Validation of the EYEMATE-SC Suprachoroidal Pressure Transducer for Telemetric Measurement of Intraocular Pressure in Normal Ex Vivo Canine and Equine Globes-Preliminary Results.
Abstract: To determine the accuracy of the EYEMATE-SC suprachoroidal tracer for telemetric tonometry in canine and equine globes. Methods: The EYEMATE-SC sensor (7.8 mm × 3.8 mm × 1 mm) was implanted in the suprachoroidal space of four freshly enucleated normal canine and two normal equine eyes. The anterior chambers were cannulated and connected to a reservoir of Plasma-Lyte A and a manometer. Starting at a manometric IOP of 5 mmHg, the pressure was progressively increased to 80 mmHg by raising the reservoir. At each setpoint (5, 10, 15, 20, 25, 30, 35, 40, 50, 60, 70, and 80 mmHg), triplicate telemetric measurements were taken with the EYEMATE-SC using a portable reading device for telemetric pressure transmission via a radiofrequency band. These measurements were compared to manometric pressure by linear regression analysis. Results: A strong positive linear regression was observed between EYEMATE-SC and manometry IOPs in both canine and equine eyes (canine: R = 0.99; equine: R = 0.99). The EYEMATE-SC was unable to measure pressures > 70 mmHg in either species. Conclusions: Measuring canine and equine IOPs from the suprachoroidal space using the EYEMATE-SC provided accurate results over an extensive range of pressures in ex vivo globes. This telemetric sensor could assist with long-term, frequent tonometry by pet owners and clinicians following in vivo testing. Although the sensor could not detect pressures above 70 mmHg, this flaw was not considered clinically relevant.
© 2025 The Author(s). Veterinary Ophthalmology published by Wiley Periodicals LLC on behalf of American College of Veterinary Ophthalmologists.
Publication Date: 2025-08-29 PubMed ID: 40883863PubMed Central: PMC12488533DOI: 10.1111/vop.70071Google Scholar: Lookup
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- Journal Article
- Validation Study
Summary
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Overview
- This study evaluated the accuracy of the EYEMATE-SC suprachoroidal pressure transducer for measuring intraocular pressure (IOP) in ex vivo canine and equine eyes.
- The device showed strong correlation with manometric IOP values, suggesting potential use for telemetric monitoring of eye pressure in these animals.
Background
- Intraocular pressure (IOP) is an important parameter in diagnosing and monitoring ocular diseases such as glaucoma in animals and humans.
- Traditional tonometry methods require specialized equipment and trained personnel, limiting frequent and long-term monitoring.
- The EYEMATE-SC is a small, implantable telemetric sensor designed to continuously measure IOP wirelessly from the suprachoroidal space, a location within the eye.
- Validating such a device in common veterinary patients like dogs and horses can improve management of ocular diseases in these species.
Methods
- Subjects:
- Four freshly enucleated normal canine eyes
- Two freshly enucleated normal equine eyes
- Procedure:
- The EYEMATE-SC sensor (dimensions 7.8 mm × 3.8 mm × 1 mm) was surgically implanted into the suprachoroidal space of each eye.
- The anterior chambers of the eyes were cannulated and connected to a reservoir filled with Plasma-Lyte A fluid and a precise manometer to control and measure true IOP.
- IOP was gradually increased in steps from 5 mmHg up to 80 mmHg by raising the reservoir’s height.
- At each pressure setpoint (5, 10, 15, 20, 25, 30, 35, 40, 50, 60, 70, 80 mmHg), three telemetric measurements were taken with the EYEMATE-SC using a portable reading device that received pressure data wirelessly via radiofrequency transmission.
- Data Analysis:
- Telemetric IOP readings from the EYEMATE-SC were compared against manometric pressure values considered the gold standard.
- Linear regression analysis was conducted to assess the correlation and accuracy between the two measurement methods.
Results
- The EYEMATE-SC measurements showed a very strong positive linear correlation with manometric pressures in both canine and equine eyes (correlation coefficient R = 0.99 for both species), indicating high accuracy.
- The sensor functioned well over a wide range of IOPs but was unable to measure pressures above 70 mmHg in either species.
Conclusions and Implications
- The EYEMATE-SC proved capable of accurately measuring IOP across a broad physiological and supraphysiological pressure range in ex vivo canine and equine eyes.
- Its telemetric capability and implantation in the suprachoroidal space suggest feasibility for long-term, frequent IOP monitoring without repeated clinical visits or invasive measurements.
- This device could empower pet owners and veterinarians to monitor ocular health more closely, potentially improving management of eye diseases such as glaucoma in dogs and horses.
- While inability to measure pressures above 70 mmHg is a limitation, this upper limit is likely above clinically relevant thresholds for these species, minimizing practical impact.
- Future in vivo studies are needed to confirm safety, stability, and clinical usability before widespread adoption.
Cite This Article
APA
Buckman PN, Brinker BA, Kapeller LE, Komáromy AM.
(2025).
Validation of the EYEMATE-SC Suprachoroidal Pressure Transducer for Telemetric Measurement of Intraocular Pressure in Normal Ex Vivo Canine and Equine Globes-Preliminary Results.
Vet Ophthalmol, 28(5), 866-870.
https://doi.org/10.1111/vop.70071 Publication
Researcher Affiliations
- Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
- Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
- Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
- Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
MeSH Terms
- Animals
- Dogs / physiology
- Horses / physiology
- Intraocular Pressure / physiology
- Tonometry, Ocular / veterinary
- Tonometry, Ocular / instrumentation
- Tonometry, Ocular / methods
- Telemetry / veterinary
- Telemetry / instrumentation
- Telemetry / methods
- Transducers, Pressure / veterinary
Grant Funding
- R01 EY032478 / NEI NIH HHS
- R01-EY032478 / NIH HHS
Conflict of Interest Statement
A.M.K. received research funding from PolyActiva Pty. Ltd., AbbVie Inc., and W. L. Gore & Associates Inc. while the presented work was conducted. While A.M.K. also serves as Editor‐in‐Chief of Veterinary Ophthalmology, he was not involved in the review of this manuscript. All other authors declare no conflicts of interest.
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