ALTEX.
Publisher:
Spektrum Akademischer Verlag,
Frequency: Quarterly
Country: Germany
Language: ger
Author(s):
Mitteleuropäische Gesellschaft für Alternativmethoden zu Tierversuchen., Johns Hopkins Center for Alternatives to Animal Testing., European Society for Alternatives to Animal Testing., Society ALTEX Edition.
Start Year:1994 -
ISSN:
1868-596X (Print)
1868-8551 (Electronic)
1868-596X (Linking)
1868-8551 (Electronic)
1868-596X (Linking)
Impact Factor
5.6
2022
| NLM ID: | 100953980 |
| (OCoLC): | 45463726 |
| LCCN: | 00-243539 |
| Classification: | W1 AL989k |
Ex vivo model unravelling cell distribution effect in hydrogels for cartilage repair. The implantation of chondrocyte-laden hydrogels is a promising cartilage repair strategy. Chondrocytes can be spatially positioned in hydrogels and thus in defects, while current clinical cell therapies introduce chondrocytes in the defect depth. The main aim of this study was to evaluate the effect of spatial chondrocyte distribution on the reparative process. To reduce animal experiments, an ex vivo osteochondral plug model was used and evaluated. The role of the delivered and endogenous cells in the repair process was investigated. Full thickness cartilage defects were created in equine ost...
Training of upper respiratory endoscopy in the horse using preserved head and neck. Endoscopy of the upper respiratory tract (URT) is one of the minimally invasive techniques used for diagnosis and treatment of diseases in horses. Training in the use of an endoscope follows an apprenticeship approach, with extensive practice needed to help achieve effective skills acquisition. The use of live animals for training presents the risk of injury to both the animal and the trainee. The increased number of students and practitioners, a shortage of facilities, and limited time available from expert clinicians add more challenges to the training process. In this work, we focused on th...
Replacement of the in vivo neutralisation test for efficacy demonstration of tetanus vaccines ad us. vet. The bacterium Clostridium (C.) tetani is an ubiquitous pathogen. This anaerobic, gram-positive bacterium can form spores and can be found in the whole environment. It enters the body via injuries of the skin and wounds where it releases the neurotoxin "tetanospasmin" (= tetanus toxin). The animals most susceptible to tetanus infection are horses and sheep. Only active immunisation by tetanus vaccine provides effective protection against tetanus intoxication. The marketing authorisation requirements stipulate that efficacy of tetanus vaccines ad us. vet. must be demonstrated in all target anima...