Uterine transport of prostaglandin E(2)-releasing simulated embryonic vesicles in mares.
Abstract: Transrectal ultrasonography was used to test the hypothesis that prostaglandin E(2) (PGE(2)) would increase the uterine transport of simulated embryonic vesicles in mares. Uterine transport of PGE(2)-releasing (PGE) vesicles, vehicle-releasing (sham) vesicles, and equine embryos was contrasted on Day 12 or Day 13 post ovulation. In Experiment 1, there was no difference (P>0.10) in transport of PGE vesicles, sham vesicles, Day-12 embryos, and Day-12 embryos after cervical manipulation (n = 3 per group). In Experiments 2 and 3, respectively, transport of PGE and sham vesicles was contrasted with transport of Day-13 embryos after the vesicles (1 vesicle per mare) were placed into the uterine lumen with the embryo, (n = 7 per group). In Experiment 2, PGE vesicles were transported less often (P<0.05) from horn to body and from segment to segment than Day-13 embryos before vesicle insertion. In Experiment 3, sham vesicles were transported less often from horn to body (P<0.10) and from segment to segment (P<0.01) than Day-13 embryos before vesicle insertion. However, there was no difference (P>0.10) in the transport of PGE vesicles and embryos (Experiment 2) or sham vesicles and embryos (Experiment 3) together in the uterine lumen. In Experiment 4, transport of PGE and sham vesicles was contrasted by placing them together into the uterine lumen of nonpregnant mares on Day 13 (n = 7). There was no difference (P>0.10) in the transport of PGE and sham vesicles together in the uterine lumen. These results do not support the hypothesis that PGE(2) increases uterine transport of simulated embryonic vesicles. In addition, these results do not support the hypothesis that equine embryos stimulate uterine transport.
Publication Date: 1993-07-01 PubMed ID: 16727290DOI: 10.1016/0093-691x(93)90337-5Google Scholar: Lookup
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Summary
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The research aimed to investigate if prostaglandin E2 (PGE2) increases the uterine transport of simulated embryonic vesicles in mares, using transrectal ultrasonography. The study found no significant difference in uterine transport with or without PGE2, nor with real or simulated embryos, contradicting the hypothesis.
Methodology
- The researchers used Transrectal Ultrasonography to study the uterine transport of PGE2-releasing vesicles, vehicle-releasing (sham) vesicles, and equine embryos on the 12th and 13th day after ovulation.
- The study was divided into four experiments, each with different scenarios to compare the transportation variations of PGE and sham vesicles and embryos.
Results from the experiments
- In the first experiment, the researchers found no significant difference (P>0.10) in the transport of PGE vesicles, sham vesicles, and embryos, whether that’s on the 12th day or 12th day post cervical manipulation. This experiment involved 3 subjects per group.
- Experiments two and three each contrasted the transport of PGE and sham vesicles, respectively, with the transport of day 13 embryos after the vesicles were placed into the uterine lumen with the embryo (seven subjects per group).
- In the second experiment, the PGE vesicles were less frequently transported from horn to body or from segment to segment compared to Day-13 embryos before inserting the vesicles. On the contrary, the third experiment found that sham vesicles were less frequently transported in the same conditions.
- In both experiment two and three, the transportation frequency of PGE vesicles and embryos or sham vesicles and embryos was indistinguishable, suggesting there’s no difference whether they exist together in the uterine lumen or not.
- In the fourth experiment, both PGE and sham vesicles were placed together in the uterine lumen of non-pregnant mares on Day 13. Similar to the previous results, no difference was found in vesicle transportation.
Conclusions
- Based on the results, the researchers concluded that PGE2 does not increase the uterine transport of simulated embryonic vesicles. These results contradict the original hypothesis.
- Furthermore, the results also imply that equine embryos do not stimulate uterine transport, contrasting another common belief.
- Therefore, the study suggests that both PGE2 and the presence of an embryo, whether real or simulated, have no significant impact on uterine transport in mares.
Cite This Article
APA
Vanderwall DK, Woods GL, Weber JA, Lichtenwalner AB.
(1993).
Uterine transport of prostaglandin E(2)-releasing simulated embryonic vesicles in mares.
Theriogenology, 40(1), 13-20.
https://doi.org/10.1016/0093-691x(93)90337-5 Publication
Researcher Affiliations
- Northwest Equine Reproduction Laboratory Department of Animal and Veterinary Science University of Idaho, Moscow, ID 83843 USA.
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