Biochemistry and biophysics reports.
Publisher:
Elsevier B.V.,
Country: Netherlands
Language: English
Start Year:2015 -
ISSN:
2405-5808 (Electronic)
2405-5808 (Linking)
2405-5808 (Linking)
Impact Factor
2.7
2022
| NLM ID: | 101660999 |
| (OCoLC): | 926100761 |
| LCCN: | 2015243429 |
| Classification: | W1 |
Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory ‘multi-omics’ study to identify composite biomarkers. Osteoarthritis causes progressive joint deterioration, severe morbidity, and reduced mobility in both humans and horses. Currently, osteoarthritis is diagnosed at late stages through clinical examination and radiographic imaging, hence it is challenging to address and provide timely therapeutic interventions to slow disease progression or ameliorate symptoms. Extracellular vesicles are cell-derived vesicles that play a key role in cell-to-cell communication and are potential sources for specific composite biomarker panel discovery. We here used a multi-omics strategy combining proteomics and p...
Conditionally immortalised equine skeletal muscle cell lines for in vitro analysis. Thoroughbred racehorse performance is largely influenced by a major quantitative trait locus at the () gene which determines aptitude for certain race distances due to a promoter region insertion mutation influencing functional phenotypes in skeletal muscle. To develop an system for functional experiments we established three novel equine skeletal muscle cell lines reflecting the variation in phenotype associated with genotype (CC/II, CT/IN and TT/NN for SNP g.66493737C > T/SINE insertion 227 bp polymorphism). Primary equine skeletal muscle myoblasts, isolated from Thoroughbred horse , we...