Ultrastructural characteristics of nurse cell-larva complex of four species of Trichinella in several hosts.
Abstract: The nurse cell-larva complex of nematodes of the genus Trichinella plays an important role in the survival of the larva in decaying muscles, frequently favouring the transmission of the parasite in extreme environmental conditions. The ultrastructure of the nurse cell-larva complex in muscles from different hosts infected with T. nativa (a walrus and a polar bear), T. spiralis (horses and humans), T. pseudospiralis (a laboratory mouse) and T. papuae (a laboratory mouse) were examined. Analysis with transmission electron microscope showed that the typical nurse cell structure was present in all examined samples, irrespective of the species of larva, of the presence of a collagen capsule, of the age of infection and of the host species, suggesting that there exists a molecular mechanism that in the first stage of larva invasion is similar for encapsulated and non-encapsulated species.
Publication Date: 2001-08-04 PubMed ID: 11484383DOI: 10.1051/parasite/200108s2054Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research paper studies the ultrastructure of the nurse cell-larva complex in four species of Trichinella nematodes across different hosts. It found that the typical nurse cell structure is consistent, suggesting a molecular mechanism that plays a similar role in both encapsulated and non-encapsulated species during the initial stages of larva invasion.
Introduction to the Research
- The research focused on studying the ultrastructure of the nurse cell-larva complex in different species of the genus Trichinella, a type of nematode. The nurse cell-larva complex is crucial for the survival of nematode larvae in decaying muscular tissue.
- The parasite’s survival often encourages the transmission of the parasite in unfavorable environmental conditions, making it interesting to understand the underlying mechanisms.
Methodology
- The researchers examined the ultrastructure of the nurse cell-larva complex in muscles from different hosts. The hosts included a laboratory mouse, humans, and horses, as well as a walrus and a polar bear.
- The four Trichinella species studied were T. nativa, T. spiralis, T. pseudospiralis, and T. papuae.
- Transmission electron microscopy was used for the analysis, enabling detailed visibility of the ultrastructure of the cells.
Key Findings
- The analysis showed that the typical structure of the nurse cell was seen in all examined samples, unaffected by the variables such as the larva species, the presence of a collagen capsule, the host species, or the age of infection.
- This result suggests that a molecular mechanism at the first stage of larva invasion is similar across both encapsulated and non-encapsulated species.
Implications of the Study
- Understanding this molecular mechanism can provide insights into how nematodes of the Trichinella genus survive across different hosts and environmental conditions.
- The results might be of high value in the development of new therapies against these pathogens or in designing control strategies to prevent the transmission of these parasites.
Cite This Article
APA
Sacchi L, Corona S, Gajadhar AA, Pozio E.
(2001).
Ultrastructural characteristics of nurse cell-larva complex of four species of Trichinella in several hosts.
Parasite, 8(2 Suppl), S54-S58.
https://doi.org/10.1051/parasite/200108s2054 Publication
Researcher Affiliations
- Department of Animal Biology, University of Pavia, Pavia, Italy.
MeSH Terms
- Animals
- Humans
- Larva / ultrastructure
- Mice
- Microscopy, Electron
- Muscle, Skeletal / parasitology
- Muscle, Skeletal / pathology
- Muscle, Skeletal / ultrastructure
- Trichinella / physiology
- Trichinella / ultrastructure
- Trichinella spiralis / physiology
- Trichinella spiralis / ultrastructure
- Trichinellosis / pathology
- Trichinellosis / physiopathology
- Ursidae
- Walruses
Citations
This article has been cited 7 times.- Vega-Sánchez V, Gómez-De-Anda FR, Calderón-Domínguez G, Ramírez-Y-Ramírez MC, Reyes-Rodríguez NE, Zepeda-Velázquez AP, Tapia-Romero R, de-la-Rosa-Arana JL. Kinetics of Eosinophils during Development of the Cellular Infiltrate Surrounding the Nurse Cell of Trichinella spiralis in Experimentally Infected Mice.. Pathogens 2021 Oct 26;10(11).
- Liu X, Feng Y, Bai X, Wang X, Qin R, Tang B, Yu X, Yang Y, Liu M, Gao F. Comparative multi-omics analyses reveal differential expression of key genes relevant for parasitism between non-encapsulated and encapsulated Trichinella.. Commun Biol 2021 Jan 29;4(1):134.
- Koutsoumanis K, Allende A, Alvarez-Ordóñez A, Bolton D, Bover-Cid S, Chemaly M, Davies R, De Cesare A, Herman L, Lindqvist R, Nauta M, Peixe L, Ru G, Simmons M, Skandamis P, Suffredini E, Sánchez JÁ, Blagojevic B, Fürst P, Garin-Bastuji B, Jensen HE, Paulsen P, Baert K, Barrucci F, Broglia A, Georgiadis M, Hempen M, Hilbert F. Evaluation of public and animal health risks in case of a delayed post-mortem inspection in ungulates.. EFSA J 2020 Dec;18(12):e06307.
- Somboonpatarakun C, Rodpai R, Intapan PM, Sanpool O, Sadaow L, Wongkham C, Insawang T, Boonmars T, Maleewong W. Immuno-proteomic analysis of Trichinella spiralis, T. pseudospiralis, and T. papuae extracts recognized by human T. spiralis-infected sera.. Parasitol Res 2018 Jan;117(1):201-212.
- Riva E, Steffan P, Guzmán M, Fiel C. Persistence of Trichinella spiralis muscle larvae in natural decaying mice.. Parasitol Res 2012 Jul;111(1):249-55.
- Dvorožňáková E, Hurníková Z, Kołodziej-Sobocińska M. Development of cellular immune response of mice to infection with low doses of Trichinella spiralis, Trichinella britovi and Trichinella pseudospiralis larvae.. Parasitol Res 2011 Jan;108(1):169-76.
- Wu WK, Mak CH, Ko RC. Cloning and differential expression of manganese superoxide dismutase (Mn-SOD) of Trichinella pseudospiralis.. Parasitol Res 2008 Jan;102(2):251-8.
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