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Home / Equine Research Bank / Aust Vet J / Unusual ovarian activity in a mare preceding the development...
Australian veterinary journal2002; 80(1-2); 32-36;

Unusual ovarian activity in a mare preceding the development of an ovarian granulosa cell tumour.

Abstract: An 8-year-old mare, with a foal at foot, was inseminated on foal heat with frozen semen, with the resultant pregnancy lost between days 34 and 41. The right ovary developed a large anovulatory follicle that was non-responsive to multiple doses of ovulating agents. The follicle eventually appeared to luteinise, although plasma progesterone concentrations did not reflect this. Another follicle developed, responded to GnRH and resulted in a pregnancy from frozen semen that went to term with a healthy foal. When the mare was examined after foaling, the structure on the right ovary appeared to be a granulosa cell tumour; the left ovary was smaller than normal and non-functional. Surgical removal of the right ovary before increasing photoperiod resulted in a return to function of the left ovary and a pregnancy to frozen semen on the second cycle following removal. Figures showing concentrations of inhibin, progesterone, androstenedione, oestradiol and testosterone are presented for this entire period. Unusual ovarian activity in the mare might be a prelude to the development of a granulosa cell tumour.
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Publication Date: 2002-08-16 PubMed ID: 12180875
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article describes a case of a mare that showed an uncommon ovarian behavior before developing an ovarian granulosa cell tumour. The researchers documented the mares ovarian activity, hormonal changes, and the eventual surgery and recovery.

Research Background and Purpose

  • The intent of this study was to analyze unusual ovarian activities in a mare and to determine if such unusual activities could serve as indicators of the looming development of an ovarian granulosa cell tumor.

Research Procedures and Observations

  • An 8-year-old mare was the subject of this study.
  • This mare had successfully produced a foal but lost a subsequent pregnancy fertilized with frozen semen between days 34 and 41.
  • The right ovary of the mare developed a large anovulatory follicle. Despite administering ovulating agents, the follicle did not respond. Although it appeared to luteinise later, plasma progesterone concentrations did not reflect this.
  • The mare then expressed another follicle, this time reacting to Gonadotropin-Releasing Hormone (GnRH), and became pregnant with frozen semen, which resulted in a full-term pregnancy and a healthy foal.

Identification of the Tumour and Surgery

  • Post-foaling examination of the mare revealed that the structure on the right ovary was a granulosa cell tumour. Additionally, the left ovary was non-functional and smaller than usual.
  • The researchers decided to surgically remove the right ovary and discovered that the left ovary returned to its normal function and led the subsequent cycle to pregnancy after being inseminated with frozen semen for the second time.

Data and Results

  • The researchers presented figures showing variations in hormone concentrations – inhibin, progesterone, androstenedione, estradiol, and testosterone – throughout the entire period of the study.
  • The main result of this study was the discovery of a possible link between irregular ovarian activity and the eventual emergence of ovarian granulosa cell tumors in mares.

Cite This Article

APA
Chopin JB, Chopin LK, Knott LM, de Kretser DM, Dowsett KF. (2002). Unusual ovarian activity in a mare preceding the development of an ovarian granulosa cell tumour. Aust Vet J, 80(1-2), 32-36.

Publication

Australian veterinary journal
ISSN: 0005-0423
NlmUniqueID: 0370616
Country: England
Language: English
Volume: 80
Issue: 1-2
Pages: 32-36

Researcher Affiliations

Chopin, J B
  • Oakey Veterinary Hospital, Queensland.
Chopin, L K
    Knott, L M
      de Kretser, D M
        Dowsett, K F

          MeSH Terms

          • Animals
          • Diagnosis, Differential
          • Female
          • Granulosa Cell Tumor / blood
          • Granulosa Cell Tumor / diagnosis
          • Granulosa Cell Tumor / veterinary
          • Hormones / blood
          • Horse Diseases / diagnosis
          • Horse Diseases / pathology
          • Horse Diseases / surgery
          • Horses
          • Ovarian Neoplasms / blood
          • Ovarian Neoplasms / diagnosis
          • Ovarian Neoplasms / veterinary
          • Ovary / metabolism

          Citations

          This article has been cited 2 times.
          1. Wolf N, Hahn JA, Walter I, Zablotski Y, Zerbe H, Witte TS. Pathohistological Findings after Bilateral Ovariectomy in Mares with Behavioral Problems. Animals (Basel) 2024 Oct 8;14(19).
            doi: 10.3390/ani14192899pubmed: 39409848google scholar: lookup
          2. Frederico LM, Gerard MP, Pinto CR, Gradil CM. Bilateral occurrence of granulosa-theca cell tumors in an Arabian mare. Can Vet J 2007 May;48(5):502-5.
            pubmed: 17542368
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