Use of a three-blood-sample plasma clearance technique to measure GFR in horses.
Abstract: Measurement of renal function in horses poses a particular challenge because plasma creatinine is influenced by muscle mass which is highly developed and variable between individuals, while conventional clearance methods involve potentially daunting problems, particularly urine collection and bladder washout. This paper provides data which enable technetium-diethyleneaminopentacetic acid (Tc-DTPA) clearance to be used to calculate glomerular filtration rate (GFR)/extracellular fluid volume (ECFV) as an expression of GFR in horses, as previously validated in humans, dogs and calves. Apart from being arguably a more physiological expression of GFR than using derivatives of body weight, the use of GFR/ECFV eliminates a source of delay and error, namely measurement of the injected dose, and offers the convenience of requiring only three blood samples. It therefore has advantages for both research and clinical applications.
Copyright 1999 Harcourt Publishers Ltd.
Publication Date: 1999-11-24 PubMed ID: 10558840DOI: 10.1053/tvjl.1999.0385Google Scholar: Lookup
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- Journal Article
Summary
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The research article is about a newly proposed method for measuring kidney function in horses, namely the glomerular filtration rate (GFR), using a three-blood-sample plasma clearance technique with technetium-diethyleneaminopentacetic acid. This approach simplifies procedures and reduces errors associated with traditional methods.
Background
- This paper discusses the challenges of measuring renal function in horses, as conventional indicators such as plasma creatinine can be unreliable due to variables such as muscle mass in individual horses.
- Moreover, traditional evaluation methods involving urine collection and bladder washout have some problematic implications and limitations, which may lead to inaccurate measurements.
Method
- The researchers propose a new measurement approach, using a three-blood-sample plasma clearance method in combination with a solution containing technetium-diethyleneaminopentacetic acid (Tc-DTPA).
- Tc-DTPA is strategically cleared from the body and is thus useful in estimating the glomerular filtration rate (GFR), which indicates how well the kidneys are functioning.
- This three-sample method allows for an assessment of renal function that requires only three blood samples, making the process more convenient and potentially eliminating sources of inaccuracies and delay.
Results and Implications
- By using the Tc-DTPA clearance to calculate the ratio of GFR to the extracellular fluid volume (ECFV), this study offers a new way to express GFR in horses that may be more physiologically accurate than current metrics relying on body weight derivatives.
- The use of the GFR/ECFV ratio also provides the advantage of circumventing the need to precisely measure the injected dose, eliminating a common source of error in traditional methods.
- Overall, the proposed method presents clear advantages for both research investigations and practical clinical applications, offering a potential new standard for renal function measurement in horses.
Cite This Article
APA
Gleadhill A, Marlin D, Harris PA, Michell AR.
(1999).
Use of a three-blood-sample plasma clearance technique to measure GFR in horses.
Vet J, 158(3), 204-209.
https://doi.org/10.1053/tvjl.1999.0385 Publication
Researcher Affiliations
- Formerly Royal Veterinary College, University of London, UK.
MeSH Terms
- Animals
- Body Weight
- Glomerular Filtration Rate / veterinary
- Horses / physiology
- Radiopharmaceuticals
- Reference Values
- Sensitivity and Specificity
- Technetium Tc 99m Pentetate
Citations
This article has been cited 3 times.- Lloyd LJ, Foster T, Rhodes P, Rhind SM, Gardner DS. Protein-energy malnutrition during early gestation in sheep blunts fetal renal vascular and nephron development and compromises adult renal function.. J Physiol 2012 Jan 15;590(2):377-93.
- Satoh H, Abe S, Kato M, Saito J, Furuhama K. Optimum conditions for serum clearance of iodixanol, applicable to the estimation of glomerular filtration rate in horses.. Vet Res Commun 2011 Oct;35(7):463-8.
- Williams PJ, Kurlak LO, Perkins AC, Budge H, Stephenson T, Keisler D, Symonds ME, Gardner DS. Hypertension and impaired renal function accompany juvenile obesity: the effect of prenatal diet.. Kidney Int 2007 Aug;72(3):279-89.
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