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[Use of a mix of lidocaine and butorphanol as a caudal epidural anesthesia in a mare].

Abstract: Loss of rear motor control is the main limiting factor in the use of caudal epidural anesthesia in the horse. In man and laboratory animals, a small dose of an opiate combined with a local anesthetic enhances analgesia without impairing motor function. Thus, the amount of local anesthetic administered may be reduced. Butorphanol is an opiate widely used in horses. It has a good margin of safety and few cardiorespiratory effects. The effects of lidocaine (0.25 mg/kg) and lidocaine-butorphanol (0.25 mg/kg, and 0.04 mg/kg, respectively) were compared in 2 groups of 5 healthy unsedated mares. Horses in each group received either lidocaine or lidocaine-butorphanol in saline solution for a total volume of 0.0165 mg/kg. Epidural injection was performed at the first coccygeal interspace. Each mare was used only once. Cutaneous analgesia was assessed by a response to a pin prick; and visceral analgesia was assessed by response to a noxious stimulus applied to the urethra. Heart rate, respiratory rate, and arterial blood pressure were also measured. Analysis of the results showed an increase in duration of both cutaneous and visceral analgesia in the mares given lidocaine-butorphanol. Cutaneous analgesia increased from 36 +/- 13 to 150 +/- 21 min and visceral analgesia increased from 22 +/- 10 to 162 +/- 16 min. A cranial extension of the cutaneous analgesia was also observed. Cardiorespiratory depression or signs of excitation were not observed. However, these mares demonstrated peculiar walking in the hind limbs, not associated with signs of ataxia or hyperkinesia. Loss of rear motor control is the main limiting factor in the use of caudal epidural anesthesia in the horse. In man and laboratory animals, a small dose of an opiate combined with a local anesthetic enhances analgesia without impairing motor function. Thus, the amount of local anesthetic administered may be reduced. Butorphanol is an opiate widely used in horses. It has a good margin of safety and few cardiorespiratory effects. The effects of lidocaine (0.25 mg/kg) and lidocaine-butorphanol (0.25 mg/kg, and 0.04 mg/kg, respectively) were compared in 2 groups of 5 healthy unsedated mares. Horses in each group received either lidocaine or lidocaine-butorphanol in saline solution for a total volume of 0.0165 mg/kg. Epidural injection was performed at the first coccygeal interspace. Each mare was used only once. Cutaneous analgesia was assessed by a response to a pin prick; and visceral analgesia was assessed by response to a noxious stimulus applied to the urethra. Heart rate, respiratory rate, and arterial blood pressure were also measured. Analysis of the results showed an increase in duration of both cutaneous and visceral analgesia in the mares given lidocaine-butorphanol. Cutaneous analgesia increased from 36 +/- 13 to 150 +/- 21 min and visceral analgesia increased from 22 +/- 10 to 162 +/- 16 min. A cranial extension of the cutaneous analgesia was also observed. Cardiorespiratory depression or signs of excitation were not observed. However, these mares demonstrated peculiar walking in the hind limbs, not associated with signs of ataxia or hyperkinesia.
Publication Date: 1996-10-01 PubMed ID: 9026402PubMed Central: PMC1263851
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  • English Abstract
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

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The research article examines the effects of using a combination of lidocaine and butorphanol for caudal epidural anesthesia in horses, and finds that the mix enhances analgesia and extends its duration without causing significant adverse effects.

Introduction

  • This paper examines the benefits and limitations of using caudal epidural anesthesia in horses. The primary drawback of this method is the loss of motor control in the rear.
  • Based on observations in human and laboratory animals, a small amount of an opiate mixed with a local anesthetic can enhance analgesia without impairing motor function.
  • Therefore, the researchers decided to explore the impact of combining butorphanol, an opiate commonplace in equine treatment, with lidocaine, a local anesthetic, in mares.

Methodology

  • Two groups of five healthy unsedated mares were used in the study. Each horse was only used once.
  • One group received lidocaine alone (0.25 mg/kg), whilst the other was given lidocaine (0.25 mg/kg) and butorphanol (0.04 mg/kg) in a saline solution, with a total volume of 0.0165 mg/kg.
  • The injections were performed epidurally at the first coccygeal interspace.
  • The effectiveness of the anesthesia was measured in two ways: cutaneous (skin surface) analgesia evaluated by the animal’s reaction to a pin prick, and visceral (internal organs) analgesia assessed by the horse’s reaction to a painful stimulus in the urethra.
  • Other variables tracked were the horse’s heart rate, respiration rate, and arterial blood pressure.

Findings

  • The mares given the lidocaine-butorphanol combination showed a notable increase in the duration of both cutaneous and visceral analgesia compared to the mares given lidocaine alone. The duration of cutaneous analgesia increased from around 36 minutes to 150 minutes and visceral analgesia increased from approximately 22 minutes to 162 minutes.
  • A cranial (towards the head) extension of analgesia was also observed; meaning the area of numbness moved towards the head.
  • No significant cardiorespiratory depression or signs of hyperactivity were noted in the mares given the combination treatment.
  • However, these mares exhibited unusual walking patterns in their hind limbs, which was not linked to any signs of ataxia (loss of control of bodily movements) or hyperkinesia (excessive movement).

Cite This Article

APA
Csik-Salmon J, Blais D, Vaillancourt D, Garon O, Bisaillon A. (1996). [Use of a mix of lidocaine and butorphanol as a caudal epidural anesthesia in a mare]. Can J Vet Res, 60(4), 288-295.

Publication

ISSN: 0830-9000
NlmUniqueID: 8607793
Country: Canada
Language: fre
Volume: 60
Issue: 4
Pages: 288-295

Researcher Affiliations

Csik-Salmon, J
  • Département de biomédecine Vétérinaire, Faculté de médecine Vétérinaire, Université de Montreal, Saint-Hyacinthe, Québec.
Blais, D
    Vaillancourt, D
      Garon, O
        Bisaillon, A

          MeSH Terms

          • Analgesics, Opioid / pharmacology
          • Anesthesia, Epidural / methods
          • Anesthesia, Epidural / veterinary
          • Anesthetics, Local / pharmacology
          • Animals
          • Blood Pressure / drug effects
          • Blood Pressure / physiology
          • Butorphanol / pharmacology
          • Female
          • Heart Rate / drug effects
          • Heart Rate / physiology
          • Horses / physiology
          • Lidocaine / pharmacology
          • Motor Activity / drug effects
          • Motor Activity / physiology
          • Respiration / drug effects
          • Respiration / physiology

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          Citations

          This article has been cited 1 times.
          1. Nahas AE, Almubarak AI, Hagag U. Epidural lidocaine, butorphanol, and butorphanol - lidocaine combination in dromedary camels.. BMC Vet Res 2023 Feb 16;19(1):51.
            doi: 10.1186/s12917-023-03601-8pubmed: 36797763google scholar: lookup