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Home / Equine Research Bank / Arch Virol / Variation in cellular tropism between isolates of equine her...
Archives of virology1982; 74(1); 41-51; doi: 10.1007/BF01320781

Variation in cellular tropism between isolates of equine herpesvirus-1 in foals.

Abstract: Subtype-1 isolates of Equine herpesvirus-1 (EHV-1) from a quadriplegic horse and from an aborted foetus were compared with each other and with a subtype-2 respiratory isolate. All 3 isolates were detected in the epithelium and macrophages of the respiratory tract. Both the paresis and foetal subtype-1 isolates replicated in the epithelium of the ileum and this correlated with the recovery of virus from faeces in vivo. The paresis subtype-1 isolate also had a predelection for vascular endothelial cells, particularly in the nasal mucosa, but also in the lungs, central nervous system, adrenal and thyroid. In the 9 foals inoculated with the paresis isolate two developed hind limb dysfunction, four developed diarrhoea, and one of these 4 died with an intussusception. The differences between these isolates are discussed in relation to other herpesviruses.
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Publication Date: 1982-01-01 PubMed ID: 6297429DOI: 10.1007/BF01320781Google Scholar: Lookup
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article studies the differences in cellular tropism among three variants of Equine herpesvirus-1 (EHV-1) in young horses, unveiling unique traits related to their propagation and resulting symptoms.

Equine Herpesvirus-1 Variants

  • The research compared the cellular tropism (the cells a virus targets and can infect) of three EHV-1 isolates. These isolates were obtained from a horse suffering from quadriplegia (complete or partial paralysis of all four limbs), an aborted foetus, and a subtype-2 respiratory isolate.

Observations

  • All three isolates were observed to infect the epithelium (a cell layer covering the body surfaces) and macrophages (key components of the immune system) in the respiratory tract of the foals.
  • The isolates from the quadriplegic horse and the aborted foetus could also replicate within the epithelium of the ileum (a part of the small intestine), which correlated with the virus recovery from faeces in vivo (observed within the living organism).
  • The isolate from the quadriplegic horse further demonstrated a preference for infecting vascular endothelial cells, especially in the nasal mucosa, lungs, central nervous system, adrenal glands, and thyroid.

Clinical Manifestations

  • The study also evaluated the clinical manifestations (symptoms) in foals following inoculation (introduction of the virus) with the quadriplegic horse isolate.
  • Of the nine foals inoculated with this isolate, two developed hind limb dysfunction and four developed diarrhea. One of the foals with diarrhea died due to an intussusception (a condition where one segment of intestine invaginates within another, causing bowel obstruction).

Discussion on Differences

  • The study concludes with a discussion on the differences between these isolates in relation to other herpesviruses. The specifics of this discussion are not clarified in the abstract, but it would likely include comparisons to other herpesviruses and potential implications for understanding and managing EHV-1 infection in horses.

Cite This Article

APA
Patel JR, Edington N, Mumford JA. (1982). Variation in cellular tropism between isolates of equine herpesvirus-1 in foals. Arch Virol, 74(1), 41-51. https://doi.org/10.1007/BF01320781

Publication

Archives of virology
ISSN: 0304-8608
NlmUniqueID: 7506870
Country: Austria
Language: English
Volume: 74
Issue: 1
Pages: 41-51

Researcher Affiliations

Patel, J R
    Edington, N
      Mumford, J A

        MeSH Terms

        • Animals
        • Antigens, Viral
        • Cells, Cultured
        • Epithelium / microbiology
        • Herpesviridae / physiology
        • Herpesvirus 1, Equid / growth & development
        • Herpesvirus 1, Equid / isolation & purification
        • Herpesvirus 1, Equid / physiology
        • Horses / microbiology
        • Macrophages / microbiology
        • Paresis / etiology
        • Rabbits
        • Virus Replication

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