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Veterinary research communications1994; 18(6); 447-456; doi: 10.1007/BF01839422

Vasomotor effects of histamine on bovine and equine basilar arteries in vitro.

Abstract: The vasomotor effects of histamine on isolated bovine and equine basilar arteries were examined. Histamine induced contractions in both these preparations. The maximal response to and pEC50 value for histamine of the equine artery were larger than those of bovine tissue. Similar results were obtained with endothelium-denuded basilar arteries. Diphenhydramine (H1-receptor antagonist) inhibited histamine-induced contractions of the basilar arteries from both species in a concentration-dependent manner and its pA2 values (with 95% confidence limits) were 7.61 (7.39-7.83) and 8.15 (8.01-8.29) for the bovine and equine preparations, respectively. Cimetidine (H2-receptor antagonist) slightly potentiated histamine-induced contractions of bovine, but not equine, basilar arteries. 2-Thiazolylethylamine (H1-receptor agonist) induced contractions in both preparations, whereas impromidine (H2-receptor agonist) induced weak relaxation of the bovine, but not the equine, tissue. These findings indicate that bovine basilar arterial smooth muscle cells possess H1- and H2-receptors. Stimulation of the former results in contraction, whereas stimulation of the latter results in weak relaxation. Equine basilar arterial smooth muscle cells possess H1-receptors, stimulation of which results in contraction.
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Publication Date: 1994-01-01 PubMed ID: 7701783DOI: 10.1007/BF01839422Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates the impact of histamine on isolated basilar arteries (located at the base of the brain) from cows and horses. It found that histamine can cause these arteries to contract, with varying effects across species. Different substances which impact histamine receptors demonstrated varying levels of artery contraction or relaxation.

Study Design and Experimentation

  • The researchers studied the vasomotor effects – the changes in diameter of the blood vessels – of histamine on isolated basilar arteries from bovines (cows) and equine (horses).
  • The team subjected these arteries to histamine and observed the contractions in the arteries. Two key measurement values were the maximum response to the histamine (the size of the contraction) and the pEC50 value (the concentration of histamine at which the response is halfway between the maximal and basal responses).
  • This study also explored histamine’s effect on endothelium-denuded basilar arteries – arteries stripped of their innermost lining – of both bovine and equine samples.

Findings

  • The application of histamine resulted in contractions in the sample arteries for both species. Notably, the maximum response and sensitivity (pEC50 value) of equine arteries were both larger than those of bovine arteries.
  • Scientists further used the H1-receptor antagonist diphenhydramine to inhibit histamine-induced contractions, which was effective in a concentration-dependent manner. The pA2 values reflect the concentration of antagonist needed to reduce the maximal response to histamine. Bovine and equine preparations had different pA2 values, showing different sensitivities to this antagonist.
  • In addition, the researchers detected slight potentiation – increased contraction response – in bovine basilar arteries but not equine arteries when using the H2-receptor antagonist cimetidine.
  • Experiments involving 2-Thiazolylethylamine (H1-receptor agonist) led to contractions in both types of arteries, while impromidine (H2-receptor agonist) caused weak relaxation in bovine, but not in equine arteries.

Conclusions and Implications

  • The findings suggest that bovine basilar arterial smooth muscle cells possess both H1- and H2-receptors, which are linked to contraction and weak relaxation respectively when stimulated.
  • On the other hand, equine basilar arterial smooth muscle cells appear to possess H1-receptors, with their stimulation resulting in contraction. The absence of relaxation response to the H2-receptor agonist in equine arteries indicates that these cells may lack H2-receptors.
  • In essence, histamine can affect the diameter of bovine and equine basilar arteries by causing them to contract or relax, but the extent and direction of this response can differ based on the species and type of histamine receptor involved.

Cite This Article

APA
Miyamoto A, Nishio A. (1994). Vasomotor effects of histamine on bovine and equine basilar arteries in vitro. Vet Res Commun, 18(6), 447-456. https://doi.org/10.1007/BF01839422

Publication

Veterinary research communications
ISSN: 0165-7380
NlmUniqueID: 8100520
Country: Switzerland
Language: English
Volume: 18
Issue: 6
Pages: 447-456

Researcher Affiliations

Miyamoto, A
  • Department of Veterinary Pharmacology, Faculty of Agriculture, Kagoshima University, Japan.
Nishio, A

    MeSH Terms

    • Animals
    • Basilar Artery / drug effects
    • Basilar Artery / physiology
    • Cattle
    • Histamine / pharmacology
    • Histamine Agonists / pharmacology
    • Histamine Antagonists / pharmacology
    • Horses
    • Muscle Contraction / drug effects
    • Muscle, Smooth, Vascular / drug effects
    • Muscle, Smooth, Vascular / physiology

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    Citations

    This article has been cited 5 times.
    1. Wu S, Ootawa T, Sekio R, Smith H, Islam MZ, Nguyen HTT, Uno Y, Shiraishi M, Miyamoto A. Reduced Nitric Oxide Synthase Involvement in Aigamo Duck Basilar Arterial Relaxation. Animals (Basel) 2023 Aug 28;13(17).
      doi: 10.3390/ani13172740pubmed: 37685004google scholar: lookup
    2. Islam MZ, Sawatari Y, Kojima S, Kiyama Y, Nakamura M, Sasaki K, Otsuka M, Obi T, Shiraishi M, Miyamoto A. Vasomotor effects of 5-hydroxytryptamine, histamine, angiotensin II, acetylcholine, noradrenaline, and bradykinin on the cerebral artery of bottlenose dolphin (Tursiops truncatus). J Vet Med Sci 2020 Oct 20;82(10):1456-1463.
      doi: 10.1292/jvms.20-0351pubmed: 32814751google scholar: lookup
    3. Islam MZ, Watanabe Y, Nguyen HT, Yamazaki-Himeno E, Obi T, Shiraishi M, Miyamoto A. Vasomotor effects of acetylcholine, bradykinin, noradrenaline, 5-hydroxytryptamine, histamine and angiotensin II on the mouse basilar artery. J Vet Med Sci 2014 Oct;76(10):1339-45.
      doi: 10.1292/jvms.14-0223pubmed: 24942113google scholar: lookup
    4. Miyamoto A, Wada R, Inoue A, Ishiguro S, Liao JK, Nishio A. Role of angiotensin II receptor subtypes in porcine basilar artery: functional, radioligand binding, and cell culture studies. Life Sci 2006 Jan 25;78(9):943-9.
      doi: 10.1016/j.lfs.2005.06.044pubmed: 16223512google scholar: lookup
    5. Islam MZ, Wu S, Ootawa T, Smith H, Nguyen HTT, Harada E, Miyamoto A. Characteristics of Cerebrovascular Response to Intrinsic Vasoactive Substances in Sika Deer (Cervus nippon yesoensis) and the Possible Effects of Gravity on Adrenergic Responses. Animals (Basel) 2024 Dec 4;14(23).
      doi: 10.3390/ani14233500pubmed: 39682465google scholar: lookup
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