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Home / Equine Research Bank / Aust Vet J / Use of intralesional cisplatin to successfully treat distal ...
Australian veterinary journal2023; 101(8); 308-312; doi: 10.1111/avj.13251

Use of intralesional cisplatin to successfully treat distal limb haemangiosarcoma in a foal.

Abstract: A 4-month old, 200 kg, grey warmblood colt presented for a firm, non painful mass on the distal medial aspect of the left third metatarsus. Excisional biopsy revealed a diagnosis of haemangiosarcoma. Equine haemangiosarcoma is uncommon and only limited reports of successful treatment are available. The prognosis for survival is therefore considered to be poor. After two separate incidences of recurrence with incomplete excision of the tumour, intralesional treatment with cisplatin without excision or debulking was performed on three separate occasions. Intralesional cisplatin injection was performed at monthly intervals for three treatments. Four years post treatment with cisplatin, the horse remained in remission. This case report describes the diagnostic and treatment challenges for successful treatment of a primary haemangiosarcoma on the distal limb of a warmblood foal using intralesional cisplatin chemotherapy.
© 2023 Australian Veterinary Association.
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Publication Date: 2023-06-08 PubMed ID: 37291800DOI: 10.1111/avj.13251Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses a case where a foal with an uncommon cancer known as hemangiosarcoma was successfully treated with localized cisplatin injections, despite difficulties in excising the tumor.

Case Presentation

  • The subject of this study was a 4-month old, 200kg, warmblood colt with a firm, non-painful mass situated on the distal medial aspect of its left third metatarsus.
  • An excisional biopsy indicated that the mass was actually a hemangiosarcoma, a type of cancer that is considered rare for equines.
  • The prognosis for this condition is generally poor and there are very few instances of successful treatment noted in medical literature.

Treatment Methodology and Outcome

  • The tumor was excised twice but regrew on both occasions, indicating the difficulty of complete removal through surgery.
  • Therefore, a different approach was tried – the tumor was treated with cisplatin, a chemotherapy drug, without conducting excision or debulking surgery.
  • The cisplatin was injected directly into the tumor (this is known as “intralesional” treatment) on three separate occasions spaced roughly a month apart.
  • The horse remained in remission (no sign of cancer recurrence) four years after the cisplatin treatment.

Significance of the Case Report

  • This case report is notable because it demonstrates a successful application of intralesional cisplatin chemotherapy for treating primary hemangiosarcoma in an equine patient.
  • Given that hemangiosarcoma is unusual in horses and has a poor survival prognosis, alternative treatment avenues like this one could offer hope for future cases.
  • The study also documents the difficulties encountered in diagnosing and managing the condition, which could serve as a helpful guide for veterinarians dealing with similar cases.

Cite This Article

APA
Norton AM, McGilp D, Vasey JR. (2023). Use of intralesional cisplatin to successfully treat distal limb haemangiosarcoma in a foal. Aust Vet J, 101(8), 308-312. https://doi.org/10.1111/avj.13251

Publication

Australian veterinary journal
ISSN: 1751-0813
NlmUniqueID: 0370616
Country: England
Language: English
Volume: 101
Issue: 8
Pages: 308-312

Researcher Affiliations

Norton, A M
  • Goulburn Valley Equine Hospital, Shepparton, Victoria, Australia.
McGilp, D
  • School of Veterinary Science, Building 8114, The University of Queensland, Gatton, QLD, 4343, Australia.
Vasey, J R
  • Goulburn Valley Equine Hospital, Shepparton, Victoria, Australia.

MeSH Terms

  • Animals
  • Male
  • Horses
  • Cisplatin / therapeutic use
  • Hemangiosarcoma / drug therapy
  • Hemangiosarcoma / veterinary
  • Hemangiosarcoma / diagnosis
  • Prognosis
  • Horse Diseases / diagnosis

References

This article includes 18 references
  1. Taintor J. Haemangiosarcoma in the horse.. Equine Vet Educ 2014;26:499-503.
  2. Johns I, Stephen JO, Del PF. Hemangiosarcoma in 11 young horses.. J Vet Intern Med 2005;19:564-570.
  3. Southwood LL, Harold II, Henry CJ. Disseminated hemangiosarcoma in the horse: 35 cases.. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2000;14:105-109.
  4. Collins MB, Hodgson DR, Hutchins DR. Haemangiosarcoma in the horse: three cases.. Aust Vet J 1994;71:296-298.
  5. Byrne DP, Woolford L, Booth TM. Penile haemangiosarcoma in a breeding stallion.. Equine Vet Educ 2016;28:304-309.
  6. Vázquez Bringas FJ, Romero Lasheras A, Laborda García A. Treatment of congenital atypical haemangiosarcoma in a foal.. Equine Vet Educ 2023;00:1-9.
  7. Scherrer NM, Lassaline M, Engiles J. Ocular and periocular hemangiosarcoma in six horses.. Vet Ophthalmol 2018;21:432-437.
  8. Clifford CA, Mackin AJ, Henry CJ. Treatment of canine hemangiosarcoma: 2000 and beyond.. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2000;14:479-485.
  9. Sorenmo K, Duda L, Barber L. Canine hemangiosarcoma treated with standard chemotherapy and minocycline.. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2000;14:395-398.
  10. Théon A, Galuppo L, Snyder J. Intratumoral Administration of Cisplatin for treatment of Sarcoids in 378 horses.. AAEP Proceedings 2006;52:337-339.
  11. Taylor S, Haldorson G. A review of equine sarcoid 2012.. .
  12. Miller TT. Bone tumors and tumorlike conditions: analysis with conventional radiography.. Radiology 2008;246:662-674.
  13. Pinn TL, Cushing T, Valentino LM. Corneal invasion by hemangiosarcoma in a horse.. Vet Ophthalmol 2011;14:200-204.
  14. Hewes CA, Sullins KE. Use of cisplatin for treatment of cutaneous neoplasia in Equidae.. J Am Vet Med Assoc 2006;229:1617-1622.
  15. Hewes C, Sullins K. Use of cisplatin-containing biodegradable beads for treatment of cutaneous neoplasia in equidae: 59 cases (2000-2004).. J Am Vet Med Assoc 2006;229:1617-1622.
  16. Théon AP, Wilson WD, Magdesian KG. Long-term outcome associated with intratumoral chemotherapy with cisplatin for cutaneous tumors in equidae: 573 cases (1995-2004).. J Am Vet Med Assoc 2007;230:1506-1513.
  17. Makovec T. Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy.. Radiol Oncol 2019;53:148-158.
  18. Intratumoral chemotherapy with cisplatin in oily emulsion in horses. PubMed - NCBI. https://www.ncbi.nlm.nih.gov/pubmed/8428832

Citations

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