Archives internationales de pharmacodynamie et de thérapie.
Discontinued
Publisher:
Heymans Institute of Pharmacology.
Frequency: Bimonthly, -1996
Country: Belgium
Language: English
Author(s):
Heymans Institute of Pharmacology.
Start Year:1899 - 1996
Identifiers
| ISSN: | 0003-9780 (Print) 0003-9780 (Linking) |
| NLM ID: | 0405353 |
| (DNLM): | A61290000(s) |
| (OCoLC): | 05806034 |
| Coden: | AIPTAK |
| Classification: | W1 AR393R |
Pharmacokinetics of xylazine in ponies: influence of yohimbine. Twenty healthy ponies were given i.v. 1.1 mg/kg of xylazine from 2 manufacturers and the pharmacokinetic parameters calculated from the disposition curves. The disposition curves for the 2 commercial preparations were not different. Yohimbine, an antagonist of the pharmacologic effects produced by xylazine, did not alter the disposition of xylazine in the plasma. A single i.v. bolus of xylazine was completely described in 17 of 20 animals by the biexponential equation: Cp = 1.30e(-0.3955t) + 0.58e(-0.033t) where Cp represents the concentration of xylazine in the plasma at time t (min). The t1/...