Uncoupling Protein-1 (UCP1) in the Adult Horse: Correlations with Body Weight, Rectal Temperature and Lipid Profile.
Abstract: This study aimed to evaluate the possible relationship among UCP1, body weight, rectal temperature and lipid profile in the horse. Thirty clinically healthy Italian Saddle geldings (6-10 years old) were enrolled after the informed owners' consent. All horses were blood sampled and their body weight and rectal temperatures were recorded. On the sera obtained after blood centrifugation the concentration of UCP1, total lipids, phospholipids, non-esterified fatty acids (NEFAs), triglycerides, total cholesterol, high density lipoproteins (HDLs), low density lipoproteins (LDLs) and very low density lipoprotein fraction (VLDLs) was evaluated. Pearson's correlation analysis was applied to assess the possible relationship between serum UCP1 concentration and the values of body weight, rectal temperature and lipid parameters. Serum UCP1 concentration showed no correlation with body weight, rectal temperature, HDLs and LDLs values, whereas it correlated negatively with serum total lipids, phospholipids, NEFAs, total cholesterol, triglycerides and VLDLs values ( < 0.0001). The findings suggest that in the adult horse the role of UCP1 is linked to the lipid metabolism rather than to thermoregulation.
Publication Date: 2021-06-20 PubMed ID: 34202932PubMed Central: PMC8235278DOI: 10.3390/ani11061836Google Scholar: Lookup
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- Journal Article
Summary
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The research analyzes the relationship between a protein named Uncoupling Protein-1 (UCP1) and various bodily measurements and lipid profiles in adult horses, concluding that UCP1’s role is primarily associated with lipid metabolism, not thermoregulation or body weight.
Objective of the Study
- The purpose of this research was to determine the relationship between UCP1, body weight, rectal temperature, and lipid profile in adult horses. The focus is on UCP1 because it plays a substantial role in energy metabolism and thermogenesis (production of heat) in mammals.
Methods and Materials
- Thirty healthy Italian Saddle geldings aged 6-10 years old were selected for the study. The body weights and rectal temperatures of all the horses were noted. Furthermore, their blood was collected and separated via centrifugation to obtain serum – the liquid portion of the blood where proteins like UCP1 are present.
- Various factors were measured in the serum, including the concentration of UCP1, total lipids, phospholipids, non-esterified fatty acids (NEFAs), triglycerides, total cholesterol, high-density lipoproteins (HDLs), low-density lipoproteins (LDLs), and very low-density lipoprotein fraction (VLDLs).
Statistical Analysis
- Correlation analysis was employed with the Pearson’s correlation method to see if there were any relationships between serum UCP1 concentration and the values of body weight, rectal temperature, and lipid parameters.
Results and Discussion
- UCP1 concentration showed no correlation with body weight, rectal temperature, and HDLs and LDLs values. In other words, the levels of UCP1 in the horses’ blood did not seem to have any relationship to how much the horses weighed, their body temperature, or their levels of certain types of cholesterol.
- However, a significant negative correlation was found between UCP1 concentration and the values of total lipids, phospholipids, NEFAs, total cholesterol, triglycerides, and VLDLs. This means as the UCP1 levels increased, the levels of these lipids decreased, signaling an inverse relationship.
- Based on these findings, the researchers concluded that in adult horses, UCP1 is more associated with lipid metabolism (the breakdown and use of fats for energy) rather than thermogenesis or thermoregulation (the maintenance of body temperature).
Cite This Article
APA
Arfuso F, Giannetto C, Panzera MF, Fazio F, Piccione G.
(2021).
Uncoupling Protein-1 (UCP1) in the Adult Horse: Correlations with Body Weight, Rectal Temperature and Lipid Profile.
Animals (Basel), 11(6), 1836.
https://doi.org/10.3390/ani11061836 Publication
Researcher Affiliations
- Department of Veterinary Sciences, University of Messina, Polo Universitario dell'Annunziata, 98168 Messina, Italy.
- Department of Veterinary Sciences, University of Messina, Polo Universitario dell'Annunziata, 98168 Messina, Italy.
- Department of Biomedical, Dental, Morphological and Functional Images, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
- Department of Veterinary Sciences, University of Messina, Polo Universitario dell'Annunziata, 98168 Messina, Italy.
- Department of Veterinary Sciences, University of Messina, Polo Universitario dell'Annunziata, 98168 Messina, Italy.
Conflict of Interest Statement
The authors declare no conflict of interest.
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Citations
This article has been cited 1 times.- Daradics Z, Niculae M, Crecan CM, Lupșan AF, Rus MA, Andrei S, Ciobanu DM, Cătoi FA, Pop ID, Mircean MV, Cătoi C. Clustering and Correlations amongst NEFA, Selected Adipokines and Morphological Traits-New Insights into Equine Metabolic Syndrome.. Animals (Basel) 2022 Oct 20;12(20).
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