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Home / Equine Research Bank / Animals (Basel) / Usefulness of Selected Acute-Phase Proteins in the Postsurgi...
Animals : an open access journal from MDPI2021; 11(10); doi: 10.3390/ani11102952

Usefulness of Selected Acute-Phase Proteins in the Postsurgical Monitoring of Arthroscopy and Splint Bone Removal in Horses.

Abstract: Arthroscopy and splint bone removal are the common orthopedic procedures in horses. Estimation of the dynamics of acute phase proteins in postoperative monitoring seems to be interesting diagnostic approach. The aim of the study was to investigate changes in the concentrations of plasma inflammatory markers-fibrinogen, haptoglobin, and protease inhibitors-following orthopedic surgery in horses. The study involved 114 horses, divided into two study groups undergoing: arthroscopy (41 horses) and splint bone removal (13 horses). The control group consisted of 60 healthy horses. The blood was collected before the surgery and 24, 48, 72 h, 5, 7, 10, 14 and 28 days after the surgery. Plasma fibrinogen, serum haptoglobin and proteinase inhibitors were measured. Results: In non-complicated cases of arthroscopy and splint bone removal, fibrinogen and haptoglobin increased stepwise from 24 h, achieved the maximum level at 72 h and returned to preoperative levels after 10-14 days. In one complicated case after arthroscopy surgery the marked increase in fibrinogen and haptoglobin concentrations was observed 24 h earlier than standard parameters of inflammation Conclusion: The study shows the evolution of APPs after arthroscopy and splint bone removal in 28 days postsurgery period and in the case of one complicated case of arthroscopy.
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Publication Date: 2021-10-13 PubMed ID: 34679973PubMed Central: PMC8532912DOI: 10.3390/ani11102952Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research aims to examine the efficacy of acute phase proteins in postoperative monitoring for horses who undergo arthroscopy and splint bone removal. The scientists employed plasma inflammatory markers such as fibrinogen, haptoglobin, and protease inhibitors, to assess the overall recovery process.

Research Aim and Methodology

  • The goal of the study was to track variations in the concentrations of plasma inflammatory markers – fibrinogen, haptoglobin, and protease inhibitors – subsequent to orthopedic surgeries in horses. The motivation behind this research was to explore a potential diagnostics tool for postoperative monitoring.
  • The experiment involved 114 horses in total, divided into two categories: 41 horses undergoing arthroscopy, and 13 horses undergoing splint bone removal. These are two common orthopedic procedures in horses. The control group was composed of 60 healthy horses.
  • Blood samples were collected from each horse before surgery and at various intervals post-surgery (24, 48, 72 hours, and 5, 7, 10, 14, and 28 days after).

Conclusion & Findings

  • In uncomplicated arthroscopy and splint bone removal cases, the concentrations of fibrinogen and haptoglobin increased gradually from 24 hours after the surgery, reached a peak level at 72 hours, and returned back to their preoperative levels between 10 to 14 days post-surgery.
  • In one complicated case following arthroscopy, a significant rise in fibrinogen and haptoglobin concentrations was observed 24 hours earlier than standard inflammation parameters. This suggests that the tracking of these protein levels can be a valuable tool in early detection of post-surgery complications.
  • The study demonstrates the progression of acute phase proteins post-arthroscopy and splint bone removal over a span of 28 days and highlights its potential use in post-operative care and monitoring.

Cite This Article

APA
Przewoźny M, Senderska-Płonowska M, Rząsa A, Wierzbicki H, Borkowski J, Swagemakers JH, Żak-Bochenek A, Stefaniak T. (2021). Usefulness of Selected Acute-Phase Proteins in the Postsurgical Monitoring of Arthroscopy and Splint Bone Removal in Horses. Animals (Basel), 11(10). https://doi.org/10.3390/ani11102952

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 10

Researcher Affiliations

Przewoźny, Maciej
  • Klinika dla Koni Equi Vet Serwis Dr Maciej Przewoźny, 64-320 Buk, Poland.
Senderska-Płonowska, Magdalena
  • Department of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wrocław University of Environmental and Life Sciences, 50-137 Wrocław, Poland.
Rząsa, Anna
  • Department of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wrocław University of Environmental and Life Sciences, 50-137 Wrocław, Poland.
Wierzbicki, Heliodor
  • Department of Genetics, University of Environmental and Life Sciences, 50-137 Wrocław, Poland.
Borkowski, Jacek
  • Department of Biochemistry, Academy of Physical Education, 50-137 Wrocław, Poland.
Swagemakers, Jan-Hein
  • Tierärztliche Klinik für Pferde in Lüsche, 49456 Bakum, Germany.
Żak-Bochenek, Agnieszka
  • Department of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wrocław University of Environmental and Life Sciences, 50-137 Wrocław, Poland.
Stefaniak, Tadeusz
  • Department of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wrocław University of Environmental and Life Sciences, 50-137 Wrocław, Poland.

Conflict of Interest Statement

The authors declare that they have no competing interests.

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