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Home / Equine Research Bank / Vet Res Commun / Variations of plasmatic concentrations of Insulin-like Growt...
Veterinary research communications2009; 33(7); 701-709; doi: 10.1007/s11259-009-9219-2

Variations of plasmatic concentrations of Insulin-like Growth Factor-I in post-pubescent horses affected with developmental osteochondral lesions.

Abstract: Developmental osteochondral lesions are often encountered in the equine population and are a major cause of lameness. Different growth factors that act systemically as well as locally regulate the growth of cartilage. Among them is Insulin-like Growth Factor I that has been demonstrated to promote chondrocyte growth and differentiation and that has been shown to influence cartilage repair. The aims of this study were to investigate differences in circulating plasma levels of Insulin-like Growth Factor-I in post-pubescent horses affected with developmental osteochondral lesions compared to unaffected ones. Significantly higher values of circulating Insulin-like Growth Factor-I levels were found in the affected group (n = 82) compared to controls (n = 86). This result may still reflect an earlier imbalance in IGF-I levels from horses with developmental osteochondral lesions considering the aetiopathological link which has been made between IGF-I and the occurrence of osteochondrosis. However, other studies have shown increased expression of IGF-I after cartilage damage. The higher levels found in this study could be due to a healing response of the cartilage to the damage caused by the osteochondral lesions.
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Publication Date: 2009-03-25 PubMed ID: 19319655DOI: 10.1007/s11259-009-9219-2Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about studying the differences in the levels of Insulin-like Growth Factor-I (IGF-I) in horses affected by developmental osteochondral lesions post-puberty compared to unaffected ones, and its potential role in cartilage repair.

Introduction to the Topic

  • The study focuses on a type of common injury known as developmental osteochondral lesions, typically observed in horses, which are a leading cause of lameness.
  • It is known that various growth factors, operating systematically and locally, influence the development and growth of cartilage.
  • Among these factors, one of significant interest to the researchers is the Insulin-like Growth Factor I (IGF-I).
  • Prior studies have highlighted the role of IGF-I in stimulating the growth and differentiation of chondrocytes – the cells responsible for cartilage production.

Objectives of the Study

  • The main aim of this study was to explore the differences in IGF-I levels in the plasma of post-puberty horses affected with developmental osteochondral lesions as opposed to those horses who remain unaffected.

Results and Findings

  • The researchers discovered significantly higher levels of circulating IGF-I in those horses affected by osteochondral lesions (82 in number), as compared to control horses who were not affected (86 in total).
  • This finding might be indicative of a prior imbalance in IGF-I in horses with developmental osteochondral lesions. This is due to the connection drawn in earlier research between the occurrence of osteochondrosis (a similar developmental condition in cartilage and bone) and IGF-I levels.

Implications

  • However, it’s also noted that other studies have shown increased IGF-I expression after any damage to the cartilage.
  • Therefore, the higher levels of IFG-I in horses with osteochondral lesions could be suggestive of a healing response by the cartilage to the injury caused by the lesions.

Cite This Article

APA
Verwilghen DR, Vanderheyden L, Franck T, Busoni V, Enzerink E, Gangl M, Lejeune JP, van Galen G, Grulke S, Serteyn D. (2009). Variations of plasmatic concentrations of Insulin-like Growth Factor-I in post-pubescent horses affected with developmental osteochondral lesions. Vet Res Commun, 33(7), 701-709. https://doi.org/10.1007/s11259-009-9219-2

Publication

Veterinary research communications
ISSN: 1573-7446
NlmUniqueID: 8100520
Country: Switzerland
Language: English
Volume: 33
Issue: 7
Pages: 701-709

Researcher Affiliations

Verwilghen, D R
  • Department of Clinical Sciences, Equine Clinic, Faculty of Veterinary Medicine of Liege, Sart-Tilman B41, 4000, Liege, Belgium. denis.verwilghen@ulg.ac.be
Vanderheyden, L
    Franck, T
      Busoni, V
        Enzerink, E
          Gangl, M
            Lejeune, J-P
              van Galen, G
                Grulke, S
                  Serteyn, D

                    MeSH Terms

                    • Aging / physiology
                    • Animals
                    • Cartilage / pathology
                    • Horse Diseases / blood
                    • Horse Diseases / epidemiology
                    • Horse Diseases / pathology
                    • Horses / classification
                    • Horses / growth & development
                    • Insulin-Like Growth Factor I / metabolism
                    • Joint Diseases / epidemiology
                    • Joint Diseases / veterinary
                    • Osteochondrosis / blood
                    • Osteochondrosis / epidemiology
                    • Osteochondrosis / pathology
                    • Osteochondrosis / veterinary
                    • Prevalence
                    • Species Specificity
                    • Wounds and Injuries / complications
                    • Wounds and Injuries / veterinary

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                    Citations

                    This article has been cited 3 times.
                    1. Baskerville CL, Chockalingham S, Harris PA, Bailey SR. The effect of insulin on equine lamellar basal epithelial cells mediated by the insulin-like growth factor-1 receptor. PeerJ 2018;6:e5945.
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                    2. Baskerville CL, Bamford NJ, Harris PA, Bailey SR. Comparison and validation of ELISA assays for plasma insulin-like growth factor-1 in the horse. Open Vet J 2017;7(1):75-80.
                      doi: 10.4314/ovj.v7i1.12pubmed: 28540255google scholar: lookup
                    3. Alemdar C, Yücel İ, Erbil B, Erdem H, Atiç R, Özkul E. Effect of insulin-like growth factor-1 and hyaluronic acid in experimentally produced osteochondral defects in rats. Indian J Orthop 2016 Jul-Aug;50(4):414-20.
                      doi: 10.4103/0019-5413.185607pubmed: 27512224google scholar: lookup
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