The American journal of the medical sciences.
Publisher:
J. B. Lippincott. New York : Elsevier (2016)
Frequency: Monthly, 1984-
Country: United States
Language: English
Author(s):
Southern Society for Clinical Investigation (U.S.)
Start Year:1827 -
ISSN:
0002-9629 (Print)
1538-2990 (Electronic)
0002-9629 (Linking)
1538-2990 (Electronic)
0002-9629 (Linking)
Impact Factor
3.1
2022
| NLM ID: | 0370506 |
| (DNLM): | A24405000(s) |
| (OCoLC): | 01480197 |
| Coden: | AJMSA9 |
| LCCN: | 50004912 |
| Classification: | W1 AM524 |
Treatment of aplastic anemia with an investigational antilymphocyte serum prepared in rabbits. The authors evaluated antilymphocyte serum prepared in rabbits (ALS-R) as an alternative to antilymphocyte serum prepared in horses (ALG-H) in the therapy of aplastic anemia. Between 1980 and 1993, 57 evaluable patients received ALS-R and prednisone +/- cyclosporine +/- androgens. Standard response criteria were used and patients were evaluated at 3 months from the start of therapy. Median age was 43 years. Disease was present for up to 2 months in 24 patients, 2-5 months in 14 patients, and 6 months or more in 19 patients. Disease was severe in 30 patients and moderate in 27. Responses occurr...