[Use of trichlorfon as an anthelmintic in horses (author’s transl)].

The study focuses on evaluating the effects and risks associated with the use of trichlorfon, a commonly used anthelmintic in horses. The researchers found evidence of frequent incidences of poisoning, especially when coupled with other drugs, leading to conditions such as colic, diarrhoea, and anorexia in horses. It is suggested that the use of accurate horse weight measuring methods should be applied to prevent overdosing.

Research Context

• The use of trichlorfon as an anthelmintic (de-worming agent) in horses has been expanding, especially when it’s merged with other drugs like mebendazole and febantel.
• Trichlorfon is usually available commercially as Telmin-trichlorfon or Rintal-plus when combined with the aforementioned drugs.
• The research aimed to assess whether this combined usage has any side effects or health complications for the horses.

Research Findings

• The study found that these combined medications often led to instances of poisoning in horses.
• Clinical symptoms vary from mild to severe colic that was noticeable up to six hours following treatment.
• Other conditions such as diarrhoea and/or anorexia were also seen lasting one to six days post-administration.
• These conditions indicate that the combined therapy is not always well-tolerated by horses and could lead to significant health problems.

Practical Implications

• The ‘horse weight measurer’ presented by Janssen Pharmaceutica was found not to provide accurate enough data to prevent overdosing.
• Overdosing can lead to negative health effects on the horses, making it a significant concern for veterinarians and horse caretakers.
• Consequently, the researchers advised that trichlorfon should only be used when the horse’s body weight can be accurately gauged by a reliable method.
• This practice would ensure the correct dosage of the drug and help to minimize the risk of overdosing and related complications.