Use of multifrequency bioelectrical impedance analysis for estimation of total body water and extracellular and intracellular fluid volumes in horses.
Abstract: To evaluate the use of multifrequency bioelectrical impedance analysis (MF-BIA) for estimating total body water (TBW), extracellular fluid volume (ECFV), and intracellular fluid volume (ICFV) in horses. Methods: 9 healthy mares. Methods: TBW and ECFV were measured by use of deuterium oxide and sodium bromide dilution techniques, respectively. Intracellular fluid volume was calculated as the difference between TBW and ECFV. Concurrently, MF-BIA recordings were obtained by use of 4 anatomic electrode positions and 3 measurements of length. Models for MF-BIA data were created for all combinations of length and anatomic electrode position. Models were evaluated to determine the position-length configuration that provided the most consistent estimates of TBW, ECFV, and ICFV, compared with values determined by use of the dilution techniques. Results: Positioning electrodes over the ipsilateral carpus and tarsus and use of height at the tuber sacrale for length provided the closest estimate between values for TBW, ECFV, and ICFV predicted by use of MF-BIA and measured values obtained by dilutional techniques. This model had the narrowest 95% limits of agreement. Conclusions: MF-BIA techniques have been used to predict changes in TBW, ECFV, and ICFV in healthy and diseased humans. Results reported in this study provide an equine-specific model to serve as the basis for further evaluation of MF-BIA in horses with altered fluid states. The MF-BIA techniques have a number of potential applications for use in horses, including evaluation of exercise physiology, pharmacologic studies, and critical-care management.
Publication Date: 2004-03-19 PubMed ID: 15027680DOI: 10.2460/ajvr.2004.65.320Google Scholar: Lookup
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research evaluates the use of multifrequency bioelectrical impedance analysis (MF-BIA) for estimating the body’s total water, extracellular and intracellular fluid volumes in horses. The findings suggest that these techniques, which have been applied in human health studies, can also be beneficial in equine health studies such as exercise physiology, pharmaceutical studies, and critical-care management.
Overview of Research Methods
- The research involved nine healthy mares (female horses).
- Total Body Water (TBW) and Extracellular Fluid Volume (ECFV) were measured using dilution techniques with deuterium oxide and sodium bromide, respectively.
- Intracellular Fluid Volume (ICFV) was calculated by finding the difference between TBW and ECFV readings.
- Simultaneously, MF-BIA readings were obtained using four anatomical electrode positions and three measurements of length.
- Different models for MF-BIA data were created for every length and anatomical electrode position combination.
- These models were then evaluated to determine which position-length configuration gave the most consistent estimates of TBW, ECFV, and ICFV when compared with values attained via dilution techniques.
Research Findings
- The researchers found that positioning electrodes over the ipsilateral carpus (the horse’s equivalent of the human wrist) and tarsus (equivalent to the human ankle), and using height at the tuber sacrale (part of the horse’s pelvis) for length, provided the closest estimate between the TBW, ECFV, and ICFV values predicted by MF-BIA and those measured with dilutional techniques. This model had the narrowest 95% limits of agreement.
Implications and Conclusions
- MF-BIA techniques, which have previously been applied to monitor changes in TBW, ECFV, and ICFV in healthy and diseased humans, are promising in horse health studies.
- Findings from this research offer an equine-specific model for the further evaluation of MF-BIA in horses, particularly those with altered fluid states.
- There are potential applications in exercise physiology, pharmacological studies, and critical-care management.
Cite This Article
APA
Fielding CL, Magdesian KG, Elliott DA, Cowgill LD, Carlson GP.
(2004).
Use of multifrequency bioelectrical impedance analysis for estimation of total body water and extracellular and intracellular fluid volumes in horses.
Am J Vet Res, 65(3), 320-326.
https://doi.org/10.2460/ajvr.2004.65.320 Publication
Researcher Affiliations
- Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
MeSH Terms
- Animals
- Body Water / physiology
- Bromides
- Deuterium Oxide
- Electric Impedance
- Extracellular Fluid / physiology
- Horses / physiology
- Models, Biological
- Sodium Compounds
Citations
This article has been cited 2 times.- Greco-Otto P, Léguillette R. Assessment of body fluids and blood parameters associated with rapid weight change in heavy horses. Can Vet J 2019 Jul;60(7):721-724.
- Greco-Otto PR, Léguillette R. Determination of body proportion factor in draft horses for the use of bioimpedance spectroscopy. Can Vet J 2018 Jun;59(6):650-653.
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