Biochemical pharmacology.
Periodical
Biochemistry
Pharmacology
Chemistry
Pharmaceutical
Publisher:
Paragamon Press.. Oxford : Elsevier Science
Frequency: Monthly, 2018-
Country: England
Language: English
Start Year:1958 -
ISSN:
0006-2952 (Print)
1873-2968 (Electronic)
0006-2952 (Linking)
1873-2968 (Electronic)
0006-2952 (Linking)
Impact Factor
5.8
2022
| NLM ID: | 0101032 |
| (DNLM): | B14940000(s) |
| (OCoLC): | 01536391 |
| Coden: | BCPCA6 |
| LCCN: | 58004837 |
| Classification: | W1 BI622 |
The blood and saliva clearances of phenobarbitone and pentobarbitone in the horse.
Biochemical pharmacology
February 1, 1968
Volume 17, Issue 2 203-210 doi: 10.1016/0006-2952(68)90324-9
Alexander F, Nicholson JD.No abstract available The urinary excretion of phenobarbitone and pentobarbitone in the horse.
Biochemical pharmacology
January 1, 1968
Volume 17, Issue 1 1-8 doi: 10.1016/0006-2952(68)90150-0
Nicholson JD.No abstract available The salivary secretion and clearance in the horse of chloral hydrate and its metabolites.
Biochemical pharmacology
July 7, 1967
Volume 16, Issue 7 1305-1311 doi: 10.1016/0006-2952(67)90161-x
Alexander F, Horner MW, Moss MS.No abstract available The reaction of organophosphorus compounds with hydrolytic enzymes. The inhibition of horse liver aliesterase.
Biochemical pharmacology
December 1, 1965
Volume 14, Issue 12 1727-1738 doi: 10.1016/0006-2952(65)90262-5
Ooms AJ, Breebaart-Hansen JC.No abstract available Proteolysis of salmine by horse urinary kallikrein.
Biochemical pharmacology
November 1, 1965
Volume 14, Issue 11 1665-1671 doi: 10.1016/0006-2952(65)90021-3
Brandi CM, Mendes J, Paiva AC, Prado ES.No abstract available Digitoxin metabolism by rat liver microsomes.
Biochemical pharmacology
September 1, 1975
Volume 24, Issue 17 1639-1641 doi: 10.1016/0006-291x(75)90200-4
Schmoldt A, Benthe HF, Haberland G, Jallon JM, Risler Y, Iwatsubo M, Karuzina II, Bachmanova GI, Kuznetsova GP, Izotov MV, Archakov AI, Kröger H....It has been found that NADPH-dependent hydroxylation of dimethylaniline, aniline, p- and o-nitroanisol and lipid peroxidation is inhibited by the tyrosine-copper (II) complex (low molecular weight analog of superoxide dismutase), which is indicative of a possibility of superoxide radicals formation in these reactions. The inhibition of the above-mentioned reactions with Tyr2-Cu2+ is less pronounced or absent, if cumole hydroperoxide is used as cosubstrate instead of NADPH. Differences in the Tyr2-Cu2+ complex effects on the cumule hydroperoxide-dependent xenobiotics hydroxylation and lipid per... Read More
90
Digitoxin metabolism by rat liver microsomes.
Biochemical pharmacology
September 1, 1975
Volume 24, Issue 17 1639-1641 doi: 10.1016/b978-0-12-152810-2.50012-7
Schmoldt A, Benthe HF, Haberland G, Scott WA, Mahoney E, BOSE SK.No abstract available Read More
66
Digitoxin metabolism by rat liver microsomes.
Biochemical pharmacology
September 1, 1975
Volume 24, Issue 17 1639-1641
Schmoldt A, Benthe HF, Haberland G.No abstract available Read More
66
Digitoxin metabolism by rat liver microsomes.
Biochemical pharmacology
September 1, 1975
Volume 24, Issue 17 1639-1641 doi: 10.1016/b978-0-12-152810-2.50012-7
Schmoldt A, Benthe HF, Haberland G, Scott WA, Mahoney E, FISCHER H, FELDT K.No abstract available Read More
66
Digitoxin metabolism by rat liver microsomes.
Biochemical pharmacology
September 1, 1975
Volume 24, Issue 17 1639-1641 doi: 10.1016/0006-291x(75)90337-x
Schmoldt A, Benthe HF, Haberland G, Tarentino AL, Maley F, Berkmen YM, Lande A, Ti-sheng C, Teh-chao W.The chest roentgenographic findings in Takayasu's arteritis include widening of the ascending aorta, contour irregularities of the descending aorta, arotic calcifications, pulmonary arterial changes, rib notching, and hilar lymphadenopathy. The single most important diagnostic sign is a segmental calcification outlining a localized or diffuse narrowing of the aorta. The other signs may be suspicious or suggestive, but the diagnostic accuracy increases when several findings are present simultaneously. Read More
66
Digitoxin metabolism by rat liver microsomes.
Biochemical pharmacology
September 1, 1975
Volume 24, Issue 17 1639-1641 doi: 10.1016/0006-291x(75)90337-x
Schmoldt A, Benthe HF, Haberland G, Tarentino AL, Maley F, Berkmen YM, Lande A, Fine JM, Lambin P, Derycke C, North ML, Chataing B, Goudemand M.The chest roentgenographic findings in Takayasu's arteritis include widening of the ascending aorta, contour irregularities of the descending aorta, arotic calcifications, pulmonary arterial changes, rib notching, and hilar lymphadenopathy. The single most important diagnostic sign is a segmental calcification outlining a localized or diffuse narrowing of the aorta. The other signs may be suspicious or suggestive, but the diagnostic accuracy increases when several findings are present simultaneously. A routine screening of monoclonal gammopathies (M.G.) was performed in the serum from 36, 015 ... Read More
66
Digitoxin metabolism by rat liver microsomes.
Biochemical pharmacology
September 1, 1975
Volume 24, Issue 17 1639-1641 doi: 10.1016/0005-7967(77)90095-x
Schmoldt A, Benthe HF, Haberland G, Sinelnikova EM, Dvoretskova TV, Kagan ZS, Marshall WL, Stoian M, Andrews WR.It has been shown that for the reaction catalyzed by "biodegradative" L-threonine dehydratase from E. coli strains K-12 and 980 in 0.5 M phosphate-carbonate buffer, pH 8.4 and pH 9.5, the plots of initial reaction rate (v) versus the initial substrate concentration ([S]0 are characterized by several inflection points, i. e. an intermediate plateau. The plot of v versus the allosteric activator (AMP) concentration have very complicated shapes: there are several inflection points, and also the maximum at L-threonine concentration equal to 3-10(2) and 5-10(-2) M. High AMP concentrations inhibit t... Read More
66
Thymidine concentrations in serum and urine of different animal species and man.
Biochemical pharmacology
November 15, 1977
Volume 26, Issue 22 2175-2179 doi: 10.1016/0006-2952(77)90271-4
Nottebrock H, Then R.No abstract available Read More
40
Pharmacological and biochemical characterization of the beta-adrenergic signal transduction pathway in different segments of the respiratory tract.
Biochemical pharmacology
September 10, 2003
Volume 66, Issue 6 1067-1081 doi: 10.1016/s0006-2952(03)00460-x
Abraham G, Kottke C, Dhein S, Ungemach FR.Although in the respiratory system there is great therapeutic interest in manipulating and understanding the beta-adrenoceptor-G-protein-adenylate cyclase (AC) signal transduction pathway, little is known on segmental differences among lung, bronchus, and trachea with regard to the receptor concentration and interaction to G-proteins and coupling to AC. In this study, patterns of distribution and absolute quantities of beta-adrenoceptor subtypes beta(1) and beta(2) were determined in membranes of equine lung parenchyma, bronchial and tracheal epithelium with the underlying smooth muscle by sat... Read More
11
Characterization of the in vitro CYP450 mediated metabolism of the polymorphic CYP2D6 probe drug codeine in horses.
Biochemical pharmacology
July 8, 2019
Volume 168 184-192 doi: 10.1016/j.bcp.2019.07.005
Knych HK, Baden RW, Gretler SR, McKemie DS.Despite their widespread popularity as sport and companion animals and published and anecdotal reports of vast difference in drug disposition and pharmacokinetics between individuals, studies describing equine drug metabolism are limited. It has been theorized that similar to humans, members of the CYP2D family in horses may be polymorphic in nature leading to differences in metabolism of substrates. This study aims to build on the limited current knowledge regarding P450 mediated metabolism in horses by describing the metabolism of the polymorphic CYP2D6 probe drug codeine in vitro. Codeine, ... Read More
10
Adenosinergic signalling in chondrogenesis and cartilage homeostasis: Friend or foe?
Biochemical pharmacology
December 26, 2019
Volume 174 113784 doi: 10.1016/j.bcp.2019.113784
Pinto-Cardoso R, Pereira-Costa F, Pedro Faria J, Bandarrinha P, Bessa-Andrês C, Correia-de-Sá P, Bernardo Noronha-Matos J.Chondrocytes and their mesenchymal cell progenitors secrete a variety of bioactive molecules, including adenine nucleotides and nucleosides, but these molecules are not usually highlighted in review papers about the secretome of these cells. Ageing and inflammatory insults compromise chondrocytes ability to keep ATP/adenosine synthesis, release and turnover. Cartilage homeostasis depends on extracellular adenosine levels, which acting via four P1 purinoceptor subtypes modulates the release of pro-inflammatory mediators, including NO, PGE and several cytokines. Native articular cartilage is cha... Some properties of soluble proteins from chromaffin granules of different species.
Biochemical pharmacology
August 1, 1968
Volume 17, Issue 8 1553-1556 doi: 10.1016/0006-2952(68)90214-1
Strieder N, Ziegler E, Winkler H, Smith AD.No abstract available A comparison of drug binding sites on mammalian albumins.
Biochemical pharmacology
September 1, 1992
Volume 44, Issue 5 873-879 doi: 10.1016/0006-2952(92)90118-3
Panjehshahin MR, Yates MS, Bowmer CJ.The fluorescent probes warfarin and dansylsarcosine are known to selectively interact with binding sites I and II, respectively, on human albumin. This paper investigates whether similar binding sites exist on bovine, dog, horse, sheep and rat albumins. Binding sites on albumins were studied by: (1) displacement of warfarin and dansylsarcosine by site I (phenylbutazone) and site II (diazepam) selective ligands; (2) the effects of non-esterified fatty acids (carbon chain lengths: C5-C20) and changes in pH (6-9) on the fluorescence of warfarin and dansylsarcosine; and (3) the ability of site sel... Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation.
Biochemical pharmacology
March 16, 2000
Volume 59, Issue 7 773-781 doi: 10.1016/s0006-2952(99)00389-5
Wierdl M, Morton CL, Danks MK, Potter PM.Butyrylcholinesterases (BuChEs; acylcholine acylhydrolase; EC 3.1.1.8) have been demonstrated to convert the anticancer agent CPT-11 (irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) into its active metabolite SN-38 (7-ethyl-10-hydroxycamptothecin). In addition, significant differences in the extent of drug metabolism have been observed with BuChEs derived from different species. In an attempt to understand these differences, we have isolated the cDNA encoding a horse BuChE. Based upon the NH2-terminal amino acid sequence of a purified horse BuChE, we designed deg... In vitro febantel transformation by sheep and cattle ruminal fluids and metabolism by hepatic subcellular fractions from different animal species.
Biochemical pharmacology
October 1, 1987
Volume 36, Issue 19 3107-3114 doi: 10.1016/0006-2952(87)90619-8
Beretta C, Fadini L, Stracciari JM, Montesissa C.Febantel and one of its main metabolites, febantel sulphoxide, are chemically modified to only a slight extent when incubated in vitro with sheep and cattle ruminal fluids; other major metabolites, fenbendazole and oxfendazole, are respectively, oxidized to oxfendazole and reduced to fenbendazole. Febantel is negligibly metabolized by hepatic cytosol fractions but microsome preparations effect more extensive metabolic transformations. Important differences in this respect were found between microsome preparations from rat, horse, pig, cattle, sheep, chicken and trout livers. Kallidin (lysylbradykinin), the kinin formed from horse plasma by horse urinary kallikrein.
Biochemical pharmacology
August 1, 1971
Volume 20, Issue 8 2009-2015 doi: 10.1016/0006-2952(71)90400-x
Prado ES, Webster ME, Prado JL.Horse urinary kallikrein when incubated with horse plasma formed kallidin (lysylbradykinin) from the kininogens in the plasma. Horse plasma, like human plasma, was found to contain an aminopeptidase capable of converting kallidin to bradykinin. No evidence, however, could be found that the plasma contained an aminopeptidase capable of converting Met-Lys-bradykinin to kallidin, thus eliminating the possibility that the kallikrein had released Met-Lys-bradykinin which was converted to kallidin during the 1–5 min incubations. The method used for identification of the kinins is rapid, gives a go... Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver.
Biochemical pharmacology
July 23, 2008
Volume 76, Issue 7 904-911 doi: 10.1016/j.bcp.2008.07.016
DiMaio Knych HK, Stanley SD.Members of the CYP2D family constitute only about 2-4% of total hepatic CYP450s, however, they are responsible for the metabolism of 20-25% of commonly prescribed therapeutic compounds. CYP2D enzymes have been identified in a number of different species. However, vast differences in the metabolic activity of these enzymes have been well documented. In the horse, the presence of a member of the CYP2D family has been suggested from studies with equine liver microsomes, however its presence has not been definitively proven. In this study a cDNA encoding a novel CYP2D enzyme (CYP2D50) was cloned f... Comparative warfarin binding to albumin from various species.
Biochemical pharmacology
December 15, 1977
Volume 26, Issue 24 2445-2447 doi: 10.1016/0006-2952(77)90455-5
Seller EM, Lang-Sellers ML, Koch-Weser J.No abstract available Proteolysis of salmine by horse urinary kallikrein.
Biochemical pharmacology
November 1, 1965
Volume 14, Issue 11 1665-1671 doi: 10.1016/0006-2952(65)90021-3
Brandi CM, Mendes J, Paiva AC, Prado ES.No abstract available 3-Hydroxy- and 3-keto-3-phenylpropionic acids: novel metabolites of benzoic acid in horse urine.
Biochemical pharmacology
October 15, 1982
Volume 31, Issue 20 3225-3230 doi: 10.1016/0006-2952(82)90554-8
Marsh MV, Caldwell J, Hutt AJ, Smith RL, Horner MW, Houghton E, Moss MS.The metabolism of benzoic acid has been examined in the horse, using 14C- and deuterium-labelled compounds. Chromatographic analysis of the urine showed the presence of hippuric acid, benzoyl glucuronide and benzoic acid and a discrete band which accounted for 2% of the dose administered. This material was isolated by solvent extraction and HPLC and, following treatment with diazomethane, examined by GC/MS. The major component of this fraction was 3-hydroxy-3-phenylpropionic acid methyl ester, which was accompanied by very much smaller amounts of cinnamic acid methyl ester and acetophenone. Th... The blood and saliva clearances of phenobarbitone and pentobarbitone in the horse.
Biochemical pharmacology
February 1, 1968
Volume 17, Issue 2 203-210 doi: 10.1016/0006-2952(68)90324-9
Alexander F, Nicholson JD.No abstract available The urinary excretion of phenobarbitone and pentobarbitone in the horse.
Biochemical pharmacology
January 1, 1968
Volume 17, Issue 1 1-8 doi: 10.1016/0006-2952(68)90150-0
Nicholson JD.No abstract available The salivary secretion and clearance in the horse of chloral hydrate and its metabolites.
Biochemical pharmacology
July 7, 1967
Volume 16, Issue 7 1305-1311 doi: 10.1016/0006-2952(67)90161-x
Alexander F, Horner MW, Moss MS.No abstract available Kinins released from horse heat-acid-denaturated plasma by plasmin, plasma kallikrein, trypsin and Bothrops kininogenase.
Biochemical pharmacology
June 1, 1970
Volume 19, Issue 6 2091-2096 doi: 10.1016/0006-2952(70)90307-2
Gapanhuk E, Henriques OB.No abstract available Comparative action of various kininogenases on crude horse plasma substrates.
Biochemical pharmacology
June 1, 1970
Volume 19, Issue 6 2083-2090 doi: 10.1016/0006-2952(70)90306-0
Budnitskaya P, Gapanhuk E, Henriques OB.The kininogenase activity of trypsin, plasmin, plasma kallikrein and heated Bothrops venom was compared, using fresh, heated and heat-acid-denatured horse plasma as source of kininogen. The venom kininogenase was found to have the highest activity on fresh horse plasma, followed by plasmin and trypsin which were equally active, and plasma kallikrein which was half as active as plasmin on these substrates. Plasmin and trypsin released more kinin from heat-treated than from fresh plasma whereas kallikrein released half as much as it liberates from fresh plasma. On heat-aciddenatured plasma equal... Identification and kinetics of microsomal and recombinant equine liver cytochrome P450 enzymes responsible for in vitro metabolism of omeprazole.
Biochemical pharmacology
June 5, 2023
Volume 214 115635 doi: 10.1016/j.bcp.2023.115635
Ferlini Agne G, Somogyi AA, Sykes B, Knych H, Franklin S.In humans, omeprazole is metabolised by cytochrome P450 (CYP450) CYP2C19 and CYP3A4 with differences in CYP2C19 genotypes leading to variable response to therapy. Despite a wide use of omeprazole in horses with evidence of variable therapeutic efficiency, information regarding enzymatic metabolism is not currently available. This study aims to describe the in vitro kinetics of omeprazole metabolism and determine which enzyme(s) are responsible for omeprazole metabolism in horses. Omeprazole (0-800 uM) was incubated with liver microsomes and a panel of equine recombinant CYP450s (eq-rCYP). Meta... Cytotaxin-induced cAMP peak in granulocytes: its relationship to crawling movements, chemokinesis and chemotaxis.
Biochemical pharmacology
April 15, 1982
Volume 31, Issue 8 1573-1577 doi: 10.1016/0006-2952(82)90382-3
Naef A, Damerau B, Keller HU.The relationship between the short transient intracellular increase in cAMP levels on the one hand and chemotaxis or crawling movements on the other hand was investigated using human and equine granulocytes. C5ades arg, f-met-leu-phe, human serum albumin and immunoglobulin were used as stimulating agents. There was no strict correlation between the induction of crawling movements or of chemokinesis in general and the generation of the cAMP peak. But there was so far a strict parallelism between the occurrence of the chemotactic response and the cAMP peak. However, the magnitude of the peak was... Inhibition of the pseudocholinesterase in horse serum by some choline analogues.
Biochemical pharmacology
August 1, 1968
Volume 17, Issue 8 1595-1599 doi: 10.1016/0006-2952(68)90220-7
Beckett AH, Vaughan CL, Mitchard M.No abstract available Hepatic drug metabolism in vitro in the horse.
Biochemical pharmacology
November 1, 1971
Volume 20, Issue 11 3219-3221 doi: 10.1016/0006-2952(71)90128-6
Yeary RA, Gerken D.No abstract available Stability studies on crude and purified horse serum cholinesterase.
Biochemical pharmacology
July 1, 1969
Volume 18, Issue 7 1701-1705 doi: 10.1016/0006-2952(69)90159-2
Beckett AH, Vaughan CL, Mitchard M.No abstract available