Anesthesiology.
Publisher:
American Society of Anesthesiologists. Philadelphia Pa : Lippincott Williams & Wilkins
Frequency: Monthly
Country: United States
Language: English
Author(s):
American Society of Anesthesiologists., American Society of Anesthetists.
Start Year:1940 -
Identifiers
| ISSN: | 0003-3022 (Print) 1528-1175 (Electronic) 0003-3022 (Linking) |
| NLM ID: | 1300217 |
| (DNLM): | A30435000(s) |
| (OCoLC): | 01481133 |
| Coden: | ANESAV |
| LCCN: | sn 78004565 |
| Classification: | W1 AN22H |
Solubility of haloether anesthetics in human and animal blood. Anesthetic blood solubility predicts pharmacokinetics for inhaled agents and is essential for determination of blood anesthetic concentrations from end-tidal gas concentrations using Henry's Law. Though used to model anesthetic effects in humans, there are limited interspecies solubility comparisons that include modern haloethers. This study aimed to measure hematocrit-adjusted blood:gas anesthetic partition coefficients (λ B:G) for desflurane, sevoflurane, isoflurane, and methoxyflurane in humans and animals. Methods: Whole blood was collected from 20 rats, 8 horses, and 4 each of cats, catt...