86-93. https://doi.org/10.1177/0300985812451603

Publication

Veterinary pathology
ISSN: 1544-2217
NlmUniqueID: 0312020
Country: United States
Language: English
Volume: 50
Issue: 1
Pages: 86-93

Researcher Affiliations

Durham, A C
  • Department of Pathobiology, University of Pennsylvania University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA 19104-6051, USA. amycd@vet.upenn.edu
Pillitteri, C A
    San Myint, M
      Valli, V E

        MeSH Terms

        • Animals
        • Female
        • Horse Diseases / classification
        • Horse Diseases / pathology
        • Horses
        • Immunophenotyping / veterinary
        • Lymphoma / classification
        • Lymphoma / pathology
        • Lymphoma / veterinary
        • Male
        • Mitosis
        • Retrospective Studies
        • Skin / pathology
        • World Health Organization

        Citations

        This article has been cited 23 times.
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